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Pengaruh Konseling Obat Terhadap Pengetahuan dan Sikap Pasien Kolestrol di Rawat Jalan RS Advent Medan br. Silalahi, Aancel; br. Sembiring, Novitaria; Hanjaya, Hanjaya; Razoki, Razoki; Neswita, Elfia
Ranah Research : Journal of Multidisciplinary Research and Development Vol. 6 No. 5 (2024): Ranah Research : Journal Of Multidisciplinary Research and Development (Juli 20
Publisher : Dinasti Research

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Abstract

Counseling is a practice that is needed by pharmacists because it provides significant benefits to patients. One of the important pharmaceutical services is counseling. Counseling, which comes from the word "advice," refers to the process of giving advice, interacting in discussions, and exchanging opinions. Good understanding and increased compliance will contribute to the achievement of the patient's treatment goals. Based on a study conducted on patients with cholesterol disease at Medan Adventist Hospital, data was obtained prospectively through the use of pretest and posttest questionnaires. The total number of participants analyzed was 50 people. To analyze the data using a simple linear regression method, as well as conduct validity and reliability tests. In addition, the paired t-test and the crosstab chi square test were also applied to evaluate the relationship between the characteristics and the research. Based on the results of the analysis of respondent characteristic data, it is known that there are 32% or 16 male respondents and 68% or 34 female respondents. This shows that the majority of respondents are women.
Formulasi dan Uji Aktivitas Sediaan Gel dari Fraksi Aktif Daun Sambiloto (Andrographis paniculata (Burm.f.) Nees) Sebagai Pengobatan Luka Diabetes Nazara, Gita Afifah; Br. Sembiring, Novitaria; Br. Ginting, Astriani Natalia
Herbal Medicine Journal Vol 9 No 1 (2026): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v9i1.224

Abstract

Diabetes mellitus is a chronic disease with an increasing prevalence and is often accompanied by complications such as diabetic ulcers, which are highly susceptible to infection, particularly by Staphylococcus aureus. Long-term use of antibiotics may lead to bacterial resistance, highlighting the need for alternative therapies based on natural products. Sambiloto leaves (Andrographis paniculata) contain bioactive compounds such as andrographolide, flavonoids, and phenolic compounds with antibacterial activity. A gel formulation was selected due to its ease of application and suitability for topical use on wounds. This study was a laboratory experimental study. Sambiloto leaves were extracted using the maceration method with 96% ethanol, followed by successive fractionation to obtain the aqueous fraction. The aqueous fraction was formulated into gel preparations at concentrations of 25%, 50%, and 75%. Antibacterial activity against Staphylococcus aureus was evaluated using the disc diffusion method, with clindamycin gel as a positive control and gel base as a negative control. Physical stability evaluations included organoleptic properties, homogeneity, pH, and spreadability. The results showed that the aqueous fraction of sambiloto leaves exhibited the highest antibacterial activity in a concentration-dependent manner. The 75% concentration demonstrated the greatest inhibition zone, although it was still lower than that of clindamycin. All gel formulations met the physical stability parameters and have potential to be developed as topical antibacterial preparations.