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All Journal FITOFARMAKA: Jurnal Ilmiah Farmasi Unnes Journal of Public Health Majalah Farmasetika Jurnal Pengabdian Masyarakat Indonesia International Journal of Engineering, Science and Information Technology Pharmaceutical Sciences and Research (PSR) Borneo Journal of Pharmacy
Aprilita Rina Yanti Eff
Universitas Esa Unggul
Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Electrical & Electronics Engineering Energy Engineering Industrial & Manufacturing Engineering Library & Information Science Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Physics Public Health Social Sciences Transportation

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Efektivitas Repelan Losion Minyak Atsiri Daun Zodia (Evodia Suaveolens) Terhadap Nyamuk Aedes aegypti Linnaeus Aprilita Rina Yanti Eff; Ratih Dyah Lestari Ayu Pertiwi; Tyas Putri Utami
Majalah Farmasetika Vol. 4, Supl. 1, Tahun 2019
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/mfarmasetika.v4i0.25868

Abstract

Zodia (Evodia suaveolens) merupakan salah satu tanaman yang mempunyai aroma yang tajam pada bagian bunga dan daunnya dan dipercaya dapat mengusir nyamuk. Daun Zodia mengandung minyak atsiri evodiamine dan rutaecarpine yang tidak disukai oleh nyamuk. Tujuan penelitian ini untuk menilai efektivitas repelen losion mengandung minyak atsiri daun Zodia pada konsentrasi 1%, 1.5% dan 2%. Metodenya dengan iosion yang dibuat dengan mencampurkan minyak atsiri hasil isolasi dari daun Zodia pada konsentrasi 1%, 1,5% dan 2% ke dalam formulasi sediaan losion yang terdiri dari asam stearat, setil alkohol, parafin cair, dimetikon, vaselin kuning, trietanolamin dan asam sitrat. Pengujian dilakukan dengan cara memasukkan lengan secara bergantian antara lengan yang diberi perlakuan (losion) dan kontrol (tidak diberi perlakuan) ke dalam kurungan nyamuk yang berisi 25 ekor nyamuk Aedes aegypti, kemudian  dihitung jumlah nyamuk yang hinggap setiap jam selama enam jam. Efikasi repelan ditentukan berdasarkan daya proteksi yang dihitung dengan rumus : Daya proteksi (DP) =( K - R)/K x 100%; K = banyaknya hinggapan pada lengan control; R = banyaknya hinggapan pada lengan pelakuan.  Hasil penelitian losion mengandung minyak atsiri daun zodia pada konsentrasi 1%, 1,5% dan 2% berpotensi sebagai pengusir nyamuk  (repelan) Aedes aegypti dengan daya proteksi rata-rata selama enam jam berturut-turut  adalah sebesar 74,50%, 75,39% dan 82,45%. Tidak terdapat perbedaan yang signifikan pada daya proteksi antara ke 3 konsentrasi losion  (p>0.05) Losion mengandung minyak atsiri daun zodiac pada konsetrasi 1%, 1,5% dan 2% memiliki efektivitas sebagai repelen. Daya proteksi tertinggi ditunjukkan oleh losion yang mengandung minyak atsiri daun Zodia 2% yaitu sebesar 82.45%.
THE ACTIVITY OF GEL EXTRACT MAHKOTA DEWA FRUITS [(Phaleria macrocarpa (Scheff.) Boerl] THROUGH TYROSINASE ENZYME INHIBITOR Aprilita Rina Yanti Eff; Erika Noviyanti; Ratih Dyah Pertiwi
FITOFARMAKA: Jurnal Ilmiah Farmasi Vol 12, No 1 (2022): FITOFARMAKA: Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jf.v12i1.4874

Abstract

Mahkota dewa fruit [(Phaleria macrocarpa (Scheff.) Boerl] contains benzophenone derivatives which have sun protection activity and flavonoid compounds which can act as tyrosinase inhibitors.  This study aimed to determine the tyrosinase inhibitor activity of 70% ethanol extract of Mahkota Dewa fruit and gel extract of Mahkota Dewa fruits with variations in concentrations of 1.25% (F1), 2.5% (F2), and 5% (F3). Assay of tyrosinase inhibitor activity against ethanol extract of Mahkota Dewa fruit and ethanol extract was done with various concentrations (31.25, 62.5, 125, 250, and 500 µg/ml), using a positive control of Kojic acid and L-DOPA as a substrate. Absorbance measurement was carried out using UV-vis microplate reader with a wavelength of 480 nm. The results showed that the ethanolic extract Mahkota Dewa had an IC50 value of 6668.06 µg/ml while kojic acid as a positive control possessed an IC50 value of 4.22 µg/ml. Gel preparation of the ethanol extract has inhibitor activity of the enzyme tyrosinase represent moderate values of the IC50each, i.e., F1 (1.25%) amounted to 285.03 µg/ml, F2 (2.5%) amounted to 373.25µg/ml, and F3 (5%) of 397.40 µg/ml. The tyrosinase inhibitor activity of the 70% ethanol extract of Mahkota Dewa fruit was lower with a relative potency of 5.167 x 10-3 times compared to that of kojic acid.
Upaya Pencegahan Penyakit Sindrom Metabolik Sejak Remaja Aprilita Rina Yanti Eff; Sri Teguh Rahayu; Ayu Puspita Lena
Jurnal Pengabdian Masyarakat Indonesia Vol 2 No 3 (2022): JPMI - Juni 2022
Publisher : CV Infinite Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52436/1.jpmi.612

Abstract

Masa remaja merupakan fase kritis dimana terjadi beberapa perubahan, seperti perubahan fisik, perkembangan otak, maturasi organ seksual, dan perkembangan psikososial yang mempengaruhi perilaku terkait kesehatan. Remaja rentan mengalami permasalahan kesehatan, terutama pada penyakit sindrom metabolik. Hal ini juga didukung apabila gaya hidup masa remaja tidak diperhatikan terutama di masa pandemi seperti sekarang ini, dimana makan yang tidak terkontrol dan jarang melakukan aktivitas fisik sehingga penyakit sindrom metabolik ini semakin rentan terjadi pada usia remaja. Kegiatan Pengabdian Masyarakat dilakukan dengan memberikan edukasi mengenai sindrom metabolik pada 30 siswa siswi kelas IX SMP 264 Jakarat berupa pemberian materi mengenai bagaimana mencegah sindrom metabolik dengan menerapkan pola makan yang sehat, dan aktivitas fisik yang teratur, agar dapat diterapkan dalam kehidupan sehari-hari.  Selain itu dilakukan pula pengukuran berat badan, tinggi badan, tekanan darah, dan lingkar pinggang untuk melihat gambaran kesehatan siswa-siswi SMPN 264 Jakarta. Hasil pengukuran tekanan darah menunjukkan 5 orang siswa memiliki tekanan darah ?130/85 mmHg. Pemberian Edukasi pada 30 siswa siswi kelas IX SMPN 264 Jakarta mengenai bagaimana mencegah sindrom metabolik dengan menerapkan pola makan yang sehat, dan aktivitas fisik yang teratur   sangat penting untuk terus dilakukan sehingga remaja memiliki pengetahuan tentang pentingnya menerapkan pola hidup sehat untuk mencegah sindrom metabolik.
Uji Efek Antiinflamasi Fraksi Air Daun Mahkota Dewa (Phaleria macrocarpa (Shecff.) Boerl.) terhadap Tikus Putih (Rattus norvegicus L.) Eff, Aprilita Rina Yanti; Dewanti, Ema; Adelina H, Melisha
Pharmaceutical Sciences and Research Vol. 1, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Inflammation occurs as the attempt of body to inactivate organisms that attack the body, removing irritants and regulate tissue repair. One of the medicinal plants used empirically as antiinflammation is the leaf of Mahkota Dewa (Phaleria macrocarpa (Schecff.) Boerl). This study investigated the effect of anti-inflammatory water fraction of leaf Mahkota Dewa using oedema induction method with caragenin in rat. Water fraction of Mahkota Dewa was given at the dose 0.5 g/kg BW ,1 g/kg BW and 2 g/kg BW. Sodium diclofenac was used as a positive control and CMC as negative control. The result showed water fractions of three doses can inhibit inflammation at 27.35%, 18.58%, and 20.17%, respectively. The water fraction at the dose 0.5 g/kgBW showed the largest percentage of oedema inhibition compared to other treatment groups.
Antihypertensive and Antioxidant Activity of Herbal Medicine (Jamu) B on Rats Induced by 10% Fructose Eff, Aprilita Rina Yanti; Ayu Pertiwi, Reza; Ehe Hurit, Hermanus; Rahayu, Sri Teguh; Eden, Yonatan
Pharmaceutical Sciences and Research Vol. 9, No. 1
Publisher : UI Scholars Hub

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Abstract

Prolonged fructose intake can activate the renin-angiotensin-aldosterone system and enhance oxidative stress conditions, causing hypertension and hyperuricemia. This study aimed to determine the antihypertensive and antioxidant activity of Jamu B on the activity of superoxide dismutase (SOD), glutathione (GSH), and malondialdehyde (MDA) in the kidneys of Sprague Dawley rats induced by 10% fructose. Thirty rats were divided into six groups. Groups B1-B3 were Jamu groups at a dose of 0.12 g/kg BW (B1), 0.24 g/kg BW (B2), and 0.36 g/kg BW (B3); group C (positive control) was given captopril 0.1 g/kg BW, group D (negative control) was given only 10% fructose, and group E (normal control) was healthy rats. The 10% fructose was induced for eight weeks and the treatment was given at the week 9th and 10th. Jamu B reduced systolic and diastolic blood pressure at all doses, but not significantly different from the normal control group (p>0.05). The SOD activity in groups B1, B2, B3, and C was significantly different from the negative control group (pJamu B at dose of 0.12 g/kg BW; 0.24 g/kg BW; and 0.36 g/kg BW have antihypertensive and antioxidant activity in the kidneys of rats induced by 10% fructose. Nevertheless, Jamu B at a dose of 0.36 g/kg BW was the most effective as an antihypertensive and antioxidant.
Assessment of Drug Therapy Problems Among Type 2 Diabetes Patients with Hypertension Comorbidity in Indonesia Julaeha Julaeha; Ery Fudjiati; Aprilita Rina Yanti Eff
Borneo Journal of Pharmacy Vol. 3 No. 3 (2020): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v3i3.1359

Abstract

Type 2 diabetes mellitus (T2DM) is a major chronic disease that affects a large number of people worldwide. Hypertension is a common disease comorbidity among T2DM patients, and often those patients received polypharmacy and complex treatment in long term duration. This condition may lead to an increased risk of drug therapy problems (DTPs). This study aimed to assess and determine potential drug therapy problems in type 2 diabetic patients with hypertension comorbidity. Retrospective cross-sectional design was conducted in a hospital setting, especially data sources from the prescription of ambulatory T2DM patients with hypertension. A total of 190 patients were studied. More than half of the participants were female (53.68%). The majority age range of participants was 50-59 years (46.84%). Almost all antidiabetic agents were prescribed as polypharmacy (73.16%). Metformin was the most antidiabetic agent prescribed as monotherapy and combination therapy (63.16%). Almost all antihypertensive agents were prescribed as polypharmacy (63.26%). Amlodipine was the most antihypertensive agent prescribed as monotherapy and combination therapy (34.74%). Among the study participants, 56.84% have at least one of DTPs. Adverse drug reaction was the most frequent (47.22%), followed by ineffective drug therapy (29.63%). Since the potential of DTPs in T2DM patients with hypertension comorbidity is relatively high, early identifying, resolving, and preventing drug therapy problems by the pharmacist is needed to achieve goals of treatment.
Pharmacovigilance and Adverse Drug Reaction Reporting by Nurses to Improve Patient Safety Goals at Hospital in Bekasi, West Java Eff, Aprilita Rina Yanti; Utami, Luciana Mery; Indrawati, Ratna
Unnes Journal of Public Health Vol 13 No 1 (2024): Unnes Journal of Public Health
Publisher : Universitas Negeri Semarang (UNNES) in cooperation with Association of Indonesian Public Health Experts (Ikatan Ahli Kesehatan Masyarakat Indonesia (IAKMI))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/ujph.v13i1.72297

Abstract

Nurses are frontline healthcare providers who spend much time with patients and can help avoid, mitigate, promote public health, and determine and maintain medicine safety. To ensure patient and medication safety, nurses need knowledge and experience in Pharmacovigilance. This study aims to assess Pharmacovigilance and adverse drug reaction reporting by nurses to implement Patient Safety Goals with Patient Safety Culture as intervening variables at X Hospital in Bekasi. This research is a quantitative causality study with a cross-sectional design to see the effect of pharmacovigilance knowledge on implementing patient safety goals mediated by patient safety culture. The study was conducted on 130 nurses at X Bekasi Hospital who met the inclusion and exclusion criteria. The data collection technique uses a closed questionnaire instrument; the answers to the questionnaire questions have been determined. Data were analyzed using the Smart PLS program's Structural Equation Modeling technique. The study's results found that knowledge of Pharmacovigilance and adverse drug reactions significantly affected the implementation of patient safety goals (F count is greater than F table / 64.5> 2.67; (R²) = 0.667). There is a significant influence of pharmacovigilance knowledge on improving patient safety culture (p-value = 0.000). The estimated value of the influence of pharmacovigilance knowledge on patient safety culture is 60.9%. Knowledge, attitude, and practice of Pharmacovigilance is the dominant variable in influencing patient safety culture and positively influences the implementation of patient safety goals. However, knowledge, attitude, and practice significantly impact patient safety culture, so efforts to implement consistent and continuous Pharmacovigilance can improve patient safety culture, which will continue with implementing patient safety goals.
Building Collaborative Advantage in Hospital Systems: The Role of Supply Chain Collaboration, Innovation, and Digital Transformation in Class C Hospitals in Java Island Uli, Syahdani; Anindita, Rina; Eff, Aprilita Rina Yanti; Syah, Tantri Yanuar Rahmat
International Journal of Engineering, Science and Information Technology Vol 5, No 4 (2025)
Publisher : Malikussaleh University, Aceh, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52088/ijesty.v5i4.1483

Abstract

This study aims to analyze the influence of transformational leadership, digital transformation, supply chain collaboration, and innovation on collaborative advantage and the performance of type C hospitals in Java, with government subsidies as a moderating variable. Using a quantitative approach and PLS-SEM analysis on 50 hospitals, the results show that most direct relationships between variables are insignificant, except for the influence of innovation on collaborative advantage and the influence of collaborative advantage on hospital performance, which are proven to be significant. In addition, government subsidies only play a significant role in strengthening the relationship between supply chain collaboration and collaborative advantage. These results confirm that collaborative advantage is a key factor in improving hospital performance, with innovation as its main driver. Meanwhile, transformational leadership and digital transformation have not shown a strong direct influence due to bureaucratic limitations and implementation readiness. These findings also indicate that government subsidies are more effective in the early stages of establishing collaborations, rather than directly improving performance. This study highlights the importance of external collaboration strategies and innovation in improving the competitiveness of public hospitals, as well as the importance of adapting global theories to the local context in developing health policies in Indonesia.
Co-Authors Adelina H, Melisha Ayu Pertiwi, Reza Ayu Puspita Lena Eden, Yonatan Ehe Hurit, Hermanus Ema Dewanti Erika Noviyanti Ery Fudjiati Intan Silviana Mustikawati Julaeha Julaeha Mury Kuswari Pertiwi, Ratih Dyah Rachmanida Nuzrina Ratna Indrawati, Ratna Rian Adi Pamungkas Rina Anindita Rosya, Ernalinda Sri Teguh Rahayu Sri Teguh Rahayu, Sri Teguh Tantri Yanuar Rahmat Syah Tyas Putri Utami Uli, Syahdani Utami, Luciana Mery