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All Journal Indonesian Journal of Pure and Applied Chemistry
Firdaus, Giska Ristianty
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Biochemistry, Genetics & Molecular Biology Chemistry

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AKTIVITAS ANTIBAKTERI KURKUMIN DAN KOMPLEKS TEMBAGA (II) KURKUMIN TERHADAP S.AUREUS DAN E.COLI Firdaus, Giska Ristianty; Silalahi, Imelda Hotmarisi; Ardiningsih, Puji
Indonesian Journal of Pure and Applied Chemistry Vol 7, No 2 (2024)
Publisher : Tanjungpura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26418/indonesian.v7i2.77806

Abstract

Copper (II) complex of curcumin was prepared from the reaction between curcumin and a metal precursor (CuCl2.2H2O) in ethanol with a mole ratio curcumin to metal 2:1. The FTIR spectrum of Cu2+-curcumin shows a change in the absorption band and a shift in the wave number, especially in the absorption band of the phenolic –OH group 3510.45 cm-1 which is a stretching vibration that becomes wider and shifts to a larger wave number, namely 3514.30 cm-1. Compared with free curcumin spectrum the absorption band of the C=O functional group shows a change where in free curcumin is at 1627.92 cm-1 while in the Cu2+-curcumin complex the is at 1735.93 cm-1 this indicate the coordination of metal ions with curcumin. The IR spectrum shows a typical absorption band for the metal oxygen group, Cu-O 480.28 cm-1 in the Cu2+-curcumin complex. The UV-Vis spectrum of the Cu2+-curcumin complex show a shift towards a larger wavelength (red shift/batochromic) of (~2 nm). Antibacterial activity of Cu2+-curcumin complex compound is active in inhibiting S.aureus and E.coli. After complexation, the activity against the tested microorganisms generally increased and the complex showed higher activity than free curcumin.
Co-Authors Imelda Hotmarisi Silalahi Puji Ardiningsih