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All Journal Dental Journal (Majalah Kedokteran Gigi) Indonesian Journal of Dental Medicine Sinnun Maxillofacial Journal
Puspasari, Karlina
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Dentistry Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Prevalensi Lesi Oral sebagai Manifestasi HIV/AIDS pada Orang Dengan HIV (ODHIV) yang Mengonsumsi Highly Active Antiretroviral Therapy di Komunitas Mahameru Surabaya Indonesia Radithia, Desiana; Ernawati, Diah Savitri; Bakti, Reiska Kumala; Pratiwi, Aulya Setyo; Ayuningtyas, Nurina Febriyanti; Mahdani, Fatma Yasmin; Pasaribu, Togu Andrie Simon; Puspasari, Karlina; Pramitha, Selviana Rizky; Dewi, Gremita Kusuma
Sinnun Maxillofacial Journal Vol. 6 No. 01 (2024): April 2024
Publisher : Fakultas Kedokteran Gigi Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/smj.v6i01.127

Abstract

Pendahuluan: Terjadinya lesi oral pada Orang Dengan HIV (ODHIV) telah banyak dihubungkan dengan peningkatan viral load, penurunan jumlah CD4+, dan konsumsi Highly Active Antiretroviral Therapy (HAART) yang walaupun penggunaannya dapat meningkatkan kondisi umum ODHIV, tetapi penggunaan dalam jangka panjang juga akan memicu berbagai perubahan secara sistemik dan lokal. Tujuan Penelitian: Penelitian ini bertujuan untuk mendata prevalensi terjadinya lesi oral pada ODHIV yang menggunakan HAART. Metode: Penelitian ini menggunakan jenis penelitian observasi cross sectional dengan total sampling sesuai dengan STOBE statement. Data dicatat pada formulir kuesioner dan formulir pemeriksaan klinis. Hasil: Sebanyak total 40 orang peserta dilaporkan dalam penelitian ini. Jenis HAART yang paling banyak dilaporkan penggunaannya dalam jangka panjang tanpa perubahan adalah TLD (27,5%), sementara jenis terapi dengan perubahan regimen adalah terapi awal dengan Duviral Neviral menjadi terapi dengan TLD (12,5%). Durasi terapi HAART selama lebih dari 3 tahun tercatat pada 29 peserta (72,5%) dan durasi terapi kurang dari 3 tahun tercatat pada 11 peserta (27,5%). Lesi oral yang paling banyak diobservasi adalah diffuse oral hyperpigmentation (47,62%), diikuti oleh coated tongue (23,81%), traumatic ulcer (4,76%), linea alba (4,76%), torus palatinus (4,76%), dan lesi-lesi lainnya. Kesimpulan: Lesi oral yang paling banyak ditemukan adalah oral diffuse hyperpigmentation dan korelasinya dengan penggunaan HAART masih perlu ditelaah lebih lanjut.
White sponge nevus as a hereditary disease: A brief narrative review Mahdani, Fatma Yasmin; Puspasari, Karlina; Manuaba, Ida Bagus Pramana Putra; Putri, Salsabila Fitriana; Ayunnisa, Naqiya; Ernawati, Diah Savitri; Hendarti, Hening Tuti
Indonesian Journal of Dental Medicine Vol. 8 No. 1 (2025): Indonesian Journal of Dental Medicine
Publisher : Faculty of Dental Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijdm.v8i1.2025.49-52

Abstract

Background: White sponge nevus (WSN) is an autosomal dominant hereditary genetic disorder characterized by thickened keratin in the oral mucosa that appears folded, wavy, spongy, thick, and rough. WSN do not have the potential to become malignant, but an accurate diagnosis is still needed to prevent unnecessary treatment and reduce potential remissions and exacerbations due to infection. Purpose: to provide a detailed description of white sponge nevus as a hereditary disease by means of narrative review. Review: A literature search using ScienceDirect and PubMed yielded results between 2012 and 2024. The keywords of the search strategy were “hereditary disease” and “white sponge nevus” or “Cannon’s disease” or “white folded gingivostomatitis” or “leukokeratosis.”. White sponge nevus (WSN) was first discovered by Hyde in 1909 and usually occurs in children and people under 20 years old. The main etiology of WSN is an autosomal dominant hereditary genetic disorder; KRT4 and KRT13 are specific keratin encoders that cause WSN, and there are predisposing factors such as bacterial infection, smoking, and alcohol consumption. Conclusion: In determining the diagnosis of WSN, it is necessary to carry out blood tests, subjective examinations, objective examinations, and supporting examinations in the form of exfoliative cytology and biopsies. As well as the need for comprehensive treatment, even though the prognosis of this disorder is good.
Oral field cancerization: Genetic profiling for a prevention strategy for oral potentially malignant disorders Puspasari, Karlina; Pasaribu, Togu Andrie Simon; Surboyo, Meircurius Dwi Condro; Ayuningtyas, Nurina Febriyanti; Santosh, Arvind Babu Rajendra; Ernawati, Diah Savitri
Dental Journal (Majalah Kedokteran Gigi) Vol. 56 No. 3 (2023): September
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v56.i3.p189-196

Abstract

Background: Oral cancer therapy, such as radiation or surgical treatment, has pernicious long-term effects that patients suffer throughout their life, the disability being considerable with delayed diagnosis. It is well known that many oral cancers develop from oral potentially malignant disorders (OPMDs). Patients diagnosed with OPMDs may have an increased risk of developing cancer anywhere in the oral cavity. Early detection and intervention could be essential prevention strategies to inhibit oral cancer progression. OPMDs may not immediately develop into carcinoma. However, this condition provides a "field” of specific abnormalities wherein evolving altered genetic cells can be explained with the "field cancerization” concept. Purpose: This review aims to describe the "field cancerization” concept in oral cancer and OPMD, which is expected to contribute to a better clinical management strategy for oral cancer prevention. Review: "Oral field cancerization” describes oral cancers that develop in multifocal areas of pre-cancerous changes. It can be found as histologically abnormal tissue surrounding the tumor, suggesting that oral cancer often consists of multiple independent lesions. Conclusion: The oral field cancerization concept should prompt healthcare professionals to remind their patients that frequent oral examination with histological studies and molecular testing is mandatory for those at high risk of developing malignancies.
Co-Authors Ayunnisa, Naqiya Desiana Radithia, Desiana Dewi, Gremita Kusuma Diah Savitri Ernawati Fatma Yasmin Mahdani Hening Tuti Hendarti Manuaba, Ida Bagus Pramana Putra Nurina Febriyanti Ayuningtyas Pasaribu, Togu Andrie Simon Pramitha, Selviana Rizky Pratiwi, Aulya Setyo Putri, Salsabila Fitriana Reiska Kumala Bakti Santosh, Arvind Babu Rajendra Surboyo, Meircurius Dwi Condro