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All Journal Jurnal Riset Kefarmasian Indonesia Sinteza
Mukhlis, Andi Zsazsa Rafiatul
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Uji Aktivitas Antibakteri Ekstrak Etanol Daun Bintaro (Cerbera odollam) dalam Menghambat Pertumbuhan Streptococcus mutans dan Escherichia coli Mahdi, Nur; Susanti, Susi; Agustina, Ani; Mukhlis, Andi Zsazsa Rafiatul
Sinteza Vol. 4 No. 1 (2024): February
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v4i1.21431

Abstract

Tanaman bintaro (Cerbera odollam) salah satu dari banyak tanaman antimikroba yang ditemukan di Indonesia. Tanaman bintaro efektif dalam mengendalikan serangan hama, namun dalam penelitian antibakteri belum banyak diteliti. Penelitian ini bertujuan untuk menguji aktivitas antibakteri ekstrak etanol daun bintaro menghambat pertumbuhan bakteri Streptococcus mutans dan Escherichia coli. Penelitian ini menggunakan metode eksperimental untuk menguji aktivitas antibakteri menggunakan metode difusi cakram. Pengujian dilakukan dengan menggunakan konsentrasi ekstrak daun bintaro terdiri dari 25%, 50%, 75%, dan 100%, kemudian dilanjutkan dengan analisis data menggunakan uji Kruskal Wallis dan uji Chi Square. Hasil penelitian menunjukkan bahwa ekstrak etanol daun bintaro memiliki sifat antibakteri. Pada konsentrasi ekstrak 75% terhadap Streptococcus mutans diperoleh rata-rata zona hambat sebesar 6,125 mm dengan kategori daya hambat sedang dan pada Escherichia coli diperoleh rata-rata zona hambat sebesar 6,5mm. Kemudian pada pada konsentrasi 100% diperoleh pada kedua bakteri tersebut dengan zona hambat 7,5 mm dengan kategori daya hambat sedang. Uji Kruskal Wallis diperoleh nilai signifikansi sebesar 0,003 atau (p < 0,05) menunjukkan perbedaan bermakna. Uji Chi Square menunjukkan nilai signifikansi untuk Streptococcus mutans sebesar 0,433 atau (p < 0,05) dan Escherichia coli sebesar 0,433 atau (p < 0,05). Pada konsentrasi 100% diameter zona hambat 7,5 mm, hasil ekstrak etanol daun bintaro menunjukkan aktivitas antibakteri dengan kategori sedang terhadap bakteri Streptococcus mutans dan Escherichia coli.
Antibacterial Activity of Ethanol Extract from Green Spinach Leaves (Amaranthus viridis) Against Propionibacterium Acnes Revalina, Alfadhila Dwinanda; Dilla, Anita Ratna; Mukhlis, Andi Zsazsa Rafiatul
Jurnal Riset Kefarmasian Indonesia Vol. 8 No. 1 (2026): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v8i1.932

Abstract

Acne is a common chronic skin disorder among adolescents in Indonesia, with a prevalence of approximately 80–85%, particularly in individuals aged 15–18 years. One of the main microorganisms associated with acne pathogenesis is Propionibacterium acnes. This study aimed to evaluate the antibacterial activity of the ethanol extract of green spinach (Amaranthus viridis) leaves against P. acnes. This experimental study was conducted using a well diffusion method. The green spinach leaf extract was prepared through maceration using 96% ethanol as the extraction solvent. Phytochemical screening was performed to identify the presence of bioactive compounds, and antibacterial activity was assessed at extract concentrations of 50%, 60%, and 70%, with clindamycin used as a positive control and sterile distilled water as a negative control. The phytochemical screening results showed that the ethanol extract contained flavonoids, tannins, and saponins. However, the antibacterial assay demonstrated that the extract at all tested concentrations did not produce inhibition zones against P. acnes. In contrast, clindamycin produced a clear inhibition zone with a diameter of 19.25 mm, while the negative control showed no inhibitory effect. These findings indicate that, under the experimental conditions applied in this study, the ethanol extract of green spinach leaves does not exhibit antibacterial activity against P. acnes. Further investigations using higher extract concentrations, alternative extraction methods, or different solvents are necessary to explore the potential antibacterial properties of green spinach leaves more comprehensively.
Co-Authors Agustina, Ani Dilla, Anita Ratna Nur Mahdi Revalina, Alfadhila Dwinanda Susi Susanti