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Riensya, Bayu Aulia
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Health Professions Medicine & Pharmacology

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Risk Factors for EGFR (Epidermal Growth Factor Receptor) Gene Mutations in Lung Adenocarcinoma Patients at Arifin Achmad Hospital, Riau Province Riensya, Bayu Aulia; Munir, Sri Melati; Wijaya, Dewi
Jurnal Respirologi Indonesia Vol 44, No 3 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i3.484

Abstract

Background: Lung cancer is the first cause of oncological death worldwide. Guidelines made by various cancer associations, including PDPI-IASTO, regarding NSCLC recommend that all advanced stages of NSCLC undergo target genetic testing, such as EGFR mutations. The incidence of EGFR mutations in Asian populations is quite high.Methods: This was a retrospective observational analytic study with a cross-sectional study design.Results: The most unmodifiable risk factors were age ≥45 years (81.4%), male sex (70.6%), location of lung cancer on the right (52.9%), cancer size of ≥5 cm (100%), M1a metastases (57.8%), and no family history of malignancy (97.1%). The smoking status (ex-smoker) (P=0.022; OR=4.3; 95% CI=1.24-15.57), sex (male) (P=0.007; OR=3.409; 95% CI=1.406-8.268), and metastatic status (M1a) (P=0.025; OR=0.203; 95% CI=0.05-0.821) were the dominant risk factors that affected the incidence of EGFR mutations in patients with lung adenocarcinoma at Arifin Achmad Hospital.Conclusion: Male, ex-smokers, and metastatic status (M1a) were the dominant risk factors for the incidence of EGFR mutations in lung adenocarcinoma patients at Arifin Achmad Hospital. 
Risk Factors for EGFR (Epidermal Growth Factor Receptor) Gene Mutations in Lung Adenocarcinoma Patients at Arifin Achmad Hospital, Riau Province Riensya, Bayu Aulia; Munir, Sri Melati; Wijaya, Dewi
Jurnal Respirologi Indonesia Vol 44 No 3 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i3.484

Abstract

Background: Lung cancer is the first cause of oncological death worldwide. Guidelines made by various cancer associations, including PDPI-IASTO, regarding NSCLC recommend that all advanced stages of NSCLC undergo target genetic testing, such as EGFR mutations. The incidence of EGFR mutations in Asian populations is quite high.Methods: This was a retrospective observational analytic study with a cross-sectional study design.Results: The most unmodifiable risk factors were age ≥45 years (81.4%), male sex (70.6%), location of lung cancer on the right (52.9%), cancer size of ≥5 cm (100%), M1a metastases (57.8%), and no family history of malignancy (97.1%). The smoking status (ex-smoker) (P=0.022; OR=4.3; 95% CI=1.24-15.57), sex (male) (P=0.007; OR=3.409; 95% CI=1.406-8.268), and metastatic status (M1a) (P=0.025; OR=0.203; 95% CI=0.05-0.821) were the dominant risk factors that affected the incidence of EGFR mutations in patients with lung adenocarcinoma at Arifin Achmad Hospital.Conclusion: Male, ex-smokers, and metastatic status (M1a) were the dominant risk factors for the incidence of EGFR mutations in lung adenocarcinoma patients at Arifin Achmad Hospital. 
Co-Authors Sri Melati Munir Wijaya, Dewi