Article Per Year (5 Year)
p-Index From 2021 - 2026
0.444
P-Index
This Author published in this journals
All Journal Jurnal Pengabdian Masyarakat AbdiMas Current Research on Biosciences and Biotechnology
Nadiya Nurul Afifah
Universitas Esa Unggul
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Education Materials Science & Nanotechnology Medicine & Pharmacology

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
ERCC2 rs13181 and ERCC1 rs11615 polymorphisms in non-small cell lung cancer patients in West Java: towards personalized medicine approaches Afifah, Nadiya Nurul; Effendi, M. Fariz; Diantini, Ajeng; Barliana, Melisa Intan; Intania, Ruri
Current Research on Biosciences and Biotechnology Vol. 6 No. 2 (2025)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/crbb.2025.6.2/3DCBQ451

Abstract

Non-Small Cell Lung Cancer (NSCLC) is a disease with a high incidence rate, low survival due to late diagnosis and treatment delays, and varying effectiveness of platinum-based chemotherapy. Individual responses to platinum-based chemotherapy are influenced by genetic polymorphisms in genes affecting pharmacokinetic and pharmacodynamic mechanisms. This study focuses on identifying polymorphisms in the ERCC2 and ERCC1 genes, which play a role in platinum pharmacodynamics, and their effects on chemotherapy response. The study involved 23 NSCLC patients conducted at Dr. H.A. Rotinsulu Lung Hospital in Bandung. Polymorphism data were obtained through genotype analysis using sequencing methods from prospective whole blood samples of patients, while chemotherapy effectiveness was assessed by evaluating chemotherapy response using the RECIST 1.1 method, and radiological response prediction and prognostic factors were determined through CYFRA 21-1 levels. The results showed an OR of 0.964 (95% CI: 0.160 - 5.795) for ERCC2 rs13181 CC + AC vs. AA against chemotherapy response evaluation by RECIST 1.1, and 0.722 (95% CI: 0.062 - 8.464) against CYFRA 21-1 values. Meanwhile, for ERCC1 rs11615, an OR of 0.268 (95% CI: 0.046 - 1.548) CT + TT vs. CC for RECIST 1.1 and 0.3 (95% CI: 0.026 - 3.427) for CYFRA 21-1 values were obtained. In clinical interpretation, it is known that variant alleles at rs13181 and rs11615 have potential for better chemotherapy response although not statistically significant (p>0.05), these results can be considered when assessing patient response to chemotherapy within six cycles. This study provides initial data and forms the basis for future comprehensive cohort observational research.
PENINGKATAN LITERASI HIPERTENSI MELALUI EDUKASI TIGA PILAR: PATOFISIOLOGI, GAYA HIDUP SEHAT, DAN FARMASI (DAGUSIBU) PADA KOMUNITAS POSBINDU KEBON JERUK Abna, Inherni Marti; Pradana, Reinaldo; Afifah, Nadiya Nurul; Eff, Aprilita Rina Yanti
Jurnal Pengabdian Masyarakat AbdiMas Vol 12, No 3 (2026): Jurnal Pengabdian Masyarakat Abdimas
Publisher : Universitas Esa Unggul

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47007/abd.v12i3.10612

Abstract

AbstractHypertension (HT) is a major risk factor for Cardiovascular Disease (CVD) in Indonesia, characterized by high prevalence, with most cases remaining uncontrolled. This condition necessitates a multidisciplinary approach focused on enhancing health literacy and treatment adherence. The objective of this community service program was to improve health literacy related to HT prevention and management. The activity was conducted on July 2, 2025, at RPTRA Jeruk Manis, involving 35 participants (PKK mothers, Dasawisma representatives, and Posbindu cadres). The intervention utilized structured interactive counseling delivered through three core pillars: Pathophysiology, Healthy Lifestyle, and Pharmaceutical Education (DAGUSIBU). Effectiveness was measured using a 10-item multiple-choice post-test and blood pressure screening. The results showed high success in the cognitive domain, evidenced by post-test scores predominantly ranging from 80 to 100. Significant improvement in understanding occurred regarding risk concepts, non-pharmacological strategies (salt restriction), and medication adherence. Clinically, early detection successfully identified several cases of clinical hypertension and pre-hypertension among participants, confirming the program's urgency and relevance. The three-pillar education model proved effective in enhancing community health literacy concerning hypertension prevention. Continuous follow-up and behavioral monitoring are required to transform the acquired knowledge into sustainable lifestyle changes.Keywords: Hypertension; Health Literacy; Three-Pillar Education; DAGUSIBU; Posbindu. AbstrakHipertensi (HT) merupakan faktor risiko utama Penyakit Kardiovaskular (PKV) di Indonesia, dengan prevalensi tinggi yang sebagian besar tidak terkontrol. Kondisi ini menuntut pendekatan multidisiplin yang berfokus pada peningkatan literasi kesehatan dan kepatuhan pengobatan. Tujuan pengabdian masyarakat ini adalah meningkatkan literasi kesehatan terkait pencegahan dan manajemen HT. Kegiatan dilaksanakan pada 2 Juli 2025 di RPTRA Jeruk Manis dengan melibatkan 35 peserta (ibu-ibu PKK, Dasawisma, dan kader Posbindu). Metode intervensi menggunakan penyuluhan interaktif terstruktur melalui tiga pilar: Patofisiologi, Gaya Hidup Sehat, dan Edukasi Farmasi (DAGUSIBU). Efektivitas diukur melalui post-test 10 soal pilihan ganda dan pemeriksaan tekanan darah. Hasil menunjukkan keberhasilan tinggi di domain kognitif, dibuktikan dengan skor post-test yang dominan di rentang 80 hingga 100. Peningkatan pemahaman yang signifikan terjadi pada konsep risiko, strategi non-farmakologis (pembatasan garam), dan kepatuhan obat. Secara klinis, deteksi dini berhasil menemukan beberapa kasus hipertensi klinis dan pre-hipertensi di antara peserta, menegaskan urgensi dan relevansi program. Edukasi tiga pilar terbukti efektif dalam meningkatkan literasi kesehatan masyarakat terkait pencegahan hipertensi. Diperlukan tindak lanjut dan monitoring perilaku berkelanjutan untuk mentransformasi pengetahuan yang diperoleh menjadi perubahan gaya hidup yang lestari.Kata Kunci: Hipertensi; Literasi Kesehatan; Edukasi Tiga Pilar; DAGUSIBU; Posbindu.
Co-Authors Abna, Inherni Marti Ajeng Diantini, Ajeng Aprilita Rina Yanti Eff Effendi, M. Fariz Intania, Ruri Melisa Intan Barliana, Melisa Intan Reinaldo Pradana