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All Journal Jurnal MedScientiae
Rumawas, Marina Astrid
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Review of the Effectiveness and Safety of Secukinumab Administration for the Treatment of Moderate to Severe Plaque Psoriasis Mahariska, Dina Fitria; Rumawas, Marina Astrid; William, William; bah, Yasavati Kurnia
Jurnal MedScientiae Vol. 3 No. 1 (2024): April
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Ukrida

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i1.2916

Abstract

Psoriasis is a chronic recurrent inflammation of the skin caused by excessive activity of the immune system. Based on data from WHO psoriasis cases are 0.09% - 11.43%, while in Indonesia it reaches 2.5% of the total population. Of the various types of psoriasis, the most common is plaque psoriasis or psoriasis vulgaris, up to 90%. The severity of moderate to severe plaque psoriasis is a problem because it affects both physical and psychological life. This study review aims to determine the effectiveness and safety of treatment with secukinumab in moderate to severe plaque psoriasis. Secukinumab is the choice because the main target of this biological agent is to neutralize IL-17A. Secukinumab is available in Indonesia and was approved by the FDA in 2015. Parameters of treatment success were seen from the PASI, DLQI and BSA scores. Side effects that often occur are nasopharyngitis, skin infections, upper respiratory tract infections and gastrointestinal disorders.
Rasionalitas Penggunaan Obat Benzodiazepine oleh Dokter Selama 10 Tahun Terakhir: Sebuah Literature Review Anughrahani, Lilie; Wijaya, Diana; Ndraha, Suzanna; Rumawas, Marina Astrid
Jurnal MedScientiae Vol. 4 No. 2 (2025): Agustus
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jmedscientiae.v4i2.3651

Abstract

Mental disorders have become a common problem globally. The World Health Organization shows that more than one in six people experienced mental health problems in 2016. Benzodiazepines, a drug that has been on the market since 1957, are often used to treat mental and behavior-related problems. Although effective for certain conditions, long-term use of benzodiazepines can cause significant side effects. Health regulations and guidelines suggest that treatment with benzodiazepines should be carried out rationally with reference to the Decree of the Minister of Health of the Republic of Indonesia in 2021 concerning the National Formulary. This literature aims to conduct a review to evaluate the rationality of the use of benzodiazepines by doctors in various countries over the past ten years. The method in this study is to search for articles through Google Scholar and Pubmed. The results obtained were that benzodiazepines are generally used to treat anxiety and sleep disorders. The maximum dose, which is according to the national formulary and the Food and Drug Administration, does not have a significant difference. Challenges that need to be addressed involve aspects of prescribing, such as ensuring the recipe is in accordance with the right indications, adhering to dosage restrictions, and paying attention to the maximum duration of use. Therefore, there needs to be clear rules to regulate this, supported by active socialization efforts to increase doctors' understanding and compliance with more rational prescribing practices.  
Co-Authors Anughrahani, Lilie bah, Yasavati Kurnia Diana Wijaya Mahariska, Dina Fitria Suzanna Ndraha William William