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All Journal Pharmaciana: Jurnal Kefarmasian Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang
Abusri, Mila
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Humanities Medicine & Pharmacology

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Effects of Piper crocatum leaf extract-based ointments on bacteria associated with diabetic ulcers: an in vitro study Nuari, Yudha Rizky; Abusri, Mila; Yuntari, Wahyu; Tryadi, Oca Maharani; Ardhiana, Fiarriescha Marra
Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i2.28653

Abstract

Diabetic patients with poor blood glucose control are highly susceptible to developing secondary infections, which can lead to the development of prolonged diabetic ulcers. Therefore, a suitable medication that may effectively prevent the occurrence of secondary infections is crucial to shorten the closure of diabetic ulcers. Red betel leaf (Piper crocatum Ruiz & Pav) reportedly possesses antimicrobial activity due to the presence of flavonoids. This study aimed to evaluate the effect of ethanolic extract of red betel leaf (EERBL) ointments against the most prevalent bacteria associated with diabetic foot ulcers (DFU): Staphylococcus aureus and Pseudomonas aeruginosa. The EERBL was prepared by macerating powdered red betel leaf with 96% ethanol and was screened for the presence of flavonoids and the determination of total flavonoid content (TFC) by thin layer chromatography and UV-Vis spectrophotometry, respectively. This study examined three hydrophilic-based ointments containing 10%, 20%, and 30% EERBL, respectively, followed by characterization for pH, spreadability, stickiness, and viscosity. The EERBL ointments' effect on the bacteria was evaluated using the well-diffusion method by observing inhibition zone formation after 24-hour incubation. The results showed that varying the EERBL concentrations in the formulations led to different spreadability, stickiness and viscosity (p<0.05). Furthermore, all EERBL ointments demonstrated the formation of an inhibition zone on cultured media, indicating the presence of antimicrobial activity. The ointment with 30% EERBL had the largest diameter of the inhibition zone against both bacteria (p<0.05). The findings suggest enhanced antimicrobial activity was observed with an increase in the concentration of EERBL within the ointments.
Effects of Piper crocatum leaf extract-based ointments on bacteria associated with diabetic ulcers: an in vitro study Nuari, Yudha Rizky; Abusri, Mila; Yuntari, Wahyu; Tryadi, Oca Maharani; Ardhiana, Fiarriescha Marra
Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i2.28653

Abstract

Diabetic patients with poor blood glucose control are highly susceptible to developing secondary infections, which can lead to the development of prolonged diabetic ulcers. Therefore, a suitable medication that may effectively prevent the occurrence of secondary infections is crucial to shorten the closure of diabetic ulcers. Red betel leaf (Piper crocatum Ruiz & Pav) reportedly possesses antimicrobial activity due to the presence of flavonoids. This study aimed to evaluate the effect of ethanolic extract of red betel leaf (EERBL) ointments against the most prevalent bacteria associated with diabetic foot ulcers (DFU): Staphylococcus aureus and Pseudomonas aeruginosa. The EERBL was prepared by macerating powdered red betel leaf with 96% ethanol and was screened for the presence of flavonoids and the determination of total flavonoid content (TFC) by thin layer chromatography and UV-Vis spectrophotometry, respectively. This study examined three hydrophilic-based ointments containing 10%, 20%, and 30% EERBL, respectively, followed by characterization for pH, spreadability, stickiness, and viscosity. The EERBL ointments' effect on the bacteria was evaluated using the well-diffusion method by observing inhibition zone formation after 24-hour incubation. The results showed that varying the EERBL concentrations in the formulations led to different spreadability, stickiness and viscosity (p<0.05). Furthermore, all EERBL ointments demonstrated the formation of an inhibition zone on cultured media, indicating the presence of antimicrobial activity. The ointment with 30% EERBL had the largest diameter of the inhibition zone against both bacteria (p<0.05). The findings suggest enhanced antimicrobial activity was observed with an increase in the concentration of EERBL within the ointments.
Cadre school-based elderly health assistance and screening for the prevention of non-communicable diseases Kusrinanti, Nabillah Ainun; Setyaningtyas, Padma Fitriana; Hepni, Hafiz Adhitama; Adiba, Thoriq Naufal; Saputri, Ginanjar Zukhruf; Supadmi, Woro; Abusri, Mila
Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang Vol. 9 No. 4 (2024): November 2024
Publisher : University of Merdeka Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26905/abdimas.v9i4.13826

Abstract

Purwosari Village has a high prevalence of non-communicable diseases (diabetes mellitus and hypertension). Health cadres in Purwosari Village have been formed, however they are still not optimal, especially the knowledge and skills of cadres in preventing non-communicable diseases for the elderly. This service activity aims to increase the capacity of Purwosari Village “Posyandu” cadres regarding NCDs to improve the quality of life of the elderly in the surrounding area.  The activity was carried out through a cadre school program with a lecture method for 2 offline sessions and continued with simulation for elderly posyandu cadres at the Purwosari Village, Kulonprogo. The activity is in partnership with Purwosari Village health cadres, the Girimulyo Public Health Promotion Team, and the Nasyiatul Aisyiyah Community of Kulonprogo. The activity was attended by a total of 67 cadres and 50 elderly posyandu cadres and 29 elderly people. The results of the activity showed an increase in the knowledge of cadres after education about non-communicable diseases prevention. The majority of cadres can understand the procedures for using and interpreting screening results. The elderly cadre school activities are effective in increasing the knowledge capacity regarding the prevention and monitoring of non-communicable diseases.
Co-Authors Adiba, Thoriq Naufal Ardhiana, Fiarriescha Marra Hepni, Hafiz Adhitama Kusrinanti, Nabillah Ainun Nuari, Yudha Rizky Saputri, Ginanjar Zukhruf Setyaningtyas, Padma Fitriana Tryadi, Oca Maharani Woro Supadmi Yudha Rizky Nuari Yuntari, Wahyu