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All Journal Jurnal Riset Kefarmasian Indonesia East Asian Journal of Multidisciplinary Research (EAJMR)
Dilla, Anita Ratna
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Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Nursing Public Health

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Evaluation of Indomethacin Stability Dilla, Anita Ratna; Karneli, Supriyadi
East Asian Journal of Multidisciplinary Research Vol. 3 No. 9 (2024): September 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/eajmr.v3i9.11006

Abstract

Indomethacin is a non-steroidal anti-inflammatory drug (NSAID) that is most often used to treat inflammation and pain due to rheumatic diseases. Forced degradation is carried out to save time in carrying out contamination analysis on pharmaceutical preparations. Forced degradation is carried out by providing extreme exposure conditions. The aim of this research is to determine whether indomethacin is stable under various degradation conditions such as acid, base, oxidation, photolysis and temperature. The HPLC method is the main choice because it can simultaneously separate compounds, identify compounds and measure concentrations. The mobile phase used was formic acid: acetonitrile (55:45), C18 column with a flow rate of 1.5 ml/minute and a wavelength of 240 nm. The results of this research show that the validation of Indomethacin meets the validation requirements which include selectivity, linearity, precision, accuracy, LOD, LOQ, and resilience. Indomethacin stability tests under acidic, alkaline, oxidation, photolysis and temperature conditions found that Indomethacin was unstable under all conditions.
Antibacterial Activity of Ethanol Extract from Green Spinach Leaves (Amaranthus viridis) Against Propionibacterium Acnes Revalina, Alfadhila Dwinanda; Dilla, Anita Ratna; Mukhlis, Andi Zsazsa Rafiatul
Jurnal Riset Kefarmasian Indonesia Vol. 8 No. 1 (2026): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v8i1.932

Abstract

Acne is a common chronic skin disorder among adolescents in Indonesia, with a prevalence of approximately 80–85%, particularly in individuals aged 15–18 years. One of the main microorganisms associated with acne pathogenesis is Propionibacterium acnes. This study aimed to evaluate the antibacterial activity of the ethanol extract of green spinach (Amaranthus viridis) leaves against P. acnes. This experimental study was conducted using a well diffusion method. The green spinach leaf extract was prepared through maceration using 96% ethanol as the extraction solvent. Phytochemical screening was performed to identify the presence of bioactive compounds, and antibacterial activity was assessed at extract concentrations of 50%, 60%, and 70%, with clindamycin used as a positive control and sterile distilled water as a negative control. The phytochemical screening results showed that the ethanol extract contained flavonoids, tannins, and saponins. However, the antibacterial assay demonstrated that the extract at all tested concentrations did not produce inhibition zones against P. acnes. In contrast, clindamycin produced a clear inhibition zone with a diameter of 19.25 mm, while the negative control showed no inhibitory effect. These findings indicate that, under the experimental conditions applied in this study, the ethanol extract of green spinach leaves does not exhibit antibacterial activity against P. acnes. Further investigations using higher extract concentrations, alternative extraction methods, or different solvents are necessary to explore the potential antibacterial properties of green spinach leaves more comprehensively.
Co-Authors Karneli, Supriyadi Mukhlis, Andi Zsazsa Rafiatul Revalina, Alfadhila Dwinanda