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All Journal Jurnal Biologi Tropis
Tuhfatul Ulya
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology

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Computational Toxicology: Endocrine Disrupting Effects of Lavender and Tea Tree Metabolites Selvira Anandia Intan Maulidya; Baiq Risky Wahyu Lisnasari; Indra Purnomo; Tuhfatul Ulya; Wayan Cintya Ganes Budastra
Jurnal Biologi Tropis Vol. 25 No. 2 (2025): April-Juni
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i2.9143

Abstract

While Lavandula angustifolia (lavender) and Melaleuca alternifolia (tea tree) are widely utilized in diverse products for their rich bioactive secondary metabolites, emerging evidence now fules concerns about their potential endocrine-disrupting activities. This study aimed to investigate the endocrine-disrupting potential of selected secondary metabolites from lavender and tea tree via an in silico molecular docking approach. Molecular interactions were evaluated against 18 human endrocine receptors using Endocrine Disruptome in silico tools and binding affinities were analyzed to assess potential toxicity. Docking analysis revealed that all lavender anda tea tree secondary metabolites have the potential to interact as androgen receptor antagonists, exhibiting minor, medium, and high probabilities of such activity. Additionally, more than 20% of lavender secondary metabolites and 10% of tea tree secondary metabolites are predicted to be capable of binding to the mineralocorticoid receptor, as well as thyroid receptors alpha and beta. These findings suggest a plausible mechanism by which these phytochemicals could exert endocrine-disruptor effects. In conclusion, the study provides preliminary computational evidence supporting the hypothesis that certain lavender and tea tree sceondary metabolites may act as endocrine-disrupting agents. Further in vitro and in vivo studies are warranted to assess their toxicological implications for long-term human exposure.
Literature Review: The Potential of Soft Coral Lobophytum sp. as a Source of Pharmaceutical Ingredients Indra Purnomo; Baiq Risky Wahyu Lisnasari; Tuhfatul Ulya; Selvira Anandia Intan Maulidya; Wayan Cintya Ganes Budastra
Jurnal Biologi Tropis Vol. 26 No. 1 (2026): Januari-Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v26i1.11469

Abstract

Lobophytum sp. is a soft coral found in Indonesian waters, mainly distributed on coral reef slopes. Lobophytum sp. contains various terpenoid compounds, including sesquiterpenes and terpenoid glycosides, which have a variety of biological activities. This literature review examines the pharmacological potential of Lobophytum sp. based on ten studies reporting its pharmacological activities, such as antibacterial, antimicrobial, hepatoprotective, anti-arthritic, antioxidant, anti-inflammatory, antimalarial, and neuroprotective properties. The diterpene cembranoids in Lobophytum sp. show potential as candidate active substances for the development of pharmaceutical products through various in vitro and in vivo studies. The antioxidant activity of cembranoids has the potential to be developed as an anti-aging agent. In addition, its anti-inflammatory, antibacterial, and cytotoxic activities can be developed in the form of topical preparations. However, the development of Lobophytum sp. As a source of active ingredients still faces various challenges, especially the limited isolation of cembranoids, which requires a biotechnological approach.
Co-Authors Awan Setiawan Baiq Risky Wahyu Lisnasari Indra Purnomo Indra Purnomo Selvira Anandia Intan Maulidya Toto Suharto Wayan Cintya Ganes Budastra