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All Journal Journal of Bioresources and Environmental Sciences Biosaintifika: Journal of Biology & Biology Education
Astari, Putri Dyah
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Agriculture, Biological Sciences & Forestry Earth & Planetary Sciences Environmental Science

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Pharmacokinetics Profile of Chitosan Nanoparticles in Chronic Lead-induced Toxicity Rats Model Marianti, Aditya; Amalina, Nur Dina; Mursiti, Sri; Sitompul, Faya Nuralda; Futri, Shafira Septiana; Negara, Legendra Gantar; Sholehah, Intan Kharyna; Asmorowati, Dian Sri; Astari, Putri Dyah
Biosaintifika: Journal of Biology & Biology Education Vol. 16 No. 1 (2024): April 2024
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/biosaintifika.v15i1.1857

Abstract

Chronic lead exposure induces ROS accumulation which causes physiological disorders. Chelation therapy has been widely used to overcome lead poisoning since it exerts only a few side effects. Nano chitosan prevents lead poisoning by inhibiting ROS. This study examined the pharmacokinetics of nano chitosan in chronic lead-induced toxicity animal models and the mechanism of action pathway using the bioinformatic approach, The area under the curve was estimated to be 12110.13 ± 7709.37 μg/mL hours using the pharmacokinetic model, and the Cmax was 82.34 ± 5.64 μg/mL. The Tmax and t½ calculations were 22.68 ± 11.67 and 80.47 ± 60.58 hours respectively. Chitosan nanoparticles regulated VEGFA, FGF2, and LGALS3 which plausibly played a substantial role in chronic lead exposure. However, chitosan is not suitable for oral administration due to its low gastrointestinal solubility. These characteristics make chitosan nanoparticles have the prospect of being developed as a supplement so that they can contribute to overcoming the negative impacts of chronic lead poisoning.
The development of ozone-filtration using green mussels shells for laundry wastewater treatment Ichlasia, Amira Liontina; Althafunnisa, Azzahra Shakayla; Sheridia, Cheryl; Nugroho, Kinanthy Ayudia Putri; Adelia, Zameera; Ulya, Himmatul; Astari, Putri Dyah; Baihaqi, Rifqi Ahmad
Journal of Bioresources and Environmental Sciences Vol 4, No 1 (2025): April 2025
Publisher : BIORE Scientia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61435/jbes.2025.19956

Abstract

This study explores the potential of green mussel shells as a filtration medium for treating laundry wastewater. The research evaluated the effects of ozonation as a pre-treatment step and compared two filtration reactors, reactor one (R1) without green mussel shells and reactor two (R2) using green mussel shells. In this filtration system, hydrostatic force is used due to its reliability in determining the pressure difference between the upstream and downstream sides of the reactors. Treated wastewater samples were collected every 5 minutes to be analyzed. Several important water quality parameters are monitored, including pH, chemical oxygen demand (COD), and dissolved oxygen (DO). The odor and color of the laundry wastewater were also observed. Results showed the effectiveness of green mussel shells in improving wastewater quality, particularly in neutralizing pH, reducing COD, and increasing DO. The results of linear regression calculations showed that in R2, the pH decreased by around 26%, the COD concentration decreased by 76%, and the greater increase in DO was 118% from the concentration without treatment. This research showed that green mussel shells in R2 have the potential to be used as a filtration element to treat laundry wastewater as a sustainable solution, addressing both environmental pollution and water quality challenges.  
Co-Authors Adelia, Zameera Aditya Marianti Althafunnisa, Azzahra Shakayla Amalina, Nur Dina Baihaqi, Rifqi Ahmad Dian Sri Asmorowati Futri, Shafira Septiana Himmatul Ulya Ichlasia, Amira Liontina Negara, Legendra Gantar Nugroho, Kinanthy Ayudia Putri S Mursiti Sheridia, Cheryl Sholehah, Intan Kharyna Sitompul, Faya Nuralda