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Fu’adah, Intan Tsamrotul
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Chemistry Medicine & Pharmacology

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Formulation of Nutraceutical Dosage Form Cempedak Leaves (Artocarpus integer (Thunb.) Merr) Cereal as Immunity Booster for Children Esadini, Aya Rana; Aulia, Gina; Fu’adah, Intan Tsamrotul
Jurnal Kefarmasian Indonesia VOLUME 14, NUMBER 1, FEBRUARY 2024
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Cempedak (Artacorpus integer (Thunb.) Merr) is a plant whose fruit is commonly consumed by the public. However, the leaves are still not widely used and have been reported to have various benefits as efficacious herbal medicines. This is due to its phenolic compounds which play a role in counteracting free radicals and indirectly positively impact the body's immunity. This study aims to formulate cempedak leaf cereal as a new nutraceutical for children. The stages carried out include making extracts, cereal formulations, and evaluating the characteristics of cempedak leaves cereal including organoleptic, specific gravity, compressibility index, flow rate, granule repose angle, moisture content, reconstitution time, organoleptic and pH tests after reconstitution, sedimentation volume, and physical stability test. The formulations were three variations, namely F1 (containing 1% extract), F2 (containing 3% extract), and F3 (containing 5% extract) in the form of granules using wet granulation methods. The formulation and evaluation results of the three formulations are not much different from one another. However, based on the results of the compressibility index, F2 met the good standard criteria, namely 9.23%. The aroma and taste of the formulation are the same as commercial cereals, so we are sure that children will like them. In addition, the results of phytochemical tests also showed that the secondary metabolites contained in cempedak leaf extract could act as immune boosters. The three formulations also showed good stability for 30 days. Based on the results, our formulation met the criteria as nutraceuticals.
Comparison of Indonesian Herbal Drinks Empon-empon and Wedang Pokak for Vitamin C Content and Antioxidant Activity Hasanah, Nur; Utami, Sheila Meitania; Fu’adah, Intan Tsamrotul; Pomalingo, Dwina Ramadhani; Satria, Beny Maulana; Santoso, Pugoh; Tulandi, Silvester Maximus; Ismail, Ayu Indayanti
Jurnal Kefarmasian Indonesia VOLUME 15, NUMBER 2, JULY-DECEMBER 2025
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Empon-Empon and Wedang Pokak are traditional Indonesian herbal drinks prepared from various spices through a simple production process. Empon-Empon consists of red ginger, turmeric, nutmeg, aromatic ginger, bay leaves, lemongrass, galangal, cinnamon, and cloves. At the same time, Wedang Pokak contains red ginger, cloves, lemongrass, cinnamon, cardamom, pandan leaves, and star anise. Both drinks are widely recognized as sources of antioxidants and vitamin C, and are believed to strengthen the immune system. This study aimed to determine the vitamin C content and antioxidant activity of Empon-Empon and Wedang Pokak. Vitamin C analysis was carried out using UV-Vis spectrophotometry, which showed a maximum wavelength at 245 nm with a linear regression equation y = 0.0434x – 0.0967 (R² = 0.9942). The vitamin C content was 23.33 µg/mL (0.233%) in Empon-Empon and 20.28 µg/mL (0.202%) in Wedang Pokak. Antioxidant activity was determined using the DPPH method, yielding inhibition percentages of 21.28% (20 µg/mL), 40.16% (40 µg/mL), 46.48% (60 µg/mL), and 59.67% (80 µg/mL) for Wedang Pokak, with an IC₅₀ value of 63.33 µg/mL. This activity was lower than Empon-Empon (IC₅₀ 40.53 µg/mL) and pure vitamin C (IC₅₀ 3.77 µg/mL). In conclusion, Empon-Empon exhibited higher vitamin C content and stronger antioxidant activity than Wedang Pokak, highlighting its potential as a functional drink to support health.
Co-Authors Aulia, Gina Ayu Indayanti Ismail Beny Maulana Satria Esadini, Aya Rana Nur Hasanah Pomalingo, Dwina Ramadhani Santoso, Pugoh Sheila Meitania Utami Silvester Maximus Tulandi