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All Journal Open Access Indonesian Journal of Medical Reviews Cermin Dunia Kedokteran
Rizkia, Chaula Putri
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Health Professions Medicine & Pharmacology

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Peran Vaksin Rotavirus terhadap Penurunan Jumlah Kasus dan Lama Rawat Anak dengan Diare: Analisis Devana, Natasha Dianasari; Rizkia, Chaula Putri
Cermin Dunia Kedokteran Vol 52 No 9 (2025): Pediatri
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i9.1609

Abstract

Diarrhea remains one of the leading causes of morbidity and mortality among children in developing countries, including Indonesia. One of the most common causes of severe acute diarrhea is rotavirus infection, which is highly contagious through the fecal-oral route and can lead to severe dehydration and even death. Efective prevention can be achieved through rotavirus vaccination, which has been proven to reduce incidence, prevent transmission, and decrease disease severity. Rotavirus vaccination in children is known to be benefcial in controlling cases of rotavirus diarrhea, and since 2023, the rotavirus vaccine has been part of Indonesia's national immunization program, provided free of charge to infants according to the Ministry of Health's immunization schedule. Multiple studies have shown that this immunization reduces the risk of serious complications, shortens hospital stays, decreases hospitalization rates, and lessens the economic burden on families due to medical costs and lost productivity. Broad implementation of rotavirus vaccination is therefore a key strategy to improve child health and reduce diarrhea-related mortality in Indonesia.
Vitamin D and Its Role in Modulating Immune System: A Narrative Literature Review Rizkia, Chaula Putri
Open Access Indonesian Journal of Medical Reviews Vol. 3 No. 1 (2023): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v3i1.282

Abstract

Vitamin D is recognized for its pivotal role in maintaining calcium-phosphorus homeostasis and regulating bone metabolism. The beneficial effects of vitamin D on the protective function of the immune system are seen in the innate immune system. It increases the production of defensin β2 and cathelicidin by macrophages, monocytes, and keratinocytes in response to infection. Cathelicidin is produced by neutrophils, macrophages, and cells lining epithelial surfaces such as skin, respiratory, and digestive tracts. Recent research showed that vitamin D exerts potent immunomodulatory effects by modulating the innate and adaptive immune systems. This led to the recognition of various disease conditions associated with vitamin D deficiency. This narrative review aimed to describe the molecular mechanisms for the vitamin D immunomodulatory effect.
Co-Authors Devana, Natasha Dianasari