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All Journal Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia
Fatril, Ayu Eka
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Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Public Health

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Kajian Komprehensif Pichia kudriavzevii: Epidemiologi, Biologi dan Manifestasi Klinis sebagai Parasit pada Manusia Fatril, Ayu Eka; Adawiyah, Robiatul
Majalah Kedokteran Indonesia Vol 75 No 3 (2025): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.75.3-2025-1865

Abstract

Pichia kudriavzevii previously known as Candida krusei, is a non-conventional yeast commonly found in the environment and widely utilized in the fermentation industry. Besides its industrial benefits, P. kudriavzevii also acts as an opportunistic pathogen that can cause severe infections, particularly in immunocompromised individuals. This study is a literature review analyzing the epidemiology, biology, pathogenicity, immune response and clinical manifestations associated with P. kudriavzevii. Relevant literature was collated from databases such as PubMed, Scopus, and Google Scholar, selected based on article relevance and quality. The review findings indicate that P. kudriavzevii is among the five most common Candida species that infect humans, particularly in patients with compromised immune systems, cancer, hematologic malignancies, diabetes mellitus, and those undergoing prolonged antibiotic or corticosteroid therapy. Biologically, P. kudriavzevii exhibits high tolerance to extreme environmental conditions, possesses biofilm-forming capabilities and demonstrates intrinsic resistance to fluconazole. Infections caused by P. kudriavzevii, reffered to as candidiasis krusei, range from mucocutaneous infections (oral/oropharyngeal candidiasis, vaginal candidiasis, and cutaneous candidiasis) to invasive candidiasis which can be life-threatening. The increasing incidence of P. kudriavzevii infections and its antifungal resistance demand greater attention in developing effective diagnostic and therapeutic strategies. Further studies are essential to elucidate its resistance mechanisms and explore alternative therapeutic approaches for improving clinical management.
Pola Kepekaan Candida krusei Isolat Jakarta terhadap Flukonazol Fatril, Ayu Eka; Adawiyah, Robiatul; Wahyuningsih, Retno
Majalah Kedokteran Indonesia Vol 70 No 6 (2020): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.70.6-2020-230

Abstract

Introduction: Candida krusei inhabit the human body as saprophyte but can turn into pathogen and causes mycosis. Candida krusei usually primarily resistant to fluconazole but laboratory data in Jakarta has different results. We found fluconazole-susceptible isolates which encouraged us to do prospective studies using the different isolates of C. krusei.Method: The study was conducted in 2019-2020 in the Laboratory of Parasitology, Faculty of Medicine, Universitas Indonesia. The total of 15 C. krusei isolates were tested by disc diffusion method. Before being tested, the isolates were refreshed and purified to obtain a single colony. Result: The isolates used, derived from many clinical samples i.e. stool, sputum, broncho-alveolar lavage (LAB) and one isolate isolated from lung abscess. The result of susceptibility test showed nine fluconazole-resistant isolates, one intermediate isolate and five fluconazole-susceptible isolates. Conclusion: It can be concluded, in vitro, some Candida krusei isolates in Jakarta are susceptible to fluconazole.
Co-Authors Retno Wahyuningsih Robiatul Adawiyah