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EFFECTIVENESS OF MAGNESIUM CITRATE ADJUNCTIVE THERAPY ON CRAMPING PAIN INTENSITY IN NOCTURNAL LEG CRAMPS PATIENTS AT BETHESDA HOSPITAL YOGYAKARTA Digdoyo, Ananda; Pinzon, Rizaldy Taslim; Pramudita, Esdras Ardi
Jurnal Farmasi Sains dan Praktis Vol 10 No 1 (January-April 2024)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v10i1.9534

Abstract

Nocturnal Leg Cramps (NLC) are involuntary lower limb contractions that are painful and occur during long rest periods. Magnesium is thought to have potential in the treatment of NLC as one of the precipitating factors of NLC is low levels of certain minerals, such as magnesium deficiency. This study aimed to assess the effectiveness of magnesium adjunctive therapy in reducing cramping pain intensity in patients with NLC. This study was a randomized clinical trial, open-label, controlled group that was followed up for 2 weeks. 30 subjects who have been diagnosed with the NLC short-form adaptation of ICSD 2005 were divided into 2 groups; (1) the intervention group who was given standard NLC therapy (calcium and gabapentin) with additional therapy of magnesium citrate 100 mg (Hi-Mg100) one tablet a day, (2) the control group who was only given standard NLC therapy. NLC cramping pain was measured using the Numeric Rating Scale (NRS) before the administration of therapy (baseline) and at week 2 after therapy. The results obtained were the addition of magnesium to standard therapy provided a significant reduction in cramping pain intensity between before and after treatment based on the Wilcoxon signed rank test (p=0.000). However, there was no statistically significant difference effect between the two therapy groups based on the Mann-Whitney test (p=0.073). In conclusion, magnesium adjunctive therapy was not significantly more effective in reducing cramping pain than standard drug therapy in patients with NLC.
Posterior Reversible Encephalopathy Syndrome Secondary to Mild Renal Artery Stenosis induced Hypertension in Child: A Case Report Martelina, Yiska; Ananda Digdoyo; Wikrama, Ketut Wiswa
Acta Neurologica Indonesia Vol. 3 No. 01 (2025): Acta Neurologica Indonesia
Publisher : Departemen Neurologi Fakultas Kedokteran Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69868/ani.v3i01.44

Abstract

Introduction: In addition to neurological symptoms such as impaired consciousness that can result in the rare incidence of a comatose state, seizures, and visual impairment, posterior reversible encephalopathy syndrome (PRES) is represented by a various type of non-specific symptoms such as headache, nausea, and vomiting. These clinical features are associated with distinctive imaging findings of vasogenic edema, primarily located in the bilateral posterior or parieto-occipital lobes, which is generally reversible. Case Report: We present here, a young 7-years-old girl, with a medical history of hypertension, sudden loss of consciousness lasting 1 minute, stereotypic seizures lasting 5 to 10 seconds with unknown etiology, had a history of blurred vision for approximately 24 hours after the seizures, multiple projectile vomiting, dizziness and altered mental status for 1 week. The characteristics of vasogenic edema observed in the bilateral parieto-occipital lobe, as seen in CT-scan imaging, along with the reversal of symptoms, contributed to the diagnosis of PRES in our patient. After the hypertension was treated and the symptoms were reversed, the patient was discharged in a stable condition. Conclusion: We report a case is a Posterior Reversible Encephalopathy Syndrome in young patient caused by hypertension and triggered by renal artery stenosis. Hypertension must be treated in patients with neurological symptoms like loss of consciousness, dizziness, and blurred vision. Suspicion of PRES must be considered a special case.
Idiopathic Pulmonary Fibrosis Mimics Pulmonary Malignancy: A Case Report Wiswa Wikrama, Ketut; Boromeus Tabuni, Carolus; Digdoyo, Ananda; Nanda Pratama Putra, Putu; Gusti Parikesit, Petra; Darmoredjo, Sutaryanu
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 4 (2025): November 2025 ( Indonesia - Thailand)
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i4.508

Abstract

Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease characterized by extracellular matrix accumulation, often mimicking pulmonary malignancy in clinical and radiological aspects. Early and accurate diagnosis remains a challenge. Objective: To report a case of IPF presenting with hemoptysis and radiological features suggestive of malignancy, highlighting diagnostic complexities. Methods: This qualitative case study involved detailed clinical, radiological, and histopathological examination of a 60-year-old female patient. Data were collected through medical records, CT imaging, biopsies, and interviews. Thematic content analysis ensured rigorous interpretation. Results: Radiologic findings indicated suspicious masses bilaterally, yet histopathology confirmed pulmonary fibrosis without malignancy. This underscores the overlap in presentation and diagnostic ambiguity between IPF and lung cancer. Conclusion: Multimodal diagnostic approaches combining imaging and biopsy are essential to distinguish IPF from malignancy and to guide treatment. Increased clinician awareness and multidisciplinary collaboration enhance diagnostic accuracy and prognosis. Further research with larger samples is recommended to improve non-invasive diagnostic tools.
Analysis of Organizational Design Effectiveness in Enhancing Hospital Performance and Adaptability: A Systematic Review Ananda Digdoyo; Rinawati Rinawati
Jurnal Ekonomi, Manajemen, Akuntansi dan Keuangan Vol. 6 No. 4 (2025): Oktober
Publisher : Penerbit Jurnal Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53697/emak.v6i4.3231

Abstract

The complex dynamics of the healthcare environment require hospitals to have an effective organizational design to achieve superior performance and high adaptability. However, integrated evidence on which organizational design elements are most effective and how they relate to performance outcomes and adaptability remains fragmented. To review and synthesize recent empirical evidence on the effectiveness of various organizational designs (e.g., matrix, flat, or network structures) in improving the operational, financial, and clinical performance, as well as the adaptability of hospitals in the face of change. This systematic review will be conducted following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. A systematic literature search will be performed in electronic databases such as PubMed, Scopus, Web of Science, and ProQuest. Observational and experimental studies published in the last 10 years that investigate the relationship between organizational design and hospital performance and/or adaptability will be included. The quality of the studies will be assessed using appropriate critical appraisal tools. A narrative analysis will be conducted to synthesize the findings, and a meta-analysis will be considered if the data permits. (This section will be completed after the review. Example: "Out of 2,350 identified studies, 35 met the inclusion criteria. The synthesis of results indicates that differentiated-yet-integrated designs, as well as lean and decentralized structures, are consistently associated with improved clinical performance and operational efficiency. Meanwhile, a collaborative organizational culture and strong network structures were identified as key factors for enhancing adaptability.") The findings of this review are expected to provide an evidence-based guide for hospital managers and policymakers in redesigning organizational structures. Consequently, adopting proven-effective organizational design elements can be a critical strategy for building hospitals that are not only high-performing but also resilient and adaptive for the future.
Unexpected Encephalitis in Active Miliary TB Undergoing Treatment in an Elderly Person: A Rare Case Report Digdoyo, Ananda; Tabuni, Carolus Boromeus; Wikrama, Ketut Wiswa; Putra, Putu Nanda Pratama; Atmoko, Mahendra Bagus Dwi; Sudharmadji, Sudharmadji
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS Vol. 5 No. 2 (2026): APRIL
Publisher : Transpublika Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55047/comorbid.v5i2.2093

Abstract

Miliary tuberculosis (TB) with central nervous system (CNS) involvement manifesting as unexpected encephalitis in the elderly is a rare and serious condition. This study aims to describe and analyze the clinical manifestations of unexpected encephalitis in elderly patients with active miliary TB undergoing treatment. A descriptive case study with a qualitative approach was used. The population was elderly patients diagnosed with active miliary TB complicated by CNS involvement, with a purposive sample of one 68-year-old female patient who presented with atypical neurological symptoms after approximately five weeks of multidrug therapy (MDT). Data were obtained from medical records, neurological physical examinations, laboratory results, and head CT scans. A narrative descriptive analysis integrated clinical and radiological findings to interpret the relationship between encephalitis manifestations and TB therapy progression. The results showed atypical encephalitis symptoms with CT evidence of hypodense lesions and central calcifications, highlighting the diagnostic challenge. Appropriate MDT therapy with adjuvant corticosteroids resulted in a good clinical response. The conclusions emphasize the importance of early detection and use of neuroimaging in elderly patients with miliary TB to reduce neurological complications. Further research with larger samples is recommended to strengthen the findings.