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All Journal Majalah Kedokteran Gigi Indonesia Conservative Dentistry Journal
Hartanli, Audrey Luisa
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Dentistry

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Anti-microbial efficacy of garlic (Allium Sativum L.) extract as a root canal irrigant in endodontic treatment Cahyani, Febriastuti; Farizaldi, Reisya Irfanny; Syafaati, Lailatul Maghfiroh; Hartanli, Audrey Luisa; Aryandhita, Amanda Paramitha Putri
Conservative Dentistry Journal Vol. 13 No. 2 (2023): July-December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cdj.v13i2.2023.91-95

Abstract

Background: Herbal medications are an effective alternative in dental endodontic treatment due to their antimicrobial, anti-inflammatory, and biocompatibility properties and thus they are more biocompatible and less cytotoxic. The antibacterial, antifungal, and antiviral properties of garlic (Allium sativum L.) support broad-spectrum activity against gram-positive and gram-negative organisms and effectiveness against multidrug-resistant organisms that are essential as endodontic materials. Purpose: The purpose of this literature review is to analyze how the antimicrobial efficacy of garlic (Allium sativum L.) extract can be used as a root canal irrigant in endodontic treatment. Review: The development of pulp and periapical disease involves high-intensity bacterial activity that proliferates and produces toxic side products such as organic acids. When crushed or minced, garlic releases allicin compounds through the enzymatic action of alliinase (cysteine sulfoxide lyase) on alliin. Allicin, organosulfur compounds, and antioxidant compounds in garlic extract can exert antimicrobial role by inhibiting the synthesis of pathogenic microorganisms, fighting the resulting infection, and working synergistically with other antimicrobial agents to increase the effectiveness of treatment against antibiotic- resistant bacterial infections. In comparison to other antimicrobial agents, a number of studies have shown that there is no significant difference between garlic extract and sodium hypochlorite (NaOCl) in exerting bactericidal effects against pathogenic bacteria. Other studies have also shown that garlic extract has good dentin penetration properties as well as ideal flow and wetting capabilities. Conclusion: Garlic (Allium sativum L.) extract has good antimicrobial efficacy, dentin penetration, as well as ideal properties of root canal irrigation in endodontic treatment
Effect of chitosan–hydroxyapatite scaffolds seeded with cryopreserved hADMSCs on bone sialoprotein secretion Kamadjaja, Michael Josef Kridanto; Kuntjoro, Mefina; Pratiwi, Chandrasasi Berlian; Hartanli, Audrey Luisa
Majalah Kedokteran Gigi Indonesia Vol 11, No 3 (2025): December
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/majkedgiind.110209

Abstract

Tooth extraction can lead to alveolar bone resorption, requiring regenerative approaches using biomaterial scaffolds combined with stem cells. Chitosan–hydroxyapatite (CS–HA), a well-established scaffold that mimics the composition of human bone, combined with stem cells represents a promising strategy to promote bone formation. This study aimed to evaluate the effect of chitosan–hydroxyapatite (CS-HA) scaffolds seeded with cryopreserved human adipose-derived mesenchymal stem cells (hADMSCs) on bone sialoprotein (BSP) secretion. The hADMSCs used in this study were commercially obtained cryopreserved cells (ATCC® PCS-500-011™) and were characterized by flow cytometry. Scaffolds were fabricated using a freeze-drying method by combining chitosan and hydroxyapatite in a 1 : 1 ratio, followed by freezing at −80 °C. A post-test-only control group design was employed, consisting of 36 samples divided into three groups: positive control (CS-HA + hADMSCs + a-MEM), negative control (hADMSCs + osteogenic medium), and treatment (CS-HA + hADMSCs + osteogenic medium), and BSP levels were subsequently quantified on days 7, 14, 21, and 28 using ELISA. One-way ANOVA demonstrated a significant difference among groups (p = 0.000), with the highest BSP secretion observed in treatment group on day 14 (BSP levels 44.29 ± 2.58), followed by treatment group on day 28 (BSP levels 46.19 ± 7.64).  The significantly elevated BSP secretion in the treatment group on day 14 demonstrates osteoinductive characteristics of the CS-HA scaffold, supporting its potential application in bone tissue engineering and regeneration.
Effect of chitosan–hydroxyapatite scaffolds seeded with cryopreserved hADMSCs on bone sialoprotein secretion Kamadjaja, Michael Josef Kridanto; Kuntjoro, Mefina; Pratiwi, Chandrasasi Berlian; Hartanli, Audrey Luisa
Majalah Kedokteran Gigi Indonesia Vol 11, No 3 (2025): December
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/majkedgiind.110209

Abstract

Tooth extraction can lead to alveolar bone resorption, requiring regenerative approaches using biomaterial scaffolds combined with stem cells. Chitosan–hydroxyapatite (CS–HA), a well-established scaffold that mimics the composition of human bone, combined with stem cells represents a promising strategy to promote bone formation. This study aimed to evaluate the effect of chitosan–hydroxyapatite (CS-HA) scaffolds seeded with cryopreserved human adipose-derived mesenchymal stem cells (hADMSCs) on bone sialoprotein (BSP) secretion. The hADMSCs used in this study were commercially obtained cryopreserved cells (ATCC® PCS-500-011™) and were characterized by flow cytometry. Scaffolds were fabricated using a freeze-drying method by combining chitosan and hydroxyapatite in a 1 : 1 ratio, followed by freezing at −80 °C. A post-test-only control group design was employed, consisting of 36 samples divided into three groups: positive control (CS-HA + hADMSCs + a-MEM), negative control (hADMSCs + osteogenic medium), and treatment (CS-HA + hADMSCs + osteogenic medium), and BSP levels were subsequently quantified on days 7, 14, 21, and 28 using ELISA. One-way ANOVA demonstrated a significant difference among groups (p = 0.000), with the highest BSP secretion observed in treatment group on day 14 (BSP levels 44.29 ± 2.58), followed by treatment group on day 28 (BSP levels 46.19 ± 7.64).  The significantly elevated BSP secretion in the treatment group on day 14 demonstrates osteoinductive characteristics of the CS-HA scaffold, supporting its potential application in bone tissue engineering and regeneration.
Co-Authors Aryandhita, Amanda Paramitha Putri Farizaldi, Reisya Irfanny Febriastuti Cahyani Mefina Kuntjoro Michael Josef Kridanto Kamadjaja Pratiwi, Chandrasasi Berlian Syafaati, Lailatul Maghfiroh