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All Journal Jurnal Farmasi Sains dan Praktis Acta Neurologica Indonesia
Digdoyo, Ananda
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Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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EFFECTIVENESS OF MAGNESIUM CITRATE ADJUNCTIVE THERAPY ON CRAMPING PAIN INTENSITY IN NOCTURNAL LEG CRAMPS PATIENTS AT BETHESDA HOSPITAL YOGYAKARTA Digdoyo, Ananda; Pinzon, Rizaldy Taslim; Pramudita, Esdras Ardi
Jurnal Farmasi Sains dan Praktis Vol 10 No 1 (January-April 2024)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v10i1.9534

Abstract

Nocturnal Leg Cramps (NLC) are involuntary lower limb contractions that are painful and occur during long rest periods. Magnesium is thought to have potential in the treatment of NLC as one of the precipitating factors of NLC is low levels of certain minerals, such as magnesium deficiency. This study aimed to assess the effectiveness of magnesium adjunctive therapy in reducing cramping pain intensity in patients with NLC. This study was a randomized clinical trial, open-label, controlled group that was followed up for 2 weeks. 30 subjects who have been diagnosed with the NLC short-form adaptation of ICSD 2005 were divided into 2 groups; (1) the intervention group who was given standard NLC therapy (calcium and gabapentin) with additional therapy of magnesium citrate 100 mg (Hi-Mg100) one tablet a day, (2) the control group who was only given standard NLC therapy. NLC cramping pain was measured using the Numeric Rating Scale (NRS) before the administration of therapy (baseline) and at week 2 after therapy. The results obtained were the addition of magnesium to standard therapy provided a significant reduction in cramping pain intensity between before and after treatment based on the Wilcoxon signed rank test (p=0.000). However, there was no statistically significant difference effect between the two therapy groups based on the Mann-Whitney test (p=0.073). In conclusion, magnesium adjunctive therapy was not significantly more effective in reducing cramping pain than standard drug therapy in patients with NLC.
Posterior Reversible Encephalopathy Syndrome Secondary to Mild Renal Artery Stenosis induced Hypertension in Child: A Case Report Martelina, Yiska; Ananda Digdoyo; Wikrama, Ketut Wiswa
Acta Neurologica Indonesia Vol. 3 No. 01 (2025): Acta Neurologica Indonesia
Publisher : Departemen Neurologi Fakultas Kedokteran Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69868/ani.v3i01.44

Abstract

Introduction: In addition to neurological symptoms such as impaired consciousness that can result in the rare incidence of a comatose state, seizures, and visual impairment, posterior reversible encephalopathy syndrome (PRES) is represented by a various type of non-specific symptoms such as headache, nausea, and vomiting. These clinical features are associated with distinctive imaging findings of vasogenic edema, primarily located in the bilateral posterior or parieto-occipital lobes, which is generally reversible. Case Report: We present here, a young 7-years-old girl, with a medical history of hypertension, sudden loss of consciousness lasting 1 minute, stereotypic seizures lasting 5 to 10 seconds with unknown etiology, had a history of blurred vision for approximately 24 hours after the seizures, multiple projectile vomiting, dizziness and altered mental status for 1 week. The characteristics of vasogenic edema observed in the bilateral parieto-occipital lobe, as seen in CT-scan imaging, along with the reversal of symptoms, contributed to the diagnosis of PRES in our patient. After the hypertension was treated and the symptoms were reversed, the patient was discharged in a stable condition. Conclusion: We report a case is a Posterior Reversible Encephalopathy Syndrome in young patient caused by hypertension and triggered by renal artery stenosis. Hypertension must be treated in patients with neurological symptoms like loss of consciousness, dizziness, and blurred vision. Suspicion of PRES must be considered a special case.
Co-Authors Esdras Ardi Pramudita, Esdras Ardi Martelina, Yiska Rizaldy Pinzon Wikrama, Ketut Wiswa