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All Journal Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences Narra J The Journal of Society Medicine (JSOCMED) Narra X Indonesian Journal of Case Reports Trends in Infection and Global Health
Maimun Syukri, Maimun
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Religion Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences

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Relationship between Physical Activities, Stress and Eating Patterns with the Risk of Hipertension in Women in Baiturrahman Community Health Centers Banda Aceh Sari, Etika; Yusni, Yusni; Usman, Said; Syukri, Maimun; Yusuf, Hanifah
Budapest International Research and Critics Institute (BIRCI-Journal): Humanities and Social Sciences Vol 3, No 3 (2020): Budapest International Research and Critics Institute August
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birci.v3i3.1142

Abstract

The pattern of disease events at this time has experienced a change marked by changes in disease and death that were originally dominated by infectious diseases switch to non-communicable diseases. In the 2018 Riskesdas results the prevalence of hypertension in Aceh increased compared to 2013. Purpose: to find out the factors associated with the incidence of hypertension in women at the Baiturrahman Health Center in Banda Aceh City. Research Methods: This research is a type of quantitative research with cross-sectional study design conducted on 124 samples. Sampling was carried out using the Accidental Sampling technique. Data analysis uses univariate, bivariate and multivariate. Statistical analysis using chi-square and logistic regression. Results: The results showed that there was a significant relationship between family history (p-value = 0.007, OR = 2.8), food consumption patterns (p-value = 0.025, OR = 2.5), obesity status (p-value = 0.046, OR = 2.2), Physical activity (p-value = 0.012, OR = 3.2) and Stress (p-value = 0.017, OR = 2.9) with the incidence of hypertension in women. Multivariate analysis results indicate that family history is a dominant factor in the incidence of hypertension (OR = 4.7). Conclusion: Family history, food consumption patterns, obesity, physical activity and stress are related to the incidence of hypertension and the most dominant factor in the incidence of hypertension in women in the working area of the Baiturrahman Health Center in Banda City is family history of hypertension.
Role of Glucagon in The Metabolic Response: Review Tona, Azwar Iwan; Syukri, Maimun
Journal of Society Medicine Vol. 2 No. 2 (2023): February
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v2i2.62

Abstract

Historically, glucagon is the counter-regulatory hormone of insulin. Glucagon secretion is induced by fasting conditions or hypoglycaemia to increase glucose levels. Glucagon is the dominant product of alpha cells in the islet and was first identified in 1923 during an attempt to purify insulin, where it was identified as a contaminant hyperglycaemia factor. Further research determined that the hyperglycaemic action of glucagon is mediated by increased hepatic glycogenolysis and gluconeogenesis to increase endogenous glucose production. Insulin and glucagon as opposing hormones work together for glycaemic control. Diabetic hyperglycaemia is caused by increased impaired insulin action and inappropriately elevated glucagon levels. This review summarizes an important function of glucagon is its role as a regulator of glucose homeostasis. Increased plasma glucagon levels lead to increased hepatic glucose production. The balance between insulin and glucagon is responsible for maintaining euglycaemia conditions. In conditions of hypoglycaemia, increased glucagon secretion leads to increased hepatic glucose production through a number of cellular mechanisms including suppression of glycogenesis and glycolysis and stimulation of glycogenolysis and gluconeogenesis
Effects of SGLT2 inhibitor administration on blood glucose level and body weight in type 1 diabetes rat model Syukri, Maimun; Zaini, Lia M.; Kartasasmita, Arief S.; Gondhowiardjo, Tjahjono D.; Lesmana, Ronny
Narra J Vol. 3 No. 2 (2023): August 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i2.194

Abstract

The prevalence of diabetes worldwide is increasing and 629 million people are projected to have diabetes by 2045, and the most significant burden of the disease being concentrated in low- and middle-income countries (LMICs). Type 2 diabetes is mainly treated with insulin adjunctive therapies such as metformin to improve insulin sensitivity and sodium-glucose co-transporter 2 (SGLT2) inhibitors to lower blood glucose levels. However, there was limited study on the application of SGLT2 inhibitors on type 1 diabetes, particularly empagliflozin. Therefore, this study aimed to determine the effect of SGLT2 inhibitors on blood glucose levels and body weights in a rat model of type 1 diabetes. To mimic type 1 diabetes, the rats were injected with streptozotocin 60 mg intra-peritoneally. Twenty-four rat models were randomly divided into four groups: normal rat group (negative control), untreated diabetic rat group (positive control), type 1 diabetic rats treated with metformin, and type 1 diabetic rats treated with empagliflozin. Blood glucose levels and body weight were recorded before and after induced with streptozotocin and on weeks 4, 6, 8 and 10 of the treatment with anti-diabetic drugs. This study found that the blood glucose levels before and after treatment significantly decreased in all groups (p<0.05), except in the negative control group. Similar results were observed in body weight of the rats, which all groups experienced weight loss, except the negative control. These results suggested that apart from being used in type 2 diabetes, SGLT2 inhibitors may also be used as a treatment for type 1 diabetes.
Treatment acceptance and its associated determinants in cancer patients: A systematic review Novirianthy, Rima; Syukri, Maimun; Gondhowiardjo, Soehartati; Suhanda, Rachmad; Mawarpury, Marty; Pranata, Agung; Renaldi, Teuku
Narra J Vol. 3 No. 3 (2023): December 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i3.197

Abstract

Treatment recommendations for cancer patients are carried out according to clinical assessment, type and stage of cancer and treatment guidelines. However, many patients do not accept the recommendations. This raises obstacles in managing of cancers, which not only affects the patients, but also the family and people around the patients. This problem could increase morbidity, mortality and recurrence rate, which might result in lower quality of life. Since this condition is a complex problem, there is necessity to explore and determine various determinants from different levels. The aim of this systematic  review was to explore the acceptances of cancer treatments among cancer patients and its associated determinants. Articles published from 2010 to 2023 were searched in four databases: ScienceDirect, Medline, Google Scholar and PubMed. Articles written in English and focussing on three main cancer treatments (surgery, chemotherapy and radiotherapy) were eligible.  A narrative approach was used and the data were analysed into selected themes. Data suggest that several factors influence patient acceptance for cancer therapy including sociodemographic, economic and spiritual cultural backgrounds; patient knowledge and perceptions; community support, as well as policy and availability of health facilities.  The determinants consist of individual, interpersonal, institutional, community and public policy level and interaction between levels are contributing to cancer treatment acceptance. In conclusion, cancer treatment acceptance remains a problem in particular in low middle income countries. In addition, the data on radiotherapy referral acceptance were limited and needed further study.
Quality of life and its predictors among people living with HIV in Muslim majority region: A cross-sectional study in Aceh Hasan, Maryatun; Jamil, Kurnia F.; Darmawi, Darmawi; Syukri, Maimun; Liansyah, Tita M.; Beočanin, Anđelija; Erianza, Dava
Narra J Vol. 3 No. 2 (2023): August 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i2.202

Abstract

Human immunodeficiency virus (HIV) and acquired immune deficiency syndrome (AIDS) remain significant global health challenges addressed by countries worldwide. The advent of antiretroviral therapy (ARV) has significantly reduced morbidity and mortality of people living with HIV (PLHIV), transforming HIV/AIDS from a fatal disease to a manageable chronic disease. However, the increasing number of elderly individuals with HIV who experience early frailty syndrome presents new challenges and potential for diminished quality of life. The aim of this study was to assess the quality of life and to identify its significant predictors in PLHIV patients who have received ARV therapy in Banda Aceh, a Muslim-majority region in Indonesia. A cross-sectional study was conducted on all PLHIV who received ARV therapy at the voluntary counseling and testing (VCT) polyclinic at Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia between January and February 2023. The WHOQOL-HIV BREF instrument, a multi-dimensional tool developed by the World Health Organization (WHO), was used to assess the quality of life of the PLHIV, and potential predictors were assessed. The Chi-squared test was used to determine the predictors associated with the quality of patient’s lives. Our data indicated that the majority of PLHIV were male (88%), 26–35 years old (78%), employed (92%), and unmarried (54%). Poor quality of life was dominant for the physical health (100%) and social relationships (76%) domains. In contrast, good quality of life was observed in aspects of independence, psychology, and spirituality, all reporting 100% results. Significant associations were found between married status (p=0.004) and medication adherence (p<0.001) with higher quality of life among PLHIV. In conclusion, married PLHIVs that received support from their partners regarding adherence to therapy exhibited a better quality of life. These results underscore the significance of sustained support systems and adherence strategies to enhance PLHIV's quality of life.
Risk factors of MDR-TB and impacts of COVID-19 pandemic on escalating of MDR-TB incidence in lower-middle-income countries: A scoping review Ichsan, Ichsan; Redwood-Campbell, Lynda; Mahmud , Nissa N.; Dimiati, Herlina; Yani, Muhammad; Mudatsir , Mudatsir; Syukri, Maimun
Narra J Vol. 3 No. 2 (2023): August 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i2.220

Abstract

The coronavirus disease 2019 (COVID-19) pandemic is affecting tuberculosis (TB) treatment in many ways that might lead to increasing the prevalence of multi-drugs-resistance tuberculosis (MDR-TB), especially in lower-middle-income-countries (LMICs). This scoping review aimed to identify the risk factors of MDR-TB and to determine the impacts of the COVID-19 pandemic on MDR-TB prevalence in LMICs. This study was reported according to the preferred reporting items for systematic reviews and meta-analyses extension for scoping reviews (PRISMA-ScR) guideline. The relevant keywords were used to search studies in three databases (PubMed, ScienceDirect and SpringerLink) to identify the related articles. The English-written articles published from January 2012 to December 2022 that explored risk factors or causes of MDR-TB in LMICs were included. Out of 1,542 identified articles, 17 retrospective, prospective, case-control and cross-sectional studies from ten LMICs met were included in this scoping review. Twenty-one risk factors were discovered, with prior TB treatment (relapsed cases), diabetes, living area, living condition, smoking and low socioeconomic status were the main factors in developing MDR-TB during COVID-19 pandemic. The pandemic increased the MDR-TB prevalence through drug resistance transmission inside households, the distance between home and healthcare facilities and low socioeconomic status. This scoping review demonstrates how the COVID-19 pandemic has affected the rising incidence of MDR-TB in LMICs.
Association between caregiver burden in family and hemodialysis compliance of chronic kidney disease patients in Aceh, Indonesia Al-Muchtari, Teuku AZ.; Syukri, Maimun; Yusni, Yusni
Narra J Vol. 3 No. 3 (2023): December 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i3.255

Abstract

Patient compliance toward undergoing treatment determines its success rate. Unfortunately, the compliance among hemodialysis patients is concerning. Supports from family has been suggested influence the patient compliance, especially from a family member who acts as a caregiver. The aim of this study was to determine the association between the level of caregiver burden and compliance in hemodialysis patients. A cross-sectional study was conducted at Dialysis Installation at Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia. The study sample was family members who accompanied hemodialysis patients. The minimal number of patients was determined of which 67 respondents were required and therefore recruited. Caregiver burden was collected using direct interview using Caregiver Burden Assessment questionnaire. The results revealed that twenty-four respondents (35.8%) had moderate caregiver burden, while there were only nine respondents (13.4%) had very low caregiver burden. The majority of the hemodialysis patients were non-compliant (n=38, 56.7%). A Chi-squared test indicated a significant association between the status of caregiver burden and the patient compliance to hemodialysis (p=0.011). These findings stress the importance of addressing caregiver burden in ensuring the compliance of patients receiving hemodialysis.
Interpretable Machine Learning for Chronic Kidney Disease Diagnosis: A Gaussian Processes Approach Noviandy, Teuku Rizky; Idroes, Ghifari Maulana; Syukri, Maimun; Idroes, Rinaldi
Indonesian Journal of Case Reports Vol. 2 No. 1 (2024): June 2024
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/ijcr.v2i1.204

Abstract

Chronic Kidney Disease (CKD) is a global health issue impacting over 800 million people, characterized by a gradual loss of kidney function leading to severe complications. Traditional diagnostic methods, relying on laboratory tests and clinical assessments, have limitations in sensitivity and are prone to human error, particularly in the early stages of CKD. Recent advances in machine learning (ML) offer promising tools for disease diagnosis, but a lack of interpretability often hinders their adoption in clinical practice. Gaussian Processes (GP) provide a flexible ML model capable of delivering predictions and uncertainty estimates, essential for high-stakes medical applications. However, the integration of GP with interpretable methods remains underexplored. We developed an interpretable CKD classification model to address this knowledge gap by combining GP with Shapley Additive Explanations (SHAP). We assessed the model's performance using three GP kernels (Radial Basis Function, Matern, and Rational Quadratic). The results show that the Rational Quadratic kernel outperforms the other kernels, achieving an accuracy of 98.75%, precision of 100%, sensitivity of 97.87%, specificity of 100%, and an F1-score of 98.51%. SHAP values indicate that haemoglobin and specific gravity are the most influential features. The results demonstrate that the Rational Quadratic kernel enhances predictive accuracy and provides robust uncertainty estimates and interpretable explanations. This combination of accuracy and interpretability supports clinicians in making informed decisions and improving patient management and outcomes in CKD. Our study connects advanced ML techniques with practical medical applications, leading to more effective and reliable ML-driven healthcare solutions.
Comparative study of anti-SARS-CoV-2 receptor-binding domain total antibody titer before and after heterologous booster with mRNA-based COVID-19 vaccine Kamil, Qatrunnada; Putri, Widia; Ayulinda, Arianisah P.; Maelani, Imelda; Anwar, Samsul; Ichsan, Ichsan; Pranata, Agung; Mudatsir, Mudatsir; Syukri, Maimun; Rizal, Samsul; Kurniawan, Rudi; Sofyan, Sarwo E.; Harapan, Harapan
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.788

Abstract

The waning immunity following the COVID-19 vaccination become a significant concern and the immunological dynamics of vaccine-induced antibodies after vaccination need to be explored. The aim of this study was to compare anti-SARS-CoV-2 receptor-binding domain (RBD) antibody levels before and after a booster dose with heterologous COVID-19 vaccine and to identify factors influencing the levels after receiving the booster dose. A cross-sectional study was conducted in which individuals who received primary doses of CoronaVac and a booster dose with an mRNA-based vaccine were recruited using a purposive sampling technique. The titers of anti-SARS-CoV-2 RBD antibodies were measured using an enzyme-linked immunosorbent assay (ELISA), and plausible associated factors were collected using a questionnaire-assisted face-to-face interview. The Wilcoxon test was used to compare the titers before and after the booster dose, while the Kruskal-Wallis and Mann-Whitney tests, followed by multivariate linear regression, were used to assess the factors associated with RBD total antibody titers. The results showed that there was a significant increase of anti-SARS-CoV-2 RBD total antibody titers before and after receiving the booster dose (1,558.7 BAU/mL vs 140.6 BAU/mL, p<0.001). The analysis revealed that age (p=0.555), sex (p=0.254), type of vaccine (p=0.914), presence of hypertension (p=0.541), diabetes (p=0.975), chronic obstructive pulmonary disease (COPD, p=0.620), and gout (p=0.364) were not associated with anti-SARS-CoV-2 RBD total antibody titers. However, the titers of anti-SARS-CoV-2 RBD total antibody were significantly different between those with and without hyperlipidemia (p=0.021). This study suggests that a booster dose with a heterologous COVID-19 vaccine could significantly enhance immune responses against COVID-19, and therefore, this strategy may be recommended as part of preventive measures to strengthen immunity against COVID-19.
The role of local wisdom in preventing adolescent risk behaviors based on safe communities safe schools in Banda Aceh Renaldi, Teuku; Syukri, Maimun; Oktari, Rina S.; Nurjannah, Nurjannah
Trends in Infection and Global Health Vol 4, No 2 (2024): December 2024
Publisher : School of Medicine, Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/tigh.v4i2.40836

Abstract

Adolescent risk behavior is a public health problem that occurs globally. The presence of the digital era is characterized by increased access to online content and contributes to the rise of risk behavior among teenagers. The Center for Study and Prevention of Violence (CSPV) at the University of Colorado, United States has developed the concept of Safe Communities Safe Schools (SCSS) as a model for preventing adolescent risk behavior in Colorado. The development of the current situation in Indonesia, especially in Banda Aceh, has given rise to the need for an equivalent concept in Banda Aceh. Adaptation and implementation of the SCSS concept from Colorado to Banda Aceh require adjustments that accommodate cultural components, including local wisdom. The aim of this study was to examine the role of local wisdom in supporting the implementation of SCSS as prevention of risk behavior among adolescents in Banda Aceh. This research uses a qualitative design with a grounded theory approach. Data collection was carried out through in-depth interviews with key informants, namely Acehnese special institutions which officially represent expertise in local wisdom in the City of Banda Aceh. These institutions are: the Regional Education Council (MPD), Aceh Tradition Council (MAA), and Banda Aceh City Ulama Council (MPU). Data analysis was carried out using applied thematic analysis. This research identifies local wisdom sourced from Islamic law, which is a cultural characteristic of the Acehnese people and has the potential to play a role in supporting the implementation of SCSS. The local wisdoms are: education in Islamic values, akhlakul karimah, special relationships between teachers and parents of students (takzim keu guree), and traditional gampong governance. The Banda Aceh City Government has implemented local wisdom education on Islamic values, including akhlakul karimah through the diniyah program in schools. Traditional gampong governance can play its role through two mechanisms: revitalizing the local wisdom of takzim keu guree through community development targeting students' parents and reviving the local wisdom of akhlakul karimah in the community targeting students and families. Local wisdom implemented through the diniyah program is in line with the implementation of SCSS in schools, and local wisdom of traditional gampong governance and takzim keu guree can be a form of support for SCSS from the community. This support can be realized considering that Sharia law and traditional gampong governance have received legal regulation for their implementation in the City of Banda Aceh. Banda Aceh's local wisdom originating from Islamic law can play a role in supporting the implementation of SCSS as a prevention of risk behavior among teenagers in Banda Aceh. This research recommends utilizing local wisdom of Sharia law and gampong governance through regulatory mechanisms and cross-sectoral cooperation.
Co-Authors Agung Pranata Al-Gunaid, Seba Al-Muchtari, Teuku AZ. Arief S. Kartasasmita Ayulinda, Arianisah P. Beočanin, Anđelija Darmawi . Erianza, Dava Hanifah Yusuf Harapan Harapan Hasan, Maryatun Herlina Dimiati, Herlina Ichsan Ichsan Idroes, Ghifari Maulana Iwan Tona, Azwar Jayawarsa, A.A. Ketut Kamil, Qatrunnada Kurnia F. Jamil Kurniawan , Ferry D. Liansyah, Tita M. Maelani, Imelda Mahmud , Nissa N. Marty Mawarpury Mudatsir , Mudatsir Mudatsir Mudatsir Muhammad Yani, Muhammad Nurjannah Nurjannah Oktari, Rina S. Putri, Widia Rachmad Suhanda Redwood-Campbell, Lynda Renaldi, Teuku Rima Novirianthy Rinaldi Idroes Ronny Lesmana Rudi Kurniawan Samsul Anwar Sari, Etika Soehartati Gondhowiardjo Sofyan, Sarwo E. Syamsul Rizal Teuku Rizky Noviandy Tjahjono D. Gondhowiardjo Tona, Azwar Iwan Usman, Said Yusni Yusni Yusni Yusni Zaini, Lia M.