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All Journal Jambura Journal of Health Sciences and Research Jurnal Prima Medika Sains Journal of Multidisciplinary Applied Natural Science Jurnal Locus Penelitian dan Pengabdian Buletin Kedokteran dan Kesehatan Prima Ranah Research : Journal of Multidisciplinary Research and Development Journal of Pharmaceutical and Sciences. Jurnal Sains Farmasi dan Kesehatan Jurnal Indah Sains dan Klinis Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Razoki, Razoki
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Efektivitas madu sebagai gastroprotektif pada tikus putih yang diinduksi aspirin bedasarkan hasil histopatologi Meutia, Rena; Razoki, Razoki; Halim, Binarwan; Nasution, Chairul Radjab; Tarigan, Antje Irmella; Fioni, Fioni; Nardi, Leo
Buletin Kedokteran & Kesehatan Prima Vol. 1 No. 2 (2022): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (553.15 KB) | DOI: 10.34012/bkkp.v1i2.2689

Abstract

Tukak lambung merupakan kerusakan jaringan mukosa, sub mukosa sampai lapisan otot lambung. Salah satu penyebabkan tukak lambung yaitu hipersekresi asam lambung sehingga terjadi kerusakan mukosa. Madu memiliki efek gastroprotektif, karena di dalam madu terdapat senyawa flavonoid, vitamin E, asam askorbat, dan katalase, Tujuan penelitian ini adalah untuk mengetahui aktivitas gastroprotektif akibat pemberian madu pada tikus yang diinduksi aspirin. Metode yang digunakan madu pada masing-masing pemberian tunggal diberikan 3 variasi kosentrasi yaitu madu 0,5; 0,75; dan 1 ml/kgbb. Parameter pengamatan meliputi biometrik makroskopis (jumlah tukak, pH tukak dan indeks tukak) dan mikroskopis (uji histopatologi). Bedasarkan hasil yang diperoleh bahwa bedasarkan pengamatan makroskopis terhadap perlakuan tunggal menunjukkan bahwa pemberian madu sebesar 1 ml/kgbb menunjukkan efek gastroprotektif dari kosentrasi lainnya. Kesimpulan: uji histopatologi pada dosis yang memiliki efek gastroprotektif dapat mengembalikan kohesi sel mukosa yang sebelumnya telah rusak akibat erosi.
Detection of glibenclamide adulteration in herbal remedies for diabetes mellitus using TLC Budi, Andre; Razoki, Razoki; Harahap, Halimah; Amansyah, Adek; Edlin, Edlin; Tarigan, Susiani
Buletin Kedokteran & Kesehatan Prima Vol. 3 No. 1 (2024): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v3i1.5287

Abstract

The widespread use of jamu, a traditional Indonesian herbal medicine, has been accompanied by a surge in adulteration with synthetic drugs to enhance efficacy and sales. This study aimed to detect the presence of glibenclamide, a common adulterant, in antidiabetic jamu product using TLC. This study employed three herbal medicine samples marketed for lowering blood glucose levels, with glibenclamide BPFI serving as a reference standard. Thin-layer chromatography, employing a mobile phase consisting of chloroform, cyclohexane, ethanol, and glacial acetic acid (9:9:1:1), was utilized for the analysis. Thin-layer chromatography (TLC) analysis revealed a standard Rf value of 0.4 for glibenclamide, producing a distinct blue-violet spot when visualized with 10% sulfuric acid. The results indicated that the tested herbal medicine samples did not contain the pharmaceutical substance glibenclamide. This conclusion was drawn from the absence of a corresponding Rf value for glibenclamide in the herbal samples when compared to the reference standard.
Mikroenkapsulasi atenolol dengan penyalut hidroksipropil metilselulosa (HPMC) menggunakan metode emulsifikasi penguapan pelarut Neswita, Elfia; Razoki, Razoki; Tanjung, Fahrul Azmi; Novita, Cut Elvira; Sinaga, Ade Putra Fratama; Samin, Buter
Jurnal Prima Medika Sains Vol. 4 No. 1 (2022): Juni
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v4i1.2261

Abstract

Tujuan utama dari penelitian ini adalah memformulasi mikroenkapsulasi atenolol dengan penyalut HPMC menggunakan metode emulsifikasi penguapan pelarut. Dalan metode ini, HPMC dilarutkan dalam pelarut campuran methanol-diklorometana. Sedangkan atenolol dilarutkan ke dalam larutan HPMC. Dalam gelas lain dimasukkan paraffin cair. Hasil penelitian menunjukkan rasio atenolol dan HPMC adalah 1:0,5; 1:1; dan 1:1,5 berturut-turut untuk masing-masing Formula (Formula I, II, III dan IV). Mikroenkapsulasi yang dihasilkan dievaluasi berdasarkan distribusi ukuran partikel dan senyawa aktif yang dilepaskan. Mikrokapsul memiliki distribusi ukuran partikel antara 212-2000 µm. Spektrofotmeter UV dalam metanol yang digunakan untuk mengukur konsentrasi senyawa aktif diperoleh 56,963 ± 17,589; 60,41 ± 1,0045; 60 dan 173 ± 1,0160 % untuk masing-masing Formula (Formula I, II, dan III). Dapat disimpulkan bahwa mikrokapsul dengan perbandingan atenolol dan HPMC 1:1,5 memiliki pelepasan zat aktif yang lebih baik. Kinetika atenolol yang dilepaskan dari mikrokapsul mengikuti persamaan Higuchi.
Antibiotics self-medication practices among students in Universitas Prima Indonesia Novriani, Erida; Neswita, Elfia; Razoki, Razoki
Jurnal Prima Medika Sains Vol. 5 No. 2 (2023): December
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v5i2.4622

Abstract

The irrational use of antibiotics can endanger health by causing unwanted drug reactions, side effects, and drug resistance. This study aimed to analyze the patterns of antibiotic self-medication among university students. This descriptive cross-sectional study was conducted at Prima Indonesia University in October 2023. A total of 307 randomly selected students from various faculties (health science clumps and non-health science clumps) filled out questionnaires distributed via Google Forms. The collected data are then analyzed descriptively to obtain frequency and percentage data, which are then presented in the form of tables and narratives. The results showed that about 83.39% of respondents had used antibiotics before. Most respondents used antibiotics because they were easily available (43.36%) or because of their previous experience (36.72%). The most common conditions for antibiotic use were cough and cold (47.66%), and infections (23.05%). Most respondents used antibiotics based on doctor ’sor pharmacist’s recommendations (45.31%). The duration of antibiotic use was 1-3 days (61.72%), followed by 4-7 days (31.64%) and more than 7 days (6.64%). Antibiotics were purchased from pharmacies (83.20%). The most common reactions to the overuse of antibiotics were nausea and vomiting (40.23%) and headache (32.81%). Most respondents (53.13%) consulted a doctor or pharmacist if they experienced reactions to antibiotic overuse.
Antibacterial test of secondary metabolites of Rhizosphere bacterial isolates of cat whisker against Escherichia coli and Staphylococcus aureus Septia, Evianti Dwi; Hutauruk, Rico Halim; Razoki, Razoki; Piska, Finna
Jurnal Prima Medika Sains Vol. 6 No. 2 (2024): December
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v6i2.5544

Abstract

The rhizosphere is the zone between the root surface and soil. Rhizosphere bacteria can produce metabolites that are antibacterial because they produce phytotherapeutic compounds that have the same properties as those produced by the plant. The purpose of this study was to isolate secondary metabolite compounds from the rhizosphere bacteria of cats’ whisker plants (Orthosiphon stamineus) as antibacterial agents against Escherichia coli and Staphylococcus aureus. This study began with the isolation of rhizosphere bacteria, purification, bacterial characterization, bacterial fermentation, and antibacterial tests. The results of the isolation of Orthosiphon stamineus rhizosphere bacteria obtained as many as six isolates, with each isolate coded as RKK-1, RKK-2, RKK-3, RKK-4, RKK-5, and RKK-6. The results showed that RKK-5 had an inhibition zone against Escherichia coli with a diameter of 8.5 mm. Based on these results, it can be concluded that RKK-5 has a moderate response to Escherichia coli.
Potensi Antihiperglikemia Kombinasi Ekstrak Daun Salam dan Ikan Gabus Razoki, Razoki; Simanjuntak, Nerly Juli Pranita
Jurnal Indah Sains dan Klinis Vol 5 No 3 (2024): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v5i3.04

Abstract

Background: Flavonoids, as secondary metabolites found in bay leaves, exhibit antioxidant properties that help prevent damage to pancreatic β cells by neutralizing free radicals responsible for cell injury. Protein from snakehead fish plays a role in regulating blood sugar levels by inhibiting the α-glucosidase enzyme. Objective: This study aimed to assess the potential of combining the two extracts to lower blood sugar levels in mice. Method: Six groups were used in the study, each receiving a 250 mg/kg BW dose and 40% glucose inducer: Aquades (A), ethanol extract of bay leaves (EEDS), snakehead fish extract (EIG), and combinations of ethanol extracts of bay leaves and snakehead fish (EEDS-IG) in ratios of 1:1, 2:1, and 3:1 (w/w). Results: The study revealed that EEDS and EIG reduced blood sugar levels by 12.14%, 66.9%, 55.0%, 69.3%, 69.7%, and 69.3% at the 120th minute, respectively, for each group. Conclusion: The combination of EEDS and EIG has the potential to reduce blood sugar levels, particularly at a 2:1 ratio
Pengaruh Konseling Obat Terhadap Pengetahuan dan Sikap Pasien Kolestrol di Rawat Jalan RS Advent Medan br. Silalahi, Aancel; br. Sembiring, Novitaria; Hanjaya, Hanjaya; Razoki, Razoki; Neswita, Elfia
Ranah Research : Journal of Multidisciplinary Research and Development Vol. 6 No. 5 (2024): Ranah Research : Journal Of Multidisciplinary Research and Development (Juli 20
Publisher : Dinasti Research

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Counseling is a practice that is needed by pharmacists because it provides significant benefits to patients. One of the important pharmaceutical services is counseling. Counseling, which comes from the word "advice," refers to the process of giving advice, interacting in discussions, and exchanging opinions. Good understanding and increased compliance will contribute to the achievement of the patient's treatment goals. Based on a study conducted on patients with cholesterol disease at Medan Adventist Hospital, data was obtained prospectively through the use of pretest and posttest questionnaires. The total number of participants analyzed was 50 people. To analyze the data using a simple linear regression method, as well as conduct validity and reliability tests. In addition, the paired t-test and the crosstab chi square test were also applied to evaluate the relationship between the characteristics and the research. Based on the results of the analysis of respondent characteristic data, it is known that there are 32% or 16 male respondents and 68% or 34 female respondents. This shows that the majority of respondents are women.
The impact of white turmeric rhizome extract on the histopathological characteristics of the pancreas in male wistar rats with diabetes Lubis, Zahra Khairunnisa; Ongko, Nicolas Xavier; Soekardi, Adi; Razoki, Razoki
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 1 (2025): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i1.6407

Abstract

This study investigates the potential of white turmeric (Curcuma zedoaria Rosc.) rhizome extract as a cost-effective treatment for managing diabetes, focusing on its impact on pancreatic histopathology and blood glucose levels in diabetic Wistar rats. The research employed a randomized pre-test and post-test control group design, with rats induced with alloxan to simulate diabetes. The treatment groups received varying doses of white turmeric extract (250 mg/kg BW, 500 mg/kg BW, and 750 mg/kg BW) for 14 days. Histopathological analysis of the pancreas revealed that the white turmeric extract groups showed no signs of edema, inflammation, or necrosis, indicating a protective effect. Blood glucose level measurements demonstrated that the 500 mg/kg BW dose exhibited the most optimal results in lowering blood glucose levels. Statistical analysis using ANOVA and Kruskal-Wallis tests indicated significant differences between groups. These findings suggest that white turmeric extract, particularly at a dosage of 500 mg/kg BW, holds promise as a complementary treatment for managing diabetes by improving pancreatic health and reducing blood glucose levels. Further research is warranted to explore the underlying mechanisms and optimize its application.
Investigation of Potential Molecular Targets of Zanthoxylum acanthopodium in Ovarian Cancer Using Network Pharmacology Assessments Wijaya, Johanna Fransiska; Chiuman, Linda; Syahputra, Hariyadi Dharmawan; Kaban, Vera Estefania; Razoki, Razoki; Ginting, Chrismis Novalinda; Iksen, Iksen
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 2 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.268

Abstract

Ovarian cancer is a serious disease that affects the ovaries, and its early detection is challenging due to vague symptoms often dismissed as minor ailments. Currently, natural sources have gained attention for their potential role in anticancer treatment. This study aimed to utilize network pharmacology to explore the potential targets and mechanisms of Zanthoxylum acanthopodium in the treatment of ovarian cancer. This study utilized the KNApSAcK and Swiss Target Prediction to identify active compounds and target genes. Additionally, ovarian cancer-specific target genes were sourced from the GEO database. To identify possible key target genes, the network interaction between protein-protein using the STRING database and visualized them in Cytoscape. Subsequent analysis using Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways enabled us to focus on primary therapeutic targets. Our investigation into Zanthoxylum acanthopodium revealed 10 active compounds that pass Lipinski rule of five and oral bioavailability with acceptable pharmacokinetic profiles, 88 therapeutic targets, and identified 5 hub genes: SRC, CCNB2, MMP9, PTGS2, and PTPRC, which are strongly associated with ovarian cancer progression. Pathway enrichment analysis highlighted several pathways significantly related to the pathogenesis of ovarian cancer. This study elucidates the therapeutic potential and mechanisms of action of Z. acanthopodium as a promising candidate for ovarian cancer treatment. However, further research, including both in vitro and in vivo studies, is necessary to understand its molecular mechanisms comprehensively.
An evaluation of patient satisfaction with pharmaceutical services at Munyang Kute Regional General Hospital Bengimiate, Nuriza; Hartopo, Haqi; Razoki, Razoki; Ginting, Astriani Natalia Br
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 2 (2025): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i2.7173

Abstract

Patient satisfaction is a crucial indicator for assessing hospital service quality, in which pharmaceutical services play a vital role as a primary point of contact with patients. This study aimed to comprehensively evaluate the satisfaction level of outpatients with the pharmaceutical services at Munyang Kute Regional General Hospital. This research employed a descriptive quantitative design with a cross-sectional approach. A total of 90 respondents were selected through a purposive sampling technique based on predetermined criteria. The research instrument was an adapted questionnaire designed to measure satisfaction across five dimensions of service quality: tangibles, reliability, responsiveness, assurance, and empathy. The collected data were analyzed descriptively using SPSS software. The findings indicated that patients were generally satisfied with the pharmaceutical services they received. The highest level of satisfaction was observed in the responsiveness dimension, with a percentage of 69.72%. The other dimensions, in descending order, were tangibles (32.21%), empathy (27.19%), assurance (19.60%), and the lowest was the reliability dimension (16.00%). Overall, the patient perception of pharmaceutical services at Munyang Kute Regional General Hospital is positive. Nevertheless, there remains room for improvement, particularly in the reliability and assurance dimensions. Continuous quality improvement through enhanced patient education and optimization of facilities is highly recommended.
Co-Authors Adek Amansyah Ana Fiske Hotmaida Simanjuntak Arbita Huri Astriani Natalia Br Ginting Bengimiate, Nuriza Binarwan Halim br. Sembiring, Novitaria br. Silalahi, Aancel Budi, Andre Chiuman, Linda Edlin, Edlin Elvi Sasmi Erida Novriani Fioni Fioni Fioni, Fioni Friska Rezki Hasibuan Ginting, Astriani Natalia Br Ginting, Chrismis Novalinda Hanjaya, Hanjaya Harahap, Halimah Hariyadi Dharmawan Syahputra Hartopo, Haqi Hotvera Merianis, Hotvera Hutauruk, Rico Halim Iksen, Iksen Lister, INE Lubis, Zahra Khairunnisa Manao, Merlianasari Masriani . Merianis, Hotvera Meutia, Rena Mutia, Maya Sari Nardi, Leo Nasution, Chairul Radjab Nerly Juli Pranita Simanjuntak Neswita, Elfia Novita, Cut Elvira Novitaria Br Sembiring Novriani, Erida Ongko, Nicolas Xavier Piska, Finna Reh Malem br Karo Roy Indrianto Bangar Siagian Salsabila, Dinda Ayu Samin, Buter Septia, Evianti Dwi Simanjuntak, Nerly Juli Pranita Sinaga, Ade Putra Fratama Sitorus, Christina Berliana Soekardi, Adi Syahputra, Hariyadi Dharmawan Tanjung, Fahrul Azmi Tarigan, Antje Irmella Tarigan, Susiani Vera Estefania Kaban Wijaya, Johanna Fransiska Wilson Kanggaran Yohanes Dewantoro Situmorang