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All Journal Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Cermin Dunia Kedokteran
Devana, Natasha Dianasari
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Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Public Health

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Peran Vaksin Rotavirus terhadap Penurunan Jumlah Kasus dan Lama Rawat Anak dengan Diare: Analisis Devana, Natasha Dianasari; Rizkia, Chaula Putri
Cermin Dunia Kedokteran Vol 52 No 9 (2025): Pediatri
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i9.1609

Abstract

Diarrhea remains one of the leading causes of morbidity and mortality among children in developing countries, including Indonesia. One of the most common causes of severe acute diarrhea is rotavirus infection, which is highly contagious through the fecal-oral route and can lead to severe dehydration and even death. Efective prevention can be achieved through rotavirus vaccination, which has been proven to reduce incidence, prevent transmission, and decrease disease severity. Rotavirus vaccination in children is known to be benefcial in controlling cases of rotavirus diarrhea, and since 2023, the rotavirus vaccine has been part of Indonesia's national immunization program, provided free of charge to infants according to the Ministry of Health's immunization schedule. Multiple studies have shown that this immunization reduces the risk of serious complications, shortens hospital stays, decreases hospitalization rates, and lessens the economic burden on families due to medical costs and lost productivity. Broad implementation of rotavirus vaccination is therefore a key strategy to improve child health and reduce diarrhea-related mortality in Indonesia.
Peptida Antimikrobial Cathelicidin dan Hubungannya terhadap Vitamin D dalam Masa Pandemi COVID-19 Devana, Natasha Dianasari; Mudjihartini, Ninik
Majalah Kedokteran Indonesia Vol 72 No 6 (2022): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.72.6-2022-923

Abstract

A peptide known as antimicrobial peptide (AMP) possesses antimicrobial effects against bacteria, fungus and viruses. AMP, also known as Host Defense Protein (HDP), is one of the body's defense mechanisms since it has the capacity to actively kill viruses. When it comes to respiratory cells, which are the major target of the SARS CoV-2 virus that produces COVID-19, cathelicidin, a kind of AMP in humans, is known to have protective properties. Cathelicidin AMP performance represents the first-line action of the natural immune system, with cathelicidin synthesis linked to appropriate vitamin D levels. Numerous earlier studies have discovered a connection between low cathelicidin levels and low vitamin D levels; this underlines the significance of vitamin D levels in strengthening the immune system. Naturally, particularly for the production of cathelicidin, which serves as the body's primary line of defense during the COVID-19 pandemic.
Co-Authors Ninik Mudjihartini Rizkia, Chaula Putri