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Risk Factors for EGFR (Epidermal Growth Factor Receptor) Gene Mutations in Lung Adenocarcinoma Patients at Arifin Achmad Hospital, Riau Province Riensya, Bayu Aulia; Munir, Sri Melati; Wijaya, Dewi
Jurnal Respirologi Indonesia Vol 44, No 3 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i3.484

Background: Lung cancer is the first cause of oncological death worldwide. Guidelines made by various cancer associations, including PDPI-IASTO, regarding NSCLC recommend that all advanced stages of NSCLC undergo target genetic testing, such as EGFR mutations. The incidence of EGFR mutations in Asian populations is quite high.Methods: This was a retrospective observational analytic study with a cross-sectional study design.Results: The most unmodifiable risk factors were age ≥45 years (81.4%), male sex (70.6%), location of lung cancer on the right (52.9%), cancer size of ≥5 cm (100%), M1a metastases (57.8%), and no family history of malignancy (97.1%). The smoking status (ex-smoker) (P=0.022; OR=4.3; 95% CI=1.24-15.57), sex (male) (P=0.007; OR=3.409; 95% CI=1.406-8.268), and metastatic status (M1a) (P=0.025; OR=0.203; 95% CI=0.05-0.821) were the dominant risk factors that affected the incidence of EGFR mutations in patients with lung adenocarcinoma at Arifin Achmad Hospital.Conclusion: Male, ex-smokers, and metastatic status (M1a) were the dominant risk factors for the incidence of EGFR mutations in lung adenocarcinoma patients at Arifin Achmad Hospital.

Mepolizumab’s (Anti-Interleukin-5) Role in Severe Asthma: A Literature Review Atikanur, Atikanur; Wijaya, Dewi; Esha, Indi; Simanjuntak, Arya Marganda
Jurnal Respirologi Indonesia Vol 44, No 2 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i2.494

One type of asthma that is difficult to treat is severe asthma, which is asthma that is uncontrolled even when the patient is taking medication or trigger factors. It can be treated with the finest therapy but will worsen if high-dose treatment is discontinued. Age, gender, obesity, hypersensitivity, and immunological factors are all directly related to the onset of asthma. A complicated illness, severe asthma has many clinical symptoms and treatment choices. Chronic airway inflammation and lung tissue remodeling are its defining features. This literature review aims to describe how mepolizumab works in patients with severe asthma. Mepolizumab mainly inhibits the IL-5 cytokine from binding to IL-5 receptor subunits through the nanomolar potential, which inhibits IL-5 from binding to receptors on the surface of eosinophils. In contrast to the placebo group, patients on mepolizumab had an average 50% decrease from the baseline Prednisone dosage. With Mepolizumab, the yearly exacerbation rate was 1.44 RR, while it was 2.12 RR with placebo. The injection of monoclonal antibodies, such as mepolizumab, as a form of therapy in addition to treating severe eosinophilic asthma is advised by the GINA guideline for 2022. Mepolizumab's mode of action blocks IL-5 from binding to receptors on eosinophil surfaces, which lowers eosinophil recruitment, activation, production, growth, and survival, as well as eosinophil-mediated inflammation.

The Role of Gut Microbiota as a Trigger for Exacerbations in Pulmonary Obstruction Disorder in General Wijaya, Dewi; Simatupang, Elvando Tunggul Mauliate; Putri, Yolanda Julia Perel; Pratiwi, Adelia; Anggraini, Dewi; Syam, Shaogi
Jurnal Respirasi Vol. 10 No. 3 (2024): September 2024
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v10-I.3.2024.257-264

Pulmonary diseases can be associated with the gastrointestinal (GI) system, particularly if an infection causes them. This relationship between organs is known as the gut-lung axis (GLA). Skin and mucosal surfaces are associated with microbiota (bacteria, fungi, viruses, macrophages, archaea, protists, helminths), which can trigger an immune response in GLA and serve a role in respiratory diseases. For instance, asthma can be inhibited by a specific antigen that is triggered by probiotics, the microorganisms found in the GI tract. Asthma incidence can be reduced by consuming fiber due to its ability to protect airways from infection. Pattern recognition receptors (PRRs) are the first immune component to identify microbial compounds in GI and lung epithelial cells. The PRRs then induce regulatory T-cell (T-reg) and Th-17 differentiation. Diet, antibiotics, and stress can all influence the structure and function of bacteria. This is known as dysbiosis. Lung microbiota can influence immune cell maturation and homeostasis. If the diversity of lung microbiota decreases, it will affect intestinal microbiota and may result in chronic respiratory disorders such as chronic obstructive pulmonary disease (COPD), asthma, and cystic fibrosis. This literature review explained how the interactions between the intestines and lungs can affect humans’ health and well-being.

Penerapan Metode Cooperative Script untuk Meningkatan Keterampilan Menulis Descriptive Text pada Siswa Kelas VIII-E Semester 1 SMP Negeri 3 Kalidawir Tahun Pelajaran 2017/2018 Wijaya, Dewi
Jurnal Pembelajaran dan Riset Pendidikan Vol 3 No 1 (2023): Volume 3, No. 1, Januari 2023
Publisher : Lembaga Penelitian dan Pengabdian Universitas Nahdlatul Ulama Blitar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28926/jprp.v3i1.693

Berdasarkan hasil observasi yang sudah dilakukan pada siswa kelas VIII-E di semester I SMPN 3 Kalidawir tepatnya tahun ajaean 2017/2018 diketahui jika nilai ketuntasan ssiwa dalam belajar masih rendah khususnya pada saat mempelajari keterampilan menulis. Keterampilan menulis yang dimaksud adalah menuis Descriptive Text. Guru menggunakan metode pembelajaran Cooperative Script pada penelitian tindakan ini dengan tujuan untuk meningkatkan nilai siswa dalam menulis Descriptive Text. Hasil penelitian adalah jika penerapan metode pembelajaran Cooperative Script pada keterampilan menulis Descriptive Text ternyata dapat meningkatkan nilai siswa. Pada saat siklus I nilai siswa dalma menulis sebanyak 61,8% dan pada saat siklus II hasil belajar siswa mnegalami peningkatan menjadi 91,2%.

PNEUMONIA NOSOKOMIAL AKIBAT KLEBSIELLA PNEUMONIAE POSITIF ESBL PADA PASIEN DENGAN MENINGIOMA FRONTALIS BESAR : LAPORAN KASUS Rahmadhani, Nadia Putri; Ananda, Pratama; Wijaya, Dewi
Jurnal Kesehatan Tambusai Vol. 6 No. 3 (2025): SEPTEMBER 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v6i3.49967

Pneumonia nosokomial (Hospital Acquired Pneumonia/HAP) adalah infeksi saluran pernapasan bawah yang terjadi ≥48 jam setelah pasien dirawat di rumah sakit dan tidak dalam keadaan inkubasi saat masuk. Klebsiella pneumoniae positif extended-spectrum beta-lactamase (ESBL) merupakan agen etiologi utama yang berhubungan dengan peningkatan morbiditas, mortalitas, serta lama hari rawat pada kasus HAP. Meningioma adalah tumor intrakranial primer yang berasal dari sel meningotelial pada meningen, khususnya lapisan arakhnoid. Tumor ini merupakan neoplasma jinak paling sering pada sistem saraf pusat, meskipun sebagian kecil dapat bersifat atipikal atau ganas. Pasien dengan meningioma, terutama yang menjalani perawatan jangka panjang, memiliki risiko lebih tinggi mengalami komplikasi seperti HAP. Laporan kasus ini menyoroti interaksi antara kondisi neurologis dasar dan infeksi nosokomial. Pemberian antibiotik empiris dapat memperbaiki prognosis. Seorang pasien perempuan berusia 44 tahun datang dengan keluhan sakit kepala disertai muntah. Pemeriksaan MRI menunjukkan adanya meningioma pada konveksitas frontal posterior kiri dengan ukuran 6x6x6 cm. Pada hari ke-5 perawatan di rumah sakit, pasien mengalami penurunan kesadaran yang disertai sesak napas. Pasien dirawat di ICU, dilakukan intubasi, dan diberikan antibiotik empiris meropenem sambil menunggu hasil kultur sputum. Hasil kultur menunjukkan Klebsiella pneumoniae positif ESBL. Setelah 3 hari terapi antibiotik, kesadaran pasien membaik, serta hasil pemeriksaan laboratorium dan radiografi toraks menunjukkan perbaikan. Pasien dengan keganasan memiliki risiko tinggi untuk mengalami pneumonia nosokomial selama perawatan rumah sakit yang berkepanjangan. Terapi antibiotik empiris sebagai penatalaksanaan awal memberikan prognosis yang baik dalam mencegah perburukan infeksi.

Immunology of Drug-Resistant Tuberculosis (DR-TB):A Literature Review Oinike, Irene; Wijaya, Dewi
Jurnal Respirologi Indonesia Vol 45 No 4 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i4.958

Drug-resistant tuberculosis (DR-TB) poses significant challenges to control efforts due to its complex pathogenesis and limited treatment options. DR-TB arises through primary infection with resistant strains or secondary resistance during the course of treatment. Secondary resistance is divided into intrinsic and acquired. In intrinsic resistance, infection is caused by TB germs that have evolved, causing resistance through several mechanisms, namely reducing cell membrane permeability, drug reflux, degradation and target modification, while acquired resistance is caused by chromosomal mutations in target genes during the treatment process. Resistance is driven by chromosomal mutations in key genes such as rpoB, katG, inhA, pncA, emb, gyrA/gyrB, rrs and others, leading to reduced drug susceptibility. This review summarizes immunological mechanisms relevant to resistance and current treatment approaches.

Association Between Factory Workers’ Profile with Chest X-ray Finding and Spirometry at Industrial Company of X Wijaya, Dewi; Esha, Indi; Adrianison, Adrianison; Simatupang, Elvando Tunggul Mauliate; Amarudin, Amarudin
Respiratory Science Vol. 6 No. 1 (2025): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v6i1.198

Background: Factory workers are a group at high risk of developing occupational lung abnormalities. Continuous exposure to dust, smoke, or gas particles during work processes may lead to progressive lung damage. Chest X-ray and spirometry are essential diagnostic tools for assessing both structural and functional lung changes, allowing early detection and prevention of occupational lung disability, especially among workers exposed to airborne pollutants. Method: This analytical observational study employed a cross-sectional design to analyze the association between factory workers’ profiles and chest X-ray and spirometry findings. Lung function was assessed using spirometry parameters, including Forced Vital Capacity (FVC), Forced Expiratory Volume in one second (FEV₁), and FEV₁/FVC ratio to identify restrictive or obstructive patterns. Data were collected using total sampling during periodic health examinations and analyzed with SPSS version 26.0. Descriptive statistics were used to summarize characteristics, while inferential analysis using Chi-square or Fisher’s exact tests was conducted to determine associations between categorical variables, with a significance level set at P<0.05. Results: A total of 260 factory workers participated, most with ≤5 years of work experience (60.76%). Comorbidities were significantly associated with both chest X-ray findings and lung function (P=0.034 and P=0.004). Smoking history and length of work also showed significant relationships with lung function (P=0.027 and P=0.019). Conclusion: There is a significant association between smoking history and length of work with changes in lung function. Meanwhile, comorbidities have a significant association with lung structure and lung function. Periodic evaluation using spirometry and chest X-ray is essential for early detection and prevention of occupational lung abnormalities among factory workers.

Upaya Penguasaan Vocabulary Teks Descritive melalui Pendekatan Scientific dengan Model Pendekatan Scientific dengan Model Guide Inquiry pada Siswa Kelas VIII-B Semester 2 SMP Negeri 3 Kalidawir Tulungagung Tahun Pelajaran 2018/2019 Wijaya, Dewi
Jurnal Pembelajaran dan Ilmu Pendidikan Vol 3 No 1 (2023): Volome 3, Nomor 1, Februari (2023)
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas Nahdlatul Ulama Blitar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28926/jpip.v3i1.760

Ditentukan, berdasarkan pengamatan yang dilakukan selama pelajaran bahasa Inggris di Kelas VIII-B, prestasi belajar siswa di bawah rata-rata. Hanya satu siswa yang mahir dari 26 yang mendapat nilai KKM 70, dan 10 siswa mendapat nilai antara 41 dan 69, sedangkan 15 siswa lainnya mendapat nilai 41. Hal ini karena guru tidak memberikan informasi yang jelas tentang Vocabulary Descriptive Text, meninggalkan kelas setelah pemberian tugas, menggunakan strategi atau metode yang dapat membantu siswa mengembangkan kreativitasnya, dan masih banyak siswa bermain sendiri sambil belajar. Untuk mencapai tujuan pembelajaran dan meningkatkan prestasi belajar siswa dalam menjawab pertanyaan tentang Vocabulary Descriptive Text, maka perlu dilaksanakan perbaikan pembelajaran dengan menggabungkan Model Guide Inquiry dengan Metode Pendekatan Saintifik. Penelitian ini menggunakan jenis penelitian tindakan kelas (PTK). Subyek penelitian adalah siswa kelas VIII-B. Sepanjang proses pembelajaran Vocabulary Descriptive Text juga dilakukan observasi. Hasil penelitian menunjukkan bahwa materi Vocabulary Descriptive Text di SMP Negeri 3 Kalidawir Tulungagung efektif dalam meningkatkan prestasi belajar siswa Kelas VIII-B dengan menggunakan Model Guide Inquiry yang dikombinasikan dengan Metode Pendekatan Saintifik. Peningkatan prestasi belajar terlihat pada persentase siswa yang nilai postesnya di atas KKM dengan nilai ketuntasan 38,5% siswa pada siklus I dan 88,5% pada siklus II.

Risk Factors for EGFR (Epidermal Growth Factor Receptor) Gene Mutations in Lung Adenocarcinoma Patients at Arifin Achmad Hospital, Riau Province Riensya, Bayu Aulia; Munir, Sri Melati; Wijaya, Dewi
Jurnal Respirologi Indonesia Vol 44 No 3 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i3.484

Background: Lung cancer is the first cause of oncological death worldwide. Guidelines made by various cancer associations, including PDPI-IASTO, regarding NSCLC recommend that all advanced stages of NSCLC undergo target genetic testing, such as EGFR mutations. The incidence of EGFR mutations in Asian populations is quite high.Methods: This was a retrospective observational analytic study with a cross-sectional study design.Results: The most unmodifiable risk factors were age ≥45 years (81.4%), male sex (70.6%), location of lung cancer on the right (52.9%), cancer size of ≥5 cm (100%), M1a metastases (57.8%), and no family history of malignancy (97.1%). The smoking status (ex-smoker) (P=0.022; OR=4.3; 95% CI=1.24-15.57), sex (male) (P=0.007; OR=3.409; 95% CI=1.406-8.268), and metastatic status (M1a) (P=0.025; OR=0.203; 95% CI=0.05-0.821) were the dominant risk factors that affected the incidence of EGFR mutations in patients with lung adenocarcinoma at Arifin Achmad Hospital.Conclusion: Male, ex-smokers, and metastatic status (M1a) were the dominant risk factors for the incidence of EGFR mutations in lung adenocarcinoma patients at Arifin Achmad Hospital.

Mepolizumab’s (Anti-Interleukin-5) Role in Severe Asthma: A Literature Review Atikanur, Atikanur; Wijaya, Dewi; Esha, Indi; Simanjuntak, Arya Marganda
Jurnal Respirologi Indonesia Vol 44 No 2 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i2.494

One type of asthma that is difficult to treat is severe asthma, which is asthma that is uncontrolled even when the patient is taking medication or trigger factors. It can be treated with the finest therapy but will worsen if high-dose treatment is discontinued. Age, gender, obesity, hypersensitivity, and immunological factors are all directly related to the onset of asthma. A complicated illness, severe asthma has many clinical symptoms and treatment choices. Chronic airway inflammation and lung tissue remodeling are its defining features. This literature review aims to describe how mepolizumab works in patients with severe asthma. Mepolizumab mainly inhibits the IL-5 cytokine from binding to IL-5 receptor subunits through the nanomolar potential, which inhibits IL-5 from binding to receptors on the surface of eosinophils. In contrast to the placebo group, patients on mepolizumab had an average 50% decrease from the baseline Prednisone dosage. With Mepolizumab, the yearly exacerbation rate was 1.44 RR, while it was 2.12 RR with placebo. The injection of monoclonal antibodies, such as mepolizumab, as a form of therapy in addition to treating severe eosinophilic asthma is advised by the GINA guideline for 2022. Mepolizumab's mode of action blocks IL-5 from binding to receptors on eosinophil surfaces, which lowers eosinophil recruitment, activation, production, growth, and survival, as well as eosinophil-mediated inflammation.

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