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All Journal Scientific Journal of Dermatology and Venereology Sriwijaya Journal of Otorhinolaryngology
Abd El Nasser
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Public Health

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Unraveling the Genetic Landscape of Psoriasis: A Genome-Wide Association Study in Egypt Abd El Nasser; Nazeera Hamid
Scientific Journal of Dermatology and Venereology Vol. 3 No. 1 (2025): Scientific Journal of Dermatology and Venereology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjdv.v2i2.157

Abstract

Introduction: Psoriasis is a chronic inflammatory skin disease with a complex genetic basis. While Genome-Wide Association Studies (GWAS) have identified numerous susceptibility loci in European populations, the genetic landscape of psoriasis in Egyptians remains largely unexplored. Methods: The study conducted a GWAS in a cohort of 1,200 Egyptian individuals (600 cases and 600 controls) using the Illumina Infinium Global Screening Array-24 v3.0 BeadChip. After stringent quality control, association analyses were performed using logistic regression, adjusting for age, sex, and principal components. Replication of top signals was attempted in an independent cohort of 500 Egyptian individuals (250 cases and 250 controls). Functional annotation and pathway enrichment analyses were performed to gain insights into the biological relevance of associated loci. Results: We identified novel genome-wide significant associations in the HLA region (rs10484554: p = 1.2 x 10^-15, OR = 2.3) and near the IL23R gene (rs11209026: p = 3.5 x 10^-9, OR = 1.7). These associations were replicated in the independent cohort. Additionally, we observed suggestive associations near several genes previously implicated in psoriasis, including IL12B, TRAF3IP2, and CARD14. Pathway enrichment analyses highlighted the involvement of immune response, cytokine signaling, and keratinocyte differentiation pathways. Conclusion: This GWAS in Egyptians has revealed novel psoriasis susceptibility loci and replicated previously reported associations, contributing to a better understanding of the genetic architecture of psoriasis in this population. These findings may have implications for the development of personalized treatment strategies.
The Influence of Traditional Indonesian Practices (Jamu) on the Prevention and Management of Common Otorhinolaryngology Complaints: A Mixed-Methods Study Fifia Ardinanti; Brian Edgar Wicaksana; Rizki Ayu; Mohammad Arfin; Abd El Nasser
Sriwijaya Journal of Otorhinolaryngology Vol. 2 No. 2 (2024): Sriwijaya Journal of Otorhinolaryngology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjorl.v3i1.189

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Introduction: In Indonesia, jamu (traditional herbal medicine) is culturally significant for health maintenance, including managing common ear, nose, and throat (ENT) complaints. This study explored the influence of jamu on the prevention and management of these complaints by examining patient beliefs, usage patterns, perceived outcomes, and associations with conventional healthcare-seeking. Methods: A mixed-methods sequential explanatory design was used. A cross-sectional survey of 1200 Indonesian adults assessed demographics, ENT complaint prevalence, jamu use (type, frequency, perceived effectiveness), and healthcare seeking. Subsequently, semi-structured interviews were conducted with 30 survey participants who regularly used jamu for ENT issues to explore their beliefs and experiences. Quantitative data were analyzed using descriptive statistics, chi-square tests, and logistic regression. Qualitative data underwent thematic analysis. Results: Survey data showed 68.5% experienced ENT complaints in the past year, with sore throat (42.3%), cough (38.7%), and nasal congestion (31.2%) most common. Among them, 53.2% used jamu, primarily turmeric-based for sore throat and ginger-based for cough and congestion. Regular jamu use was associated with perceived symptom relief (p < 0.001) but also with a higher likelihood of delaying conventional care for persistent symptoms (OR = 1.85). Interviews revealed strong cultural beliefs in jamu's efficacy and safety for mild ENT issues, often used as a first-line treatment due to its natural origin, fewer perceived side effects, and affordability. However, some acknowledged its limitations for severe conditions. Conclusion: Jamu plays a significant role in managing common ENT complaints in Indonesia, driven by strong cultural beliefs and perceived benefits. While users report symptom relief, delayed access to conventional care for serious conditions is a potential concern. Further research is needed to scientifically evaluate specific jamu formulations and develop integrated usage guidelines in Indonesia.
Co-Authors Brian Edgar Wicaksana Fifia Ardinanti Mohammad Arfin Nazeera Hamid Rizki Ayu