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All Journal Pharmaciana: Jurnal Kefarmasian
Yudha Rizky Nuari
Faculty of Pharmacy, Universitas Ahmad Dahlan
Medicine & Pharmacology

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Self-nanoemulsifying drug delivery system (SNEDDS) of piroxicam: evaluation on anti-inflammantory activity in wistar rats Yudha Rizky Nuari; Iis Wahyuningsih; Sekar Prabawati
Pharmaciana Vol 11, No 2 (2021): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (860.084 KB) | DOI: 10.12928/pharmaciana.v11i2.20973

Abstract

Piroxicam is a non-steroidal anti-inflammatory drug (NSAID) that is commonly used for arthritis, gout, and other musculoskeletal disorders. Piroxicam is poorly soluble in water and according to the biopharmaceutical drug classification system (BCS) is classified as a Class II drug with good permeability but poor dissolution. The self-nanoemulsifying drug delivery system (SNEDDS) has been extensively employed to improve the dissolution and absorption of water-insoluble drugs within the gastrointestinal tract, leading to enhanced oral bioavailability and increased therapeutic effect of the loaded drugs. Therefore, the present study aims to evaluate the anti-inflammatory activity of piroxicam-loaded SNEDDS as compared to conventional piroxicam suspension that was observed in male Wistar strain rats. The SNEDDS was tailored from a mixture of oleic acid, tween 80, and propylene glycol. Twenty male Wistar strain rats (aged 2-3 months, weighed 150-250g) were selected and were divided equally into 4 different groups receiving 1% PVP, SNEDDS carrier, piroxicam suspension (1.8 mg/Kg BW), and SNEDDS piroxicam (1.8 mg/Kg BW). Acute inflammation was induced by a carrageenan-induced paw edema model where the carrageenan was injected sub plantar in the hind paw of the rats to induce edema. Several parameters including paw edema volume, AUC0-6, and percent anti-inflammatory effect, were measured to evaluate the anti-inflammatory activity experienced in each group. At the end of this study, the piroxicam SNEDDS group significantly demonstrated better protection from paw edema compared to the piroxicam suspension group (ρ<0.05), suggesting that SNEDDS may enhance the anti-inflammatory activity of piroxicam.
Publication trend of TMPRSS2 as SARS-CoV-2 receptor during the COVID-19 pandemic Lalu Muhammad Irham; Dyah Aryani Perwitasari; Yudha Rizky Nuari; Wirawan Adikusuma; Haafizah Dania; Rita Maliza; Made Ary Sarasmita; Rocky Cheung; Adi Wira Septama
Pharmaciana Vol 13, No 1 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (678.474 KB) | DOI: 10.12928/pharmaciana.v13i1.24052

Abstract

The Coronavirus Disease 2019 (COVID-19) pandemic has not yet been fully under public health control, which is still currently impacting a large number of people worldwide in 2023. Since the pandemic emerged, the growing number of publications related to TMPRSS2 as a SARS-CoV-2 receptor worldwide has increased rapidly with various findings and qualities. It is important to determine the trend of TMPRSS2 publication as no such studies currently exist that represent the publication trend related to this critical field of study. Here, we employed a bibliometric-based approach to evaluate the research trends of TMPRSS2 mechanistically as the SARS-CoV-2 receptor. We identified 1012 research documents published between 2020 and 2022 for this study. The most common document category was "Research Article" (646 articles, 63.84%) followed by "Review Article" (261 articles, 25.79%), and letters to editors (57 articles, 5.63%). Germany was the most cited country with a total of citations (9400 citations), followed by the USA (6409 citations) and China (1788 citations), respectively. In conclusion, given the impact of COVID-19, this study indicated TMPRSS2 as a SARS-CoV-2 receptor as a timely and highly relevant research topic.
Effects of Piper crocatum leaf extract-based ointments on bacteria associated with diabetic ulcers: an in vitro study Nuari, Yudha Rizky; Abusri, Mila; Yuntari, Wahyu; Tryadi, Oca Maharani; Ardhiana, Fiarriescha Marra
Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i2.28653

Abstract

Diabetic patients with poor blood glucose control are highly susceptible to developing secondary infections, which can lead to the development of prolonged diabetic ulcers. Therefore, a suitable medication that may effectively prevent the occurrence of secondary infections is crucial to shorten the closure of diabetic ulcers. Red betel leaf (Piper crocatum Ruiz & Pav) reportedly possesses antimicrobial activity due to the presence of flavonoids. This study aimed to evaluate the effect of ethanolic extract of red betel leaf (EERBL) ointments against the most prevalent bacteria associated with diabetic foot ulcers (DFU): Staphylococcus aureus and Pseudomonas aeruginosa. The EERBL was prepared by macerating powdered red betel leaf with 96% ethanol and was screened for the presence of flavonoids and the determination of total flavonoid content (TFC) by thin layer chromatography and UV-Vis spectrophotometry, respectively. This study examined three hydrophilic-based ointments containing 10%, 20%, and 30% EERBL, respectively, followed by characterization for pH, spreadability, stickiness, and viscosity. The EERBL ointments' effect on the bacteria was evaluated using the well-diffusion method by observing inhibition zone formation after 24-hour incubation. The results showed that varying the EERBL concentrations in the formulations led to different spreadability, stickiness and viscosity (p<0.05). Furthermore, all EERBL ointments demonstrated the formation of an inhibition zone on cultured media, indicating the presence of antimicrobial activity. The ointment with 30% EERBL had the largest diameter of the inhibition zone against both bacteria (p<0.05). The findings suggest enhanced antimicrobial activity was observed with an increase in the concentration of EERBL within the ointments.
Co-Authors Abusri, Mila Adi Wira Septama Ardhiana, Fiarriescha Marra Dyah Aryani Perwitasari Haafizah Dania Iis Wahyuningsih Lalu Muhammad Irham Made Ary Sarasmita Maliza, Rita Rocky Cheung Sekar Prabawati Tryadi, Oca Maharani Wirawan Adikusuma Yuntari, Wahyu