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All Journal Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Ilmiah Manuntung Martabe : Jurnal Pengabdian Kepada Masyarakat JPPM (Jurnal Pengabdian dan Pemberdayaan Masyarakat) Jurnal Mandala Pharmacon Indonesia Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Ilmiah Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian Bencoolen Journal of Pharmacy Kartika : Jurnal Ilmiah Farmasi Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Nurfijrin Ramadhani, Nurfijrin
Program Studi S1 Farmasi, Fakultas MIPA, Universitas Bengkulu
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences

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Journal : Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan

 1 
UJI EFEKTIVITAS ANTIHIPERGLIKEMIA INFUSA ALGA LAUT COKLAT (Sargassum hystrix) PADA MENCIT JANTAN DENGAN METODE TOLERANSI GLUKOSA Samudra, Agung Giri; Ramadhani, Nurfijrin; Utami, Cyntia Dwi; Wirahmi, Nori; Sani K, Fathnur
Jurnal Ilmiah Manuntung Vol 7 No 2 (2021): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v7i2.510

Abstract

One type of metabolic disease that is always experiencing an increase in sufferers every year in countries around the world is diabetes mellitus. Sargassum hystrix marine algae are the types that are found and quite abundant in Indonesia. This study aims to prove the hypoglycemic effect of Sargassum hystrix infusion in male white mice. The study was conducted using the oral glucose test method in the positive control group (I) given glibenclamide 0.52mg / 20gramBB; group (II) is a negative control given CMC Na 0.5%; group (III) infusion of Sargassum hystrix with a concentration of 2.5% with a volume of 0.2 mL / 20gram BW; group (IV) infusion of Sargassum hystrix with a concentration of 5% by volume of 0.2 mL / 20gram BW. The results were analyzed using One Way Anova which was then followed by Duncan's test. The results showed that Sargassum hystrix infusion had an antihyperglycemic effect (p <0.05) when compared with negative controls. Sargassum hystrix 5% infusion is the best dose with the antihyperglycemic effect statistically the same as the antihyperglycemic effect of glibenclamide.
FORMULASI NANOPARTIKEL KITOSAN EKSTRAK METANOL ALGA LAUT COKLAT (Sargassum hystrix) DENGAN METODE GELASI IONIK Samudra, Agung Giri; Ramadhani, Nurfijrin; Sani K, Fathnur; Lestari, Gina; Nugroho, Bambang Hernawan
Jurnal Ilmiah Manuntung Vol 7 No 1 (2021): Jurnal Ilmiah Manuntung
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v7i1.428

Abstract

The content of marine algae Sargassum hystrix includes polysaccharides (alginates), polyphenols, proteins, peptides, amino acids, lipids, minerals, and several vitamins. However, the use of natural ingredients has limitations, namely that it often fails in the clinical phase due to low bioavailability. One effort that can be done to overcome this problem is to formulate nanoparticles using chitosan polymer and sodium tri-polyphosphate. This study aims to formulate nanoparticles from the methanol extract of Sargassum hystrix with various chitosan concentration ratios. The methanol extract of Sargassum hystrix was obtained by extraction using the maceration method with 50% methanol as a solvent. The results of the extract were made colloidal nanoparticles using ionic gelation techniques using a variation of the methanol extract of Sargassum hystrix: chitosan: NaTPP: Tween 80, Formulation 1 (0.75 gram: 0.1% 18 mL: 0.1% 9 mL: 0.5% 3 mL); Formulation 2 (0.75 gram: 0.2% 18 mL: 0.2% 9 mL: 0.5% 3 mL); Formulation 3 (0.75 gram: 0.1% 18 mL: 0.2% 9 mL: 0.5% 3 mL); Formulation 4 (0.75 gram: 0.2% 18 mL: 0.1% 9 mL: 0.5% 3 mL). The nanoparticle colloids formed were characterized by particle size (nm), and the zeta potential (mV), Formula 1 (212.65 ± 45.32; -11.4 ± 5.65), Formula 2 (514.55 ± 56.35; -8.85 ± 1.34), Formula 3 (219.35 ± 43.76; -14.5 ± 1.83), Formula 4 (326.5 ± 3.39; -1.25 ± 17.88). All formulas show that they can form nanoparticle formulas between 1-1000 nm., But the preparation that will be more stable is formula 3 because it has a zeta potential that is close to +/- 30 mV.
Co-Authors Adi Jaza Fajar Utama Agung Giri Samudra Agung Giri Samudra Anjani Chintya Pratiwi Annisa Muslimah Apriza Hongko Putra Armando, Jimmy Bambang Hernawan Nugroho Bambang Hernawan Nugroho, Bambang Hernawan Cyntia Dwi Utami Delia Komala Sari Febriyani, Ulfa Gatot Prasetya Gina Lestari, Gina herlina herlina Juwita Sartati Lea Wati Indah Pratiwi nurwani purnama aji Pratiwi, Rina Septi Reza Pertiwi Rina Septi Pratiwi Sani K, Fathnur Suci Rahmawati Thesa Monica Tiara Feni Lestari Triyana Yestira Ulvi Ditasari Utami, Cyntia Dwi Wafa Syahidah Wahyu Alamsyah Wirahmi, Nori Yuska Novianti