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Martha Kaihena
Program Studi Sains Biomedis Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Pattimura Ambon, Indonesia
Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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The Potential of Ethanol Extract from Langsat Leaves (Lansium Domesticum Var. Pubescent) In Controlling Aedes Aegypti Mosquitoes: A Study on The Effectiveness of Natural Substances as Mosquito Repellents Abdul M Ukratalo; Muhammad Nurhidayat Ichsan; Martha Kaihena; Dodikrisno Ekaputra Manery; Victory Osvaldo Pangemanan; Debby Dijola Moniharapon
Journal of Biomedical Sciences and Health Vol. 1 No. 1 (2024)
Publisher : Universitas Karya Husada Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34310/jbsh.v1.i1.1

Abstract

Dengue keeps spreading through Aedes aegypti, and creeping resistance to synthetic larvicides such as temephos (Abate) has renewed interest in botanical alternatives. This study examined the larvicidal potential of ethanol extract from langsat leaves (Lansium domesticum var. pubescent), a plant already known to contain alkaloids, saponins, and terpenoids. Leaves were dried, macerated in ethanol, and concentrated by rotary evaporation before being diluted into four test concentrations. A completely randomized design was used with six groups — a negative control, a positive control (1% abate), and extract concentrations of 20%, 30%, 40%, and 50% — each with three replicates of 25 third-instar Aedes aegypti larvae, observed over 24 hours at six time points. Abate eliminated its entire larval population almost immediately, confirming assay validity. The extract itself produced a modest, dose-dependent effect: cumulative mortality rose from 38.67% at 20% and 30% concentrations to 43.99% at 40% and 53.77% at 50%. Two-way ANOVA followed by LSD testing showed that both concentration and observation time significantly affected mortality; the negative control differed significantly from the positive control and the 50% extract group, while the three lower concentrations did not differ from each other. Probit analysis placed LC50 at 45.24% (95% CI 42.67–48.44%) and LC90 at 67.57% (95% CI 60.25–84.83%), classifying the extract as moderately toxic on both measures. Langsat leaf extract thus shows measurable, if still limited, promise as a plant-based supplement to synthetic larvicides for dengue vector control.
Reproductive Health Optimization: Remarkable Benefits of Avocado Juice (Persea americana P. Mill) in Enhancing Production and Reducing Spermatozoal Abnormalities in Mice Exposed to Clove Cigarette Smoke Martha Kaihena; Abdul M Ukratalo; Victory O Pangemanan; Dodikrisno E Manery; Bill E Nanere; Yushar A Embisa
Journal of Biomedical Sciences and Health Vol. 1 No. 1 (2024)
Publisher : Universitas Karya Husada Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34310/jbsh.v1.i1.2

Abstract

Background: Cigarette smoke has the potential to disrupt hormonal balance, affect spermatogenesis processes, damage spermatozoa viability, and create the presence of toxic substances in spermatozoa. On the other hand, avocados contain protein and various vitamins, such as A, B, B1, B2, E, and C, as well as other substances, such as beta-carotene, linoleic acid, lecithin, calcium, iron, pantothenic acid, potassium, phosphorus, niacin, and natural plant oils. Vitamins C and E in avocados are believed to increase the number of Leydig cells and spermatozoa. Objective: This study aims to evaluate the potential of avocado juice to improve reproductive health in mice exposed to kretek cigarette smoke. Methods: Male mice (Mus musculus) aged 2 months, weighing ±20g each, were divided into 5 randomly assigned groups: K- (control without treatment), K+ (positive control exposed to cigarette smoke), P1 (mice exposed to cigarette smoke and given avocado juice at a dose of 0.5 ml/20 g BW), P2 (mice exposed to cigarette smoke and given avocado juice at a dose of 0.7 ml/20 g BW), and P3 (mice exposed to cigarette smoke and given avocado juice at a dose of 0.9 ml/20 g BW). Cigarette smoke exposure was conducted for 14 days. Results: The results showed that regular avocado juice consumption could increase sperm production and reduce spermatozoa abnormalities in mice exposed to kretek cigarette smoke. Conclusion: The clinical implications of these findings may contribute to a better understanding of avocado juice's potential as a supplement to improve reproductive health, especially in the context of kretek cigarette smoke exposure.
Co-Authors Abdul M Ukratalo Abdul M Ukratalo Bill E Nanere Debby Dijola Moniharapon Dodikrisno E Manery Dodikrisno Ekaputra Manery Muhammad Nurhidayat Ichsan Victory O Pangemanan Victory Osvaldo Pangemanan Yushar A Embisa