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Dakhil, Kareema A.
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Combination of Irisin, Uric Acid, and Pro-Inflammatory Cytokine To Distinguish Gout Patients From Healthy Controls in The Governorate of Thi-Qar Dakhil, Kareema A.; Aziz, Manal A.; Majid, Wajdy J.
Academia Open Vol 8 No 2 (2023): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.8.2023.7844

Abstract

This study aimed to investigate the potential of combining uric acid levels with pro-inflammatory cytokines, specifically interleukin-1β (IL-1β) and the myokine irisin, to enhance the precision of gout diagnosis. The patient group comprised 80 individuals with gout, while the control group included 70 healthy subjects. Serum levels of IL-1β and irisin were measured in both groups, and Pearson correlation analysis was employed to assess their relationships with serum uric acid. Results revealed that gout patients exhibited significantly higher levels of IL-1β and serum uric acid but lower irisin levels compared to the control group. Negative correlations were observed between irisin and IL-1β, as well as between irisin and uric acid. Conversely, a positive correlation was found between serum uric acid and IL-1β. Receiver operating characteristic (ROC) curve analysis demonstrated high diagnostic accuracy for both IL-1β and irisin in discriminating gout patients from healthy individuals, suggesting their potential utility as diagnostic indicators for gout. This study underscores the promise of combining IL-1β, irisin, and uric acid measurements to enhance the accuracy of gout diagnosis, paving the way for further multicenter trials to validate this approach's effectiveness. Highlights: Novel Diagnostic Approach: This study proposes a novel diagnostic approach for gout by combining serum levels of uric acid with pro-inflammatory cytokines IL-1β and myokine irisin, demonstrating its potential to enhance precision. Correlation Insights: The study reveals significant correlations between uric acid, IL-1β, and irisin levels, shedding light on the intricate relationship between inflammation, myokines, and gout pathophysiology. Diagnostic Accuracy: High diagnostic accuracy, as indicated by ROC curve analysis, underscores the clinical utility of IL-1β and irisin as potential indicators for gout diagnosis, offering a promising avenue for improved clinical assessment. Keywords: Gout Diagnosis, Interleukin-1β, Irisin, Uric Acid, Pro-Inflammatory Cytokines.
Evaluating Thyroid Function in Obese Adults in Dhi Qar, Iraq Dakhil, Kareema A.
Indonesian Journal on Health Science and Medicine Vol. 2 No. 2 (2025): Oktober
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i2.236

Abstract

Obesity is a global public health challenge with profound endocrine and metabolic implications, particularly affecting the thyroid axis, which regulates basal metabolic rate and energy expenditure. Emerging evidence suggests that obese individuals may exhibit altered thyroid function even in the absence of overt thyroid disease. Despite existing studies, limited data are available from Iraq regarding the impact of obesity and aging on thyroid hormone profiles. This study aimed to evaluate thyroid hormone levels—TSH, free T4, and free T3—in obese adults across two age groups and compare them with non-obese healthy controls in Dhi Qar, Iraq. A cross-sectional study of 180 male participants revealed significant hormonal alterations. Elderly obese individuals (Group B, 60–75 years) had the highest TSH levels (4.16 ± 1.25 μIU/mL), followed by younger obese adults (Group A, 35–45 years, 3.45 ± 1.10 μIU/mL), compared with healthy controls (2.12 ± 0.80 μIU/mL). Both obese groups exhibited reduced fT4 and fT3 levels, most pronounced in elderly subjects (0.86 ± 0.14 ng/dL and 2.25 ± 0.30 pg/mL, respectively). This is one of the first studies in Iraq to demonstrate a recurrent association between obesity, age, and thyroid hormone dysregulation, pointing to subclinical hypothyroidism. The findings underscore the importance of routine thyroid function screening in obese individuals, particularly the elderly, for early detection and prevention of endocrine complications. Highlights: Pseudomonas aeruginosa effectively removed up to 70% of organic pollutants (COD) and over 60% of nitrogen compounds from wastewater. The bacteria showed high heavy metal removal efficiency, with 87.2% for nickel and 77.5% for zinc. Nitrate removal was the lowest (30.3%), highlighting the need for optimized treatment conditions to improve efficiency.
The Impact of Lactobacillus Infection During Pregnancy on Metabolic and Immune Parameters in Women 40 Days Post-Delivery: Dampak Infeksi Lactobacillus Selama Kehamilan terhadap Parameter Metabolik dan Imun pada Wanita 40 Hari Pasca Persalinan Alnawas, Zahraa Ali Nashoor; Dakhil, Kareema A.
Academia Open Vol. 10 No. 2 (2025): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.10.2025.13014

Abstract

Background: Lactobacillus normally plays a protective role in the maternal microbiome, yet under certain dysbiotic conditions it may be associated with metabolic and immunological disturbances during pregnancy. Specific Background: Evidence regarding postpartum health consequences of Lactobacillus infection remains limited, particularly its link to inflammatory and metabolic alterations. Gap: No studies have assessed metabolic and immune outcomes 40 days postpartum among women infected with Lactobacillus during pregnancy. Aim: This study examines postpartum metabolic profiles, inflammatory markers, and immune balance in women previously exposed to Lactobacillus infection. Methods: A cross-sectional comparison of 100 infected and 100 healthy women was conducted using clinical, biochemical, and immunological assessments. Results: Infected women exhibited higher fasting glucose, cholesterol, triglycerides, blood pressure, CRP, IL-6, IL-8, TNF-α, TPOAb, and TgAb, alongside lymphopenia and a Th1-dominant immune shift. Novelty: This study provides early evidence that Lactobacillus-associated dysbiosis in pregnancy may contribute to sustained metabolic and immune dysregulation beyond delivery. Implications: Findings highlight the importance of monitoring postpartum women with pregnancy-related dysbiosis and suggest a potential role of microbiome alteration in long-term maternal health. Highlights:• Distinct postpartum metabolic disturbances in infected women• Marked inflammatory activation associated with dysbiosis• Altered Th1/Th2 balance persisting after delivery Keywords: Lactobacillus Infection, Postpartum Metabolism, Immune Imbalance, Cytokines, Maternal Health
Co-Authors Alnawas, Zahraa Ali Nashoor Aziz, Manal A. Majid, Wajdy J.