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Saleh, Eman Naji
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Star Anise Reverses Benzopyrene-Induced Immune Dysfunction in Rats Saleh, Eman Naji; Saeed, Iktefa Abdul Hamid Mohammed; latef, Nedhal ibrahim
Academia Open Vol 9 No 2 (2024): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.9.2024.9575

Abstract

Background: Benzopyrene (B[a]P), a polycyclic aromatic hydrocarbon, is known for its carcinogenic and immunotoxic effects, posing significant health risks upon exposure. Specific Background: Despite numerous studies, effective therapeutic strategies to mitigate B[a]P-induced toxicity remain limited. Star anise, a medicinal plant with anti-inflammatory properties, holds potential as a protective agent against such toxicity. Knowledge Gap: The impact of star anise on B[a]P-induced immunotoxicity, particularly on hematological parameters, has not been thoroughly investigated. Aims: This study aimed to explore the effects of B[a]P intoxication and its treatment with star anise on hematological parameters in rats. Methods: Thirty male Sprague Dawley rats were divided into six groups: Control, B[a]P, and varying doses of star anise (125 mg/kg, 120 mg/kg + B[a]P, 125 mg/kg + B[a]P, 130 mg/kg + B[a]P). Blood samples were analyzed using an auto blood analyzer. Results: While erythrogram parameters showed no significant differences among groups, B[a]P exposure significantly increased WBC parameters (Mid, Gran, L, and total WBC counts), indicating an inflammatory and immunosuppressive response. Treatment with star anise significantly reduced these parameters, suggesting its protective effects. Novelty: This study is the first to demonstrate the efficacy of star anise in mitigating B[a]P-induced leukocytosis and immune toxicity in rats. Implications: These findings highlight the potential of star anise as a therapeutic agent against B[a]P-induced immunotoxicity, warranting further investigation into its clinical applications. Highlights: Benzopyrene Exposure: Increases WBC parameters, indicating immune response. Star Anise Treatment: Reduces WBC counts, showing protective effects. Novel Findings: Star anise mitigates B[a]P-induced immunotoxicity in rats. Keywords: Benzopyrene, Star Anise, Hematological Parameters, Immunotoxicity, Rats
Effects of benzopyrene experimental intoxication and its treatment by star anise on hematological parameters in rats Saleh, Eman Naji; Iktefa Abdul Hamid Mohammed Saeed; Nedhal ibrahim latef
JOURNAL OF MEDICAL AND HEALTH SCIENCE Vol. 1 No. 2 (2023): December
Publisher : Universitas Muhammadiyah Sidaorjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/anamnetic.v1i2.1587

Abstract

This study aimed to explore the effects of benzopyrene experimental intoxication and its treatment by star anise on hematological parameters in rats. 30 male white Swiss rats (Sprague Dawley), aged 3-4 months and weighing between 170-210 g. The rats were divided into six groups: Control (G1), B[a]P (G2), Star Anise 125 mg/kg bw (G3), Star Anise 120 mg/kg bw + B[a]P (G4), Star Anise 125 mg/kg bw + B[a]P (G5), and Star Anise 130 mg/kg bw + B[a]P (G6). Blood was collected by cardiac puncture at end of experiment by using tubes with EDTA and hematological parameters were estimated by using auto blood analyzer. Erythrogram didn’t showed any significant differences between studied groups, while These results showed that exposure to benzopyrene significantly increased all measured WBC parameters, indicating an inflammatory and immunosuppressive response. The mean values of Mid, Gran, L, and total WBC counts in Benzo group were 3.93 ± 0.97, 12.26 ± 1.08, 10.01 ± 1.07, 25.46 ± 1.29, respectively. The mean values of Mid, Gran, L, and total WBC counts in treatment groups significantly decreased in comparison with Benzo group. They are 1.11 ± 0.01, 4.41 ± 0.52, 5.10 ± 0.92, and 10.27 ± 0.31, respectively. These results indicated that benzopyrene can induce an immune response with leukocytosis and a population increase in the absolute granulocyte and lymphocyte, those treatments can reduce these values, indicating the potential protective effects of them on benzopyrene immune toxicity. In conclusion, these results show that the treatment of rats with benzopyrene caused changes in a number of WBC parameters that reflects an immune inflammatory response and could also reflect immunosuppression without any effects on erythrogram. Such changes were reduced by the treatment with Star anis showing higher efficacy, possibly indicating a role for these medicinal plants as protective agents against benzopyrene-induced immunotoxicity.
Plesiomonas Shigelloides: Unraveling the Mysteries of a Neglected Enteric Pathogen: Plesiomonas Shigelloides: Mengungkap Misteri Patogen Enterik yang Terabaikan Altaee, Zainab Agab; Farhan, Rana Salim; Jameel, Nabaa Qais; Saleh, Eman Naji
Indonesian Journal on Health Science and Medicine Vol. 1 No. 2 (2024): October
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v1i2.30

Abstract

The oxidase-positive, motile, Gram-negative bacteria Plesiomonas shigelloides is found all across the natural world. Additionally, it is a major pathogen that mostly causes disorders of the intestines in humans. Most of these illnesses are characterised by diarrhoea, which may be watery, invasive, or chronic in nature. There have been reports of intestinal illnesses caused by Plesiomonas that were spread by food and water. There are a number of extraintestinal diseases caused by P. shigelloides, the most prevalent of which are sepsis and meningitis, both of which are associated with significant fatality rates. Phylogenetically closely related to other Enterobacteriaceae species, P. shigelloides differs biochemically from them. A single biovar, with over a hundred serovars documented. Some have proposed P. shigelloides as a "natural" vaccination against shigellosis since it is thermo-, alkali-, acido-, and halotolerant. There are some intestinal media that are known to limit the development of Plesiomonas, and in the lab, it looks barely there on the surface of many agar plates. The antibiotic sensitivity patterns of Plesiomonas are somewhat peculiar, and the amount of the inoculum determines how susceptible the bacteria are to certain drugs. One distinguishing feature of high bacterial densities in the presence of certain β-lactam antibiotics is the development of significant cell filamentation Highlights: Pathogen: Causes diarrheal diseases, sepsis, and meningitis in humans. Characteristics: Gram-negative, motile, tolerates heat, alkali, acid, and salt. Antibiotics: Susceptibility varies; β-lactams cause cell filamentation in high densities. Keywords: Plesiomonas shigelloides, bacteria, diarrhea
Preparation and Characterization Evaluation The Zno Nanoparticles on Lymphocyte Vitality: Persiapan dan Evaluasi Karakterisasi Nanopartikel Zno pada Vitalitas Limfosit Lateff, Nedhal Ibrahim; Al-Obaidi, Fiham Jassim; Hameed, Ashwaq Talib; Saleh, Eman Naji
Indonesian Journal on Health Science and Medicine Vol. 1 No. 2 (2024): October
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v1i2.31

Abstract

The oxidase-positive, motile, Gram-negative bacteria Plesiomonas shigelloides is found all across the natural world. Additionally, it is a major pathogen that mostly causes disorders of the intestines in humans. Most of these illnesses are characterised by diarrhoea, which may be watery, invasive, or chronic in nature. There have been reports of intestinal illnesses caused by Plesiomonas that were spread by food and water. There are a number of extraintestinal diseases caused by P. shigelloides, the most prevalent of which are sepsis and meningitis, both of which are associated with significant fatality rates. Phylogenetically closely related to other Enterobacteriaceae species, P. shigelloides differs biochemically from them. A single biovar, with over a hundred serovars documented. Some have proposed P. shigelloides as a "natural" vaccination against shigellosis since it is thermo-, alkali-, acido-, and halotolerant. There are some intestinal media that are known to limit the development of Plesiomonas, and in the lab, it looks barely there on the surface of many agar plates. The antibiotic sensitivity patterns of Plesiomonas are somewhat peculiar, and the amount of the inoculum determines how susceptible the bacteria are to certain drugs. One distinguishing feature of high bacterial densities in the presence of certain β-lactam antibiotics is the development of significant cell filamentation Highlights: Pathogen: Causes diarrheal diseases, sepsis, and meningitis in humans. Characteristics: Gram-negative, motile, tolerates heat, alkali, acid, and salt. Antibiotics: Susceptibility varies; β-lactams cause cell filamentation in high densities. Keywords: Plesiomonas shigelloides, bacteria, diarrhea
Co-Authors Al-Obaidi, Fiham Jassim Altaee, Zainab Agab Farhan, Rana Salim Hameed, Ashwaq Talib Iktefa Abdul Hamid Mohammed Saeed Jameel, Nabaa Qais latef, Nedhal ibrahim Lateff, Nedhal Ibrahim Nedhal ibrahim latef Saeed, Iktefa Abdul Hamid Mohammed