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Febrianti, Eliza
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Environmental Science Immunology & microbiology Languange, Linguistic, Communication & Media

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Analysis of Liver Histology Several Fish in the Air Kotok River in the Gold Mining Area, Lebong Regency Lestari, Dian Fita; Febrianti, Eliza; Wulansari, Shahnaz Sabrina; Putra, Apriza Hongko
JURNAL PEMBELAJARAN DAN BIOLOGI NUKLEUS Vol 9, No 2: Jurnal Pembelajaran Dan Biologi Nukleus July 2023
Publisher : Fakultas Keguruan dan Ilmu Pendidikan Universitas Labuhanbatu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36987/jpbn.v9i2.4020

Abstract

Fish have habitats that are easily exposed to contamination from the environment such as heavy metal waste which can cause changes in the structure and function of body tissues. One type of waste that enters the river in the Lebong Regency River is gold mining processing waste that uses mercury and cyanide. Heavy metals can enter organisms and accumulation and biomagnification of mercury can occur in the bodies of aquatic biota such as fish. There has been no research related to fish histology in the Lebong gold mining area, so the aim of this research was to determine the histological condition of the liver organs of several fish in the form of Hemibagrus nemurus, Rasbora sp, Trichogaster trichopterus, and Macrognathus circumcinctus in the Air Kotok river in the gold mining area of Lebong Regency. The research was conducted using the paraffin method with hematoxylin-eosin staining. Data were analyzed descriptively qualitatively based on the histology of the fish liver. The results of the research on the liver histology, it shows damage to the fish liver structure which includes vacuolization, congestion, pyknosis, dilated sinusoids, melanomacrophages and leukocyte infiltration. The damage to the hepatocytes of this fish can be used as a bio-indicator of exposure to toxic substances in the Air Kotok river, one of which is heavy metal activity from gold mining, which can be a threat to the health and survival of the fish.Keywords: Bengkulu, gold mining waste, heavy metal, hepa
Hepatoprotective Activity of Hibiscus Flowers (Hibiscus rosa-sinensis) and Soursop Leaves (Annona muricata) Mix Infusion in Mus musculus Post Hyperuricemia Induction Lestari, Dian Fita; Atmaja, Vestidhia Yunisya; Fatimatuzzahra, Fatimatuzzahra; Wulansari, Shahnaz Shabrina; Febrianti, Eliza
JURNAL PEMBELAJARAN DAN BIOLOGI NUKLEUS Vol 11, No 2: Jurnal Pembelajaran Dan Biologi Nukleus June 2025
Publisher : Universitas Labuhanbatu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36987/jpbn.v11i2.6931

Abstract

Background: Liver has many functions in the metabolic system and detoxification of substances that are harmful to the body. Chemical intoxication due to drug use might induce liver damage. A histology examination can indicate liver damage induced by a chemical substance, as well as the condition of tissue structure and function associated with the disease. This study aims to investigate the hepatoprotective effect of mix infusion of hibiscus flowers and soursop leaves on the liver histological structure in mice induced by hyperuricemia using potassium oxonate. Methodology: This study used an experimental group design, involving 8-week-old mice. The groups were divided as follows: A1 (control), A2 (Potassium oxonate), A3 (allopurinol), A4 (infusion 25 %), A5 (infusion 35 %), and A6 (infusion 45 %). Histological image was examined using an optilab with five fields of view. Findings: The study's revealed that the control group had a normal liver histology structure, whereas the hyperuricemia treatment group experienced significant liver damage, including congestion and leukocyte infiltration, and the allopurinol treatment group experienced significant damage, including leukocyte infiltration and necrosis. Therapy with a combined infusion of hibiscus flowers and soursop leaves shown a hepatoprotective effect. Based on histological analysis, the 25 % concentration provided the greatest hepatoprotective impact when compared to other infusion concentration. Mix infusion of hibiscus flowers and soursop leaves demonstrates heproprotective activity in hyperuricemia mice induced by potassium oxonate. Contribution: This study demonstrates that the mix infusion of hibiscus flowers and soursop leaves has the potential to be a hepatoprotective agent, but further research is needed regarding long-term effects
Co-Authors Atmaja, Vestidhia Yunisya Fatimatuzzahra Fatimatuzzahra Lestari, Dian Fita Putra, Apriza Hongko Wulansari, Shahnaz Sabrina Wulansari, Shahnaz Shabrina