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p-Index From 2020 - 2025
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All Journal Community Medicine and Education Journal Scientific Journal of Dermatology and Venereology
Nazeera Hamid
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Humanities Education Health Professions Languange, Linguistic, Communication & Media Public Health

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Unraveling the Genetic Landscape of Psoriasis: A Genome-Wide Association Study in Egypt Abd El Nasser; Nazeera Hamid
Scientific Journal of Dermatology and Venereology Vol. 3 No. 1 (2025): Scientific Journal of Dermatology and Venereology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjdv.v2i2.157

Abstract

Introduction: Psoriasis is a chronic inflammatory skin disease with a complex genetic basis. While Genome-Wide Association Studies (GWAS) have identified numerous susceptibility loci in European populations, the genetic landscape of psoriasis in Egyptians remains largely unexplored. Methods: The study conducted a GWAS in a cohort of 1,200 Egyptian individuals (600 cases and 600 controls) using the Illumina Infinium Global Screening Array-24 v3.0 BeadChip. After stringent quality control, association analyses were performed using logistic regression, adjusting for age, sex, and principal components. Replication of top signals was attempted in an independent cohort of 500 Egyptian individuals (250 cases and 250 controls). Functional annotation and pathway enrichment analyses were performed to gain insights into the biological relevance of associated loci. Results: We identified novel genome-wide significant associations in the HLA region (rs10484554: p = 1.2 x 10^-15, OR = 2.3) and near the IL23R gene (rs11209026: p = 3.5 x 10^-9, OR = 1.7). These associations were replicated in the independent cohort. Additionally, we observed suggestive associations near several genes previously implicated in psoriasis, including IL12B, TRAF3IP2, and CARD14. Pathway enrichment analyses highlighted the involvement of immune response, cytokine signaling, and keratinocyte differentiation pathways. Conclusion: This GWAS in Egyptians has revealed novel psoriasis susceptibility loci and replicated previously reported associations, contributing to a better understanding of the genetic architecture of psoriasis in this population. These findings may have implications for the development of personalized treatment strategies.
The Impact of Health Policy on Community-Based Palliative Care Services: A Mixed-Methods Evaluation in Bandung, Indonesia Dea Albertina; Istiqomah Putri; Nazeera Hamid; Cindy Susanti
Community Medicine and Education Journal Vol. 6 No. 1 (2025): Community Medicine and Education Journal
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/cmej.v6i1.697

Abstract

Palliative care is a crucial component of comprehensive healthcare, yet access to community-based palliative care services remains limited in many low- and middle-income countries, including Indonesia. This study aimed to evaluate the impact of existing health policies on community-based palliative care in Bandung, Indonesia. A mixed-methods approach was employed, combining quantitative and qualitative data collection and analysis. Quantitative data included a retrospective analysis of patient records (n=350) from three community-based palliative care providers in Bandung from 2018-2023, assessing referral patterns, service utilization, and patient demographics. Qualitative data were gathered through semi-structured interviews with policymakers (n=10), healthcare providers (n=15), and patients/caregivers (n=20) to explore their perspectives on policy implementation and its impact. Data were analyzed using descriptive statistics, thematic analysis, and a framework approach guided by the WHO Health Systems Framework. The study found that while national health policies acknowledge the importance of palliative care, significant gaps exist in implementation at the local level. The number of patients accessing community-based palliative care increased modestly from 45 in 2018 to 78 in 2023, but this represents a small fraction of the estimated need. Key policy-related barriers identified included: limited funding allocated specifically for community-based palliative care , inadequate training and workforce capacity in palliative care, lack of standardized referral pathways from hospitals to community-based services and limited public awareness of palliative care. In conclusion, health policies in Indonesia have not yet translated into widespread access to quality community-based palliative care in Bandung. Strengthened policy implementation, increased funding, workforce development, improved referral systems, and enhanced public awareness are crucial to address this gap and improve the quality of life for patients with life-limiting illnesses and their families.
Co-Authors Abd El Nasser Cindy Susanti Dea Albertina Istiqomah Putri