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All Journal Medika Trada Majority Science Journal
Astuti, Anna Kartika Yuli
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COMPARISON OF SARS-CoV ANTIBODY TITER LEVELS AGAINST ABO BLOOD TYPE, AGE, AND GENDER IN CONVALESCENT PLASMA DONATIONS Ariani, Resti; Puspita, Rina; Astuti, Anna Kartika Yuli; Lestari, Aulia Dewi; Dewi, Andriani Setiawan; Open, Maria Kurniati Manggina
MSJ : Majority Science Journal Vol. 2 No. 1 (2024): MSJ-February
Publisher : PT. Hafasy Dwi Nawasena

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61942/msj.v2i1.82

Abstract

An important requirement to become a convalescent plasma donor is a standardized SARS-CoV antibody titer. However, not all Covid-19 survivors pass the plasma donor selection due to low antibody titer. This research aims to determine the comparison of SARS-CoV antibody titer levels with blood type, age and gender of Covid-19 convalescent plasma donors at blood donation unit PMI Semarang City. This study is an analytical observational study with a cross sectional design, using 300 data on convalescent plasma donors. The sampling technique used was purposive sampling. Differences in SARS-CoV antibody titer levels based on blood type, age, and gender were tested using SPSS 25. Donors involved in this study were divided based on the conversion of convalescent plasma titer levels, namely 1:80 (37%), 1:160 (4%), 1:250 (10.3%) and 1:640 (48.7%). Based on blood type data, most convalescent plasma donors have blood type O (42%) with the highest titer levels in the 1:640 category (48.7%). The highest mean titer level was found in blood group B which was 382.09. The results of the Kruskal-Wallis test showed no significant difference in titer levels by blood group, p=0.622 (>0.05). In the parameter of donor age, SARS-CoV antibody titer levels also showed no significant difference in donor age, both adolescent, adult and elderly donors with a value of p=0.598 (p>0.05). In line with these results, the chi square test of differences in antibody titres based on gender also showed no significant difference, p value=0.127 (p>0.05). High and low antibody titres of convalescent plasma donors are not determined by blood type, age and gender of the donor.
Pengaruh Durasi Penyimpanan Terhadap Kualitas Packed Red Cell Di UDD PMI Kota Semarang Subekti; Hari Wijaya, Galih; Astuti, Anna Kartika Yuli; Widoyono
MEDIKA TRADA Vol 5 No 1 (2024): MEDIKA TRADA (JTEMP) Vol 5 No 1 (2024)
Publisher : LPPM POLBITRADA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59485/jtemp.v5i1.64

Abstract

Packed Red Cell (PRC) storage affects the stability of erythrocytes, this condition can pose a risk of decreased hemoglobin diffusion into tissues due to the storage process. The role of PRC to increase hemoglobin in patients is inseparable from the fact that the product experiences a decrease in quality during storage. This study aims to determine the effect of Packed Red Cell (PRC) storage duration for 21, 28, 35 days on the quality of PRC carried out at the UDD PMI Semarang City. The research method was Quasi Experiment study, with a modification of Time Series Design using the Quota sampling technique. PRC research samples were taken at the UDD PMI Semarang City in July-September 2023 with a total of 24 bags. The independent variable is the duration of PRC storage, the dependent variable is the quality of PRC. Based on the results of this study, it shows that hemoglobin (Hb) and hematocrit (Ht) increased from  day 21 to day 35 but not significantly (P> 0.05), while hemolysis showed an increase from day 21 to day 35  significantly (P <0.05) but the value is still within normal limits. Correlation value between Hb and PRC storage duration; r = 0.948, Ht with PRC storage duration; r = 0.202, hemolysis with PRC storage duration; r = 0.000. The conclusion of this study is that there is no significant effect on hemoglobin and hematocrit levels of PRC products with storage days 21, 28, and 35, and there is a significant effect on hemolysis levels but still within normal limits according to the requirements of the Minister of Health. Suggestions for further research with a better number of samples, types of examinations and designs to determine the standards and storage time limits for PRC. Keywords: Quality, Packed Red Cell, Storage
Co-Authors Ariani, Resti Dewi, Andriani Setiawan Hari Wijaya, Galih Lestari, Aulia Dewi Open, Maria Kurniati Manggina Puspita, Rina Subekti Widoyono