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Langi, Fima
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Nursing Public Health

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Relation of Pre-operative Ureteral Catheter Use and Complications of Intraoperative Ureteral and Bladder Trauma in Gynecologic Oncology Patients Undergoing Major Surgical Procedures Sinurat, Bintang; Toreh, Christof; Astram, Ari; Arianto, Eko; Langi, Fima
Medical Scope Journal Vol. 7 No. 1 (2025): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.v7i1.56265

Abstract

Iatrogenic injury to the urinary tract is a potential complication of all surgical procedures performed in or retroperitoneum and pelvis. Gynecological surgery in particular has a risk of urinary tract injury due to the close anatomy of the urinary tract and the reproductive system in women. This study aimed to evaluate the relation between pre-operative ureteral catheter use and complications of intraoperative ureteral and bladder trauma in gynaecologic oncology patients undergoing major surgical procedures. This study used cohort data of patients undergoing major surgical procedures at Prof. Dr. R. D. Kandou Hospital, Manado, recorded in medical records from January 1, 2023 to June 30, 2023. The bivariate test showed that patients who received pre-operative ureteral catheter insertion had fewer urological trauma events (4.5%) compared to patients who did not get pre-operative ureteral catheter (95.5%). The relations between pre-operative ureteral catheters and the incidence of urological trauma was found to be statistically significant with a p-value of 0.019 and the history of chemotherapy had a p-value of 0.036, meanwhile the relations with other variables showed p-values of >0.05. Therefore, the use of pre-operative catheters could not significantly eliminate the occurrence of ureteral trauma because many of the confounding factors were accompanied by several other conditions that were also studied in the multivariate analysis. In conclusion, there is no association between the use of pre-operative ureteral catheters and complications of intraoperative ureteral trauma in gynecologic oncology patients undergoing major surgical procedures. Future studies using samples from more sources are expected to assess the relation between pre-operative ureteral catheter use and the incidence of urological trauma more accurately, and to assess the ease of use of pre-operative ureteral catheter. Keywords: ureteral catheter; ureteral trauma; gynaecologic oncology patients
Rasio Neutrofil Limfosit sebagai Prediktor Kejadian Kebocoran Anastomosis pada Pasien Kanker Kolorektal Panelewen, Jimmy; Tendean, Michael; Langi, Fima; Akmal, Nuzly Q.
e-CliniC Vol. 12 No. 3 (2024): e-CliniC
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v12i3.58246

Abstract

Abstract: Anastomotic leakage is a serious complication following colorectal cancer resection that can increase morbidity and mortality. This study aimed to analyze the potential of the neutrophil-lymphocyte ratio (NLR) as a predictor of anastomotic leakage in colorectal cancer patients. This was a retrospective analytical and observational study involving 30 patients who underwent colorectal cancer resection and anastomosis at Prof. Dr. R. D. Kandou Hospital in Manado. The NLR values were analyzed preoperatively and on the first (D+1), third (D+3), fifth (D+5), and seventh (D+7) postoperative days. The results showed significant differences in NLR values between leakage and non-leakage groups across all phases (p<0.001). The receiver operating characteristic (ROC) curve analysis yielded optimal NLR cut-offs for leakage prediction: preoperative >2.1150, D+1 >3.4750, D+3 >2.7650, D+5 >3.0200, and D+7 >3.2850, with sensitivity and specificity reaching 100% in several phases. In conclusion, neutrophil-lymphocyte ratio has a potential as an accurate predictor of anastomotic leakage, enabling early detection and improved risk management. Further research with larger samples is needed to validate these findings and explore their clinical applications. Keywords: neutrophil-lymphocyte ratio; anastomotic leakage; colorectal cancer    Abstrak: Kebocoran anastomosis merupakan komplikasi serius pasca reseksi kanker kolorektal yang dapat meningkatkan morbiditas dan mortalitas. Penelitian ini bertujuan menganalisis potensi rasio neutrofil limfosit (RNL) sebagai prediktor kejadian kebocoran anastomosis pada pasien kanker kolorektal. Penelitian ini menggunakan metode observasional analitik retrospektif, melibatkan 30 pasien yang menjalani reseksi dan anastomosis kanker kolorektal di RSUP Prof. Dr. R. D. Kandou Manado. Nilai RNL dianalisis pada fase preoperatif, hari pertama (H+1), ketiga (H+3), kelima (H+5), dan ketujuh (H+7) pasca operasi. Hasil penelitian memperlihatkan perbedaan bermakna nilai RNL antara kelompok kebocoran dan tanpa kebocoran pada semua fase (p<0,001). Analisis kurva ROC menghasilkan cut-off optimal RNL untuk prediksi kebocoran: preoperatif >2,1150, H+1 >3,4750, H+3 >2,7650, H+5 >3,0200, dan H+7 >3,2850, dengan sensitivitas dan spesifisitas mencapai 100% pada beberapa fase. Simpulan penelitian ini ialah rasio neutrofil limfosit memiliki potensi sebagai prediktor yang akurat untuk kebocoran anastomosis, serta memungkinkan deteksi dini dan manajemen risiko yang lebih baik. Penelitian lebih lanjut dengan sampel yang lebih besar diperlukan untuk memvalidasi temuan ini dan mengeksplorasi aplikasi klinisnya. Kata kunci: rasio neutrofil limfosit; kebocoran anastomosis; kanker kolorektal
Co-Authors Akmal, Nuzly Q. Ari Astram, Ari ARIANTO, EKO Jimmy Panelewen, Jimmy Sinurat, Bintang Tendean, Michael Toreh, Christof