Article Per Year (5 Year)
p-Index From 2020 - 2025
0.408
P-Index
This Author published in this journals
All Journal Dental Journal (Majalah Kedokteran Gigi)
Santosh, Arvind Babu Rajendra
Unknown Affiliation
Dentistry

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Single nucleotide polymorphisms: A paradigm in oral disease research Ummer, Hiba; Santosh, Arvind Babu Rajendra; Surboyo, Meircurius Dwi Condro; Chitipothu, Mani Deepthi; Sivanandham, Shamala
Dental Journal Vol. 57 No. 3 (2024): September
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v57.i3.p234-240

Abstract

Background: A higher occurrence of oral cancer is observed in South Asian and Southeast Asian countries when compared with other countries in the world. Cancer, a disease with complex pathophysiology, has been linked to chronic inflammation. Inflammation has been considered an important component of tumor initiation and progression. This is supported by the fact that many cancers arise at the sites of chronic inflammation, but the exact mechanism by which inflammation influences cancer is unknown. Purpose: This review article correlates single nucleotide polymorphisms (SNPs), chronic inflammation, and oral cancer. The article emphasizes the critical role that SNPs play in oral cancer susceptibility, progression, and prognosis. This involves discussing the impact of specific SNPs on oral cancer risk and patient outcomes. Review: Gene polymorphism has been documented in the molecular pathogenesis of various cancers, including oral cancer, and SNPs are the most common form of gene polymorphism. Genetic variation has been documented in the molecular pathogenesis of various cancers, including oral cancer, and SNPs are the most common form of gene polymorphism. SNPs have been documented in inflammatory conditions as well as in various diseases. Conclusion: SNPs have phenotypic consequences and therefore can serve as genetic fingerprints. The upregulation or downregulation of genes is able to drive oral carcinogenesis.
Validation of the Jamaican version of the Oral Health Impact Profile (OHIP-14) in adults: JAM-OHIP study Brown, Michelle Antonette; Thomas, Biney; de Souza, Juliana Sena; Soares Rech, Rafaela; Santosh, Arvind Babu Rajendra; Baumgarten, Alexandre; Campbell-Blagrove, Susanna
Dental Journal Vol. 57 No. 4 (2024): December
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v57.i4.p286-291

Abstract

Background: The Oral Health Impact Profile (OHIP-14) is a widely used tool for measuring the effects of oral health-related quality of life (OHRQoL). However, the validity of the OHIP-14 in the Jamaican context, referred to as the Jamaican Oral Health Impact Profile (JAM-OHIP), has yet to be established. Purpose: To determine the validity of the Jamaican language version of the OHIP in evaluating the OHRQoL of Jamaican adults. Methods: The original English version of the Oral Health Impact Profile (OHIP-14) was translated into the Jamaican language using forward and backward translation. The JAM-OHIP was used to evaluate the OHRQoL of 236 individuals at the University of the West Indies Dental Polyclinic. The overall fit was checked using a chi-square test (p > 0.05), comparative fit index (CFI), Tucker–Lewis index (TLI), root mean square error of approximation (RMSEA), and standardized root mean square residual (SRMR). Results: More DMFT (p < 0.01) was associated with high JAM-OHIP scores, and the most impacted domain was physical pain. Cronbach’s alpha and the standardized item alpha for the JAM-OHIP were 0.82. The overall fitting results for the CFA were χ²(68) = 80.558, p = 0.142, and χ²/g.l. = 1.185. The CFI and TLI were 0.996 and 0.994, respectively. The SRMR was 0.072 and the RMSEA was 0.028 (CI95% = [0.000; 0.050]) p = 0.953. Conclusions: The JAM-OHIP instrument was shown to be reliable and valid for the assessment of OHRQoL in the Jamaican adult population.
Co-Authors Baumgarten, Alexandre Brown, Michelle Antonette Campbell-Blagrove, Susanna Chitipothu, Mani Deepthi de Souza, Juliana Sena Sivanandham, Shamala Soares Rech, Rafaela Surboyo, Meircurius Dwi Condro Thomas, Biney Ummer, Hiba