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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Livestock and Animal Research
Endang Mahati
Diponegoro University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Veterinary

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Experimental animal models for polycystic ovarian syndrome (methods, effects, and implications) Erna Yovi Kurniawati; Noor Pramono; Syarief Thaufik Hidayat; Endang Mahati
Livestock and Animal Research Vol 22, No 1 (2024): Livestock and Animal Research
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/lar.v22i1.79197

Abstract

Many studies have replicated the clinical and genetic features of polycystic ovarian syndrome (PCOS) using a range of experimental animal models to improve treatment outcomes. This article aims to present an overview of the various experimental animal models that have been used in PCOS research. In this study, we conducted a systematic review of relevant research articles on the induced animal model PCOS. We searched research articles in Indonesian and English published over the last five years through three databases: PubMed, ScienceDirect, Google Scholar. We use established inclusion and exclusion criteria to select suitable articles. Out of 19 research articles included in our systematic review, we found the animal model PCOS based Rotterdam criteria, PCOS-IR model, PCOS-Inflammation model, PCOS-Gut microbiota model and PCOS-syndrome metabolic model. Androgen agents such as testosterone propionate, free testosterone, DHEA, and letrozole, as well as sodium valproate, are effective in the induction of PCOS phenotypes based on the Rotterdam criteria (oligo/amenorrhea, hyperandrogenic, and polycystic ovaries).
THE EFFECT OF GREEN TEA AND STEVIA EXTRACT ON LIVER HISTOPATHOLOGY WISTAR RATs TYPE II DIABETES MELLITUS Elmawati Novit; Udadi Sadhana; Endang Mahati
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol. 12 No. 1 (2021): June 2021
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v12i1.7437

Abstract

Introduction: Glucose metabolism abnormality on type 2 diabetes mellitus (T2DM) caused liver damage due to dyslipidemia and increasing oxidative stress. Antidiabetic and antioxidants within green tea leaf and stevia leaf extract prevent liver damage due to T2DM complications. Objective: To investigate green tea and stevia leaf extract effects on liver histopathology on T2DM rats.Methods: This study used Post Test Only Control Group Design. A total of 30 Wistar rats were divided into 5 groups: control group (C-G), normal rats; negative control group (NC-G), T2DM induction; positive control group (PC-G), treated by Metformin; the first treatment group (T1-G), was treated by green tea leaf extract and stevia leaf extract; and the second treatment group (T2-G) was treated by a Metformin also green tea and stevia leaf extract. The treatment was given to subjects for 21 days starting 3 days after the induction of Nicotinamide (NA) and Streptozotocine (STZ). Histopathological assessment of liver cells uses assessment parameters in the form of features of necrosis, vacuolization, sinusoidal dilation and number of inflammatory cells. Hypothesis will be tested by Kruskal-Wallis (p<0,05) dan Mann-Whitney test (P<0,05) Results: The difference of liver damage in all group shows a significant difference, p<0.05. Significant differences in liver damage scores between the 2 groups there are between the negative control group and the control group (0.031), positive control (0.042), and second treatment group (0.011), and between first treatment group and second treatment group (0.041).Conclusion: The administration of green tea extract, stevia leaf, and standard drug may reduce liver damage score of Wistar with T2DM
Co-Authors Elmawati Novit Kurniawati, Erna Yovi Noor Pramono Syarief Thaufik Hidayat Udadi Sadhana