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All Journal eJournal Kedokteran Indonesia IJRETINA - International Journal of Retina Oftalmologi: Jurnal Kesehatan Mata Indonesia
Nilawati, Enny
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Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Library & Information Science Medicine & Pharmacology Neuroscience Nursing Public Health

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PSEUDOMONAS AERUGINOSA-INDUCED ACUTE EXOGENOUS ENDOPHTHALMITIS POST-CATARACT SURGERY Akbar, Muhammad Khalil; Nilawati, Enny
Oftalmologi : Jurnal Kesehatan Mata Indonesia Vol 5 No 2 (2023): Jurnal Oftalmologi Vol 5 No 2 2023
Publisher : Pusat Mata Nasional Rumah Sakit Mata Cicendo Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/ojkmi.v5i2.51

Abstract

Introduction: The Endophthalmitis Vitrectomy Study revealed that only a small percentage of endophthalmitis cases, specifically 4.1%, were caused by Gram-negative organisms, and the most frequent of these was Pseudomonas aeruginosa. Moreover, poor visual outcomes were consistently linked to this bacterium. Objective: To provide knowledge regarding Pseudomonas aeruginosa as a cause of exogenous endophthalmitis and its management. Case Illustration: A 65-year-old male was admitted to the Emergency Department due to pain and blurred vision in his left eye. After cataract surgery, three days prior, these symptoms had been present for four days. The patient had conjunctival redness, corneal edema, posterior synechia of the iris, and very low visual acuity in the affected eye. A B-mode ocular ultrasonography revealed a considerable vitreous opacity and an aberrant echo in the left eye, suggesting endophthalmitis in the patient. The patient underwent emergency surgery immediately, including Pars plana vitrectomy (PPV), Silicon oil, IOL extraction, and intravitreal antibiotics injection. Moreover, Pseudomonas aeruginosa was found in the vitreous by a smear test and culture process. On the first day after the surgery, the patient's vision improved to light perception but with incorrect projection. A Fundus exam showed an attached retina with silicon oil and no macular edema. After one month, the patient's visual acuity improved to 2/60. Conclusions: Identifying the causative organisms in infectious endophthalmitis is critical in determining treatment and visual results. Pars Plana Vitrectomy (PPV) followed by intravitreal injection of antibiotics as the "gold standard" treatment for acute postoperative endophthalmitis.
Clinical Characteristics of Uveitis Patients at Dr. Zainoel Abidin General Hospital Aceh Samira, Cut Putri; Nilawati, Enny; Islami, Dian; Rosdiana, Eka
Oftalmologi : Jurnal Kesehatan Mata Indonesia Vol 6 No 3 (2024): Oftalmologi: Jurnal Kesehatan Mata Indonesia
Publisher : Pusat Mata Nasional Rumah Sakit Mata Cicendo Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/ojkmi.v6i3.78

Abstract

Introduction: Uveitis is a sight-threatening condition characterized by inflammation in the uveal tract. In Aceh, data on the incidence of uveitis remains unavailable despite numerous reported cases. This study aims to analyze uveitis characteristics in Aceh, Indonesia, and provide information regarding the causes and patterns of inflammation to guide diagnostic and therapeutic approaches. Methods: A retrospective descriptive study was conducted using medical records from Dr. Zainoel Abidin Hospital from uveitis patients between January 2023 and August 2024. Data were analyzed for demographics, clinical presentation, etiology, management, and complications. Results: There were 60 patients with 92 eyes affected with the mean age between 20-44 years. Bilateral involvement occurred in 53.3% of cases with the common chief complaint being blurry vision (53.3%). Tuberculosis was the leading infectious cause (41.3%), while 30.4% of cases were idiopathic. Complications, including cataracts (52%) and glaucoma (12.6%) were prevalent. Conclusion: This study highlights the pattern of uveitis in Aceh, with tuberculosis as the leading cause of infection. Further research into strategies is required to expedite diagnosis and treatment by following local infection trends.
Effect of Hydroxychloroquine Therapy on Hematology and Ocular Manifestations of Systemic Lupus Erythematosus Patients Muhsin, Muhsin; Sylvawani, Mahriani; Abdullah, Vera; Nilawati, Enny; Riswan, Muhammad; Abdullah, Abdullah; Syukri, Maimun
eJournal Kedokteran Indonesia Vol. 13 No. 3 (2025): Vol. 13 No. 3 - Desember 2025
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.13.1181.1

Abstract

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that mainly affects women and has various clinical manifestations involving multiple organs. The use of hydroxychloroquine (HCQ) provides some advantages. This study aimed to analyze hematological and ocular effects following short-term HCQ administration in SLE patients. A cross-sectional study was conducted from April to July 2022 at Zainoel Abidin Hospital, Banda Aceh, Indonesia, involving 23 female SLE patients. Blood laboratory parameters were assessed, and an ophthalmologist performed ocular examinations. The study showed an average hemoglobin of 11.6 g/dL. Other blood laboratory results were within normal limits. The mean duration of SLE diagnosis and HCQ use was 21.0 months and 9.7 months, respectively. There was no correlation between HCQ use duration and hematological parameters (hemoglobin, leukocytes, and thrombocytes; p values 0.38, 0.14, and 0.62, respectively). This study showed that only one SLE patient taking HCQ for less than five years had ocular problems. The prevalence of ocular and hematological effects in SLE patients treated with HCQ for less than five years is minimal.
ENDOPHTHALMITIS IN ACEH: ANALYSIS OF MICROBIAL SPECTRUM AND ANTIBIOTIC RESISTANCE Samira, Cut Putri; Nilawati, Enny; Zaini, Lia Meuthia; Islami, Dian; Mulya, Putri Nabillah
International Journal of Retina Vol 9 No 1 (2026): International Journal of Retina (IJRetina) - INAVRS
Publisher : Indonesian Vitreoretinal Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35479/ijretina.2026.vol009.iss001.344

Abstract

Introduction: Endophthalmitis is a rare but vision-threatening intraocular infection that requires prompt and appropriate antimicrobial therapy. The microbial spectrum and antibiotic resistance patterns vary by region, yet data from Aceh, Indonesia, are limited. This study aimed to analyze the microbial profile and antibiotic susceptibility patterns of endophthalmitis cases treated at a tertiary healthcare center in Aceh. Methods: A retrospective descriptive study was conducted using medical records of patients diagnosed with endophthalmitis at dr. Zainoel Abidin General Hospital, Banda Aceh, from January 2021 to December 2024. Data collected included demographics, predisposing factors, etiological classification, microbiological culture results, and antibiotic susceptibility profiles. Microbiological identification and susceptibility testing were performed using standard culture methods and the VITEK2 Compact system. Result: A total of 111 eyes with unilateral endophthalmitis were included. Exogenous endophthalmitis predominated (95.5%), with post–cataract surgery (36.0%), traumatic (29.7%), and keratitis-related (27.1%) cases being most common. The mean patient age was 52.7 ± 18.5 years, with male predominance (63%). Bacterial isolates were identified in 26 eyes (23.5%), with Gram-negative organisms accounting for 65.4%. Pseudomonas aeruginosa was the most frequently isolated pathogen (58.8%). Gentamicin showed the highest overall susceptibility (75.0%), while vancomycin demonstrated complete sensitivity against Gram-positive isolates. Conclusion: Endophthalmitis in Aceh is predominantly exogenous and commonly caused by Gram-negative bacteria, particularly Pseudomonas aeruginosa. Gentamicin demonstrated the highest in vitro activity, while vancomycin and ceftazidime remain key components of empirical intravitreal therapy to ensure broad antimicrobial coverage. These findings provide important local microbiological data to support evidence-based management of endophthalmitis.
Co-Authors Abdullah Abdullah Abdullah, Vera Akbar, Muhammad Khalil Islami, Dian Lia Meuthia Zaini, Lia Meuthia Maimun Syukri, Maimun Muhsin Muhsin Mulya, Putri Nabillah Riswan, Muhammad Rosdiana, Eka Samira, Cut Putri Sylvawani, Mahriani