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Rumawas, Marina Astrid
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Review of the Effectiveness and Safety of Secukinumab Administration for the Treatment of Moderate to Severe Plaque Psoriasis Mahariska, Dina Fitria; Rumawas, Marina Astrid; William, William; bah, Yasavati Kurnia
Jurnal MedScientiae Vol 3 No 1 (2024): April
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i1.2916

Abstract

Psoriasis is a chronic recurrent inflammation of the skin caused by excessive activity of the immune system. Based on data from WHO psoriasis cases are 0.09% - 11.43%, while in Indonesia it reaches 2.5% of the total population. Of the various types of psoriasis, the most common is plaque psoriasis or psoriasis vulgaris, up to 90%. The severity of moderate to severe plaque psoriasis is a problem because it affects both physical and psychological life. This study review aims to determine the effectiveness and safety of treatment with secukinumab in moderate to severe plaque psoriasis. Secukinumab is the choice because the main target of this biological agent is to neutralize IL-17A. Secukinumab is available in Indonesia and was approved by the FDA in 2015. Parameters of treatment success were seen from the PASI, DLQI and BSA scores. Side effects that often occur are nasopharyngitis, skin infections, upper respiratory tract infections and gastrointestinal disorders.
Rasionalitas Penggunaan Obat Benzodiazepine oleh Dokter Selama 10 Tahun Terakhir: Sebuah Literature Review Anughrahani, Lilie; Wijaya, Diana; Ndraha, Suzanna; Rumawas, Marina Astrid
Jurnal MedScientiae Vol 4 No 2 (2025): August
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jmedscientiae.v4i2.3651

Abstract

Mental disorders have become a common problem globally. The World Health Organization shows that more than one in six people experienced mental health problems in 2016. Benzodiazepines, a drug that has been on the market since 1957, are often used to treat mental and behavior-related problems. Although effective for certain conditions, long-term use of benzodiazepines can cause significant side effects. Health regulations and guidelines suggest that treatment with benzodiazepines should be carried out rationally with reference to the Decree of the Minister of Health of the Republic of Indonesia in 2021 concerning the National Formulary. This literature aims to conduct a review to evaluate the rationality of the use of benzodiazepines by doctors in various countries over the past ten years. The method in this study is to search for articles through Google Scholar and Pubmed. The results obtained were that benzodiazepines are generally used to treat anxiety and sleep disorders. The maximum dose, which is according to the national formulary and the Food and Drug Administration, does not have a significant difference. Challenges that need to be addressed involve aspects of prescribing, such as ensuring the recipe is in accordance with the right indications, adhering to dosage restrictions, and paying attention to the maximum duration of use. Therefore, there needs to be clear rules to regulate this, supported by active socialization efforts to increase doctors' understanding and compliance with more rational prescribing practices.  
The Pengaruh Suplementasi Vitamin D Bagi Ibu Hamil: Indonesia Lazuardi, Rachel Putri Clarissa; Rumawas, Marina Astrid; Wijaya, Diana
Jurnal MedScientiae Vol 2 No 3 (2023): December
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v2i3.2920

Abstract

Large epidemiological studies reveal high prevalence of vitamin D deficiency in women, antenatal and breastfeeding mothers. Recent studies found role for vitamin D in pregnancy disorders and complications. This research is a literature review. Literatures was retrieved from Google Scholar, PubMed and Biomed Central, a total of 620 journals, after passing inclusion and exclusion factors, 13 journals were found to be appropriate. Research shows the association of vitamin D deficiency in pregnant women with pre-eclampsia, IUGR, recurrent miscarriage, placental inflammation, gestational diabetes mellitus and bacterial vaginosis. Ali etal, found that total incidence of pre-eclampsia was lower through vitamin D supplementation at dose of 4000 IU/day during pregnancy. Zerofsky etal, found 2000 IU/day during pregnancy more effective for improving vitamin D status and associated with reduced risk of recurrent miscarriage and IUGR. Yin etal, found that vitamin D 600 IU/day during pregnancy significantly reduced risk of GDM. Taheri etal, found a 63.5% BV cure rate with two drops (2000 IU)/day of vitamin D3 oily solution in pregnant women. There is associations between vitamin D deficiency, abnormalities and complications of pregnancy. Giving 2000 IU to pregnant women was good for preventing the risk of pregnancy disorders and drops as the best preparation.
Tinjauan Pustaka: Potensi Aktivitas Antioksidan Spirulina sp Terhadap Penyakit-penyakit Metabolik dan Proses Degeneratif Patadan, Arya; Rumawas, Marina Astrid; Sudrajat, Susana Elya
Jurnal MedScientiae Vol 2 No 3 (2023): December
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v2i3.2978

Abstract

Free radicals are normal metabolites in the form of molecules of one or more unpaired electrons, so they are highly reactive and can cause cell damage and disrupt homeostasis. Depletion of antioxidants or accumulation of free radicals can cause oxidative stress, which plays a role in various disease processes such as inflammation, cancer, hemochromatosis, emphysema, high blood pressure to the aging process. Spirulina platensis is also known as blue-green filamentous algae because it is a colony-forming blue-green autotroph where columnar cells are arranged in columns to form twisted filaments resembling helices. C-Phycocyanin is one of the major groups of water-soluble and widely distributed phycobiliprotein in spirulina. The purpose of writing this literature review is to determine the potential antioxidant activity of Spirulina platensis against metabolic diseases and degenerative processes. This writing is in the form of a literature study by searching for data using two databases, Pudmed and Google Scholar. The keywords used are, Spirulina platensis, antioxidant activity, metabolic and degenerative diseases. After being selected based on inclusion and exclusion criteria, 21 references were obtained for review. Spirulina platensis has shown antioxidant, antidiabetic and antihypertensive effects in vitro and in vivo.
Gambaran Penderita Batu Empedu Di RSUD Tarakan Melalui Pemeriksaan Ultrasonografi Molle, Michel; Rumawas, Marina Astrid; Sutrisno, Sony; William, William
Jurnal MedScientiae Vol 5 No 2 (2026): August
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jmedscientiae.v5i2.4473

Abstract

Gallstones form from deposits of bile within the gallbladder. Gallstones can be detected via ultrasound examination to assess Murphy’s sign. Data on the incidence of gallstones in Indonesia itself is currently insufficient. This study aims to determine the profile of gallstone patients and their characteristics through  ultrasound examinations as well as their management at Tarakan Regional General Hospital. A descriptive cross-sectional study design using total sampling was applied to medical records from 2023. A sample of 97 individuals meeting the inclusion and exclusion criteria was obtained. The results are presented in tables and diagrams. A total of 64 patients (66.0%) were female, and 64 patients (66.1%) were aged 40 years or older. The group with a single stone was found in 78 patients (80.8%), whilst the highest frequency was observed in patients with medium-sized stones (5–10 mm), comprising 61 patients (62.89%). It can be concluded that patients with cholelithiasis at Tarakan General Hospital are more commonly found among women aged 40 years or older with medium-sized stones. The effectiveness of ursodeoxycholic acid in 12 patients could not be evaluated due to incomplete data. Meanwhile, surgical intervention for gallstone patients is based more on the onset of complaints or clinical symptoms, rather than on the size and number of gallstones.
Co-Authors Anughrahani, Lilie bah, Yasavati Kurnia Diana Wijaya Lazuardi, Rachel Putri Clarissa Mahariska, Dina Fitria Molle, Michel Patadan, Arya Sudrajat, Susana Elya Sutrisno, Sony Suzanna Ndraha William William