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Pemanfaatan Ekstrak Jagung (Zea Mays) di Kabupaten Grobogan Dalam Bentuk Sediaan Gel Sebagai Pelindung dari Sinar UVB: Array Gigih Kenanga Sari; Mauilita Saraswati
Pratama Medika : Jurnal Kesehatan Vol. 1 No. 1 (2022): Pratama Media: Jurnal Kesehatan
Publisher : Yayasan Citra Dharma Cindekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56480/pratamamedika.v1i1.705

The purpose of this study was to produce a gel preparation with corn kernel extract as raw material, product profile information and the safety effects of using corn kernel extract gel preparation. The method used in this study with corn extract formulated into HPMC base with concentrations of 5%, 10%, and 20%. Then performed physical testing, the effect of the gel in rabbits and on the skin of human hands. This research produces a gel preparation with corn kernel extract as the raw material. The gel produced by increasing the concentration of HPMC can increase the viscosity, stickiness, and decrease the spreadability, but the increase in the concentration of HPMC does not affect the pH. The results of the effect test on the skin showed that corn extract gel could function as a skin protector from the sun, but the difference in HPMC concentration did not give a difference in the effect of protecting the skin from the sun. This study resulted in a conclusion in the form of a gel preparation with corn kernel extract as raw material, the product profile increased viscosity, gel adhesion, and also decreased dispersion, but the increase in HPMC concentration did not affect the pH of the preparation and the gel was safe as a skin protector from the sun.

Formulation of Ethanol Extract Spray Gel Preparation of Sweet Starbumber Leaves (Averrhoa carambola L.) Eka Ammyta Putri Perdanti; Gigih Kenanga Sari; Maulita Saraswati
Pratama Medika : Jurnal Kesehatan Vol. 2 No. 1 (2023): Pratama Medika: Jurnal Kesehatan edisi Agustus - Oktober 2023
Publisher : Yayasan Citra Dharma Cindekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56480/pratamamedika.v2i1.935

The sweet star fruit leaf plant (Averrhoa carambola L.) is a plant that has many benefits, one part of the plant that is often used is the leaves which contain alkaloids, flavonoids, saponins and tannins that can be made indo spray gel preparations. Spray gel or commonly called spray gel is a gel that has an aqueous phase of 10-90% of the weight of the spray preparation. This research aims to formulate a spray gel preparation of ethanol extract of sweet starfruit leaves (Averrhoa carambola L.) by testing the physical stability of the spray gel preparation. The formulation of spray gel preparations of sweet starfruit leaf extract (Averrhoa carambola L.) with concentrations of 0.1%, 1% and 1.5% was researched using laboratory experimental methods. Physical stability tests of spray gel preparations include organoleptic tests, pH tests, homogeneity tests, viscosity tests, spray pattern tests, dry time tests, cycling tests and centrifugation tests.The results of testing the physical stability of spray gel preparations for each formula fall within the range of requirements for spray gel preparations. To test the physical stability of the spray gel preparation after the cycling test, the viscosity test and pH test for each formula showed a decrease in each formula, while the organoleptic test did not show a significant change in each formula after the cycling test. The centrifugation test results for each formula showed that it was stable, indicated by the absence of syneresis or phase separation. Based on research, it was found that at the highest concentration the spray gel preparation of ethanol extract of sweet star fruit leaves (Averrhoa crambola L.) had a good physical stability test.

Testing the Antibacterial Activity of A Serum Preparation of Pegagan Leaf Extract (Centella asiatica (L.) Urban) Against the Bacteria Propionibacterium acnes Bela Atika Putri; Gigih Kenanga Sari; Mingle A Pistanty
Pratama Medika : Jurnal Kesehatan Vol. 2 No. 1 (2023): Pratama Medika: Jurnal Kesehatan edisi Agustus - Oktober 2023
Publisher : Yayasan Citra Dharma Cindekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56480/pratamamedika.v2i1.936

Centella asiatica (L.) Urban) is one of the wild plants and has various benefits to treat various health problems. Centella asiatica can be used as an antioxidant, antigastritis, antitumor, wound healing, immunomodulator, antiproliferation, antibacterial and so on. Purpose: To know that serum extract of Centella asiatica leaves can provide antibacterial activity of Propionibacterium acnes. Method: The research used is experimental. Centella asiatica (L.) Urban leaves were extracted by maceration with 70% ethanol. Centella asiatica (L.) Urban leaf extract was made into serum with concentrations of 5%, 10% and 15%. Physical stability tests were carried out including organoleptic, homogeneity, pH, spreadability, adhesion and viscosity, then tested for the antibacterial activity of Propionibacterium acnes. Statistical analysis was performed using the ANOVA method. Results: Research shows that gotu kola leaf extract contains chemical compounds including triterpenoids, saponins, flavonoids, alkaloids and tannins. The serum preparation formulation is yellowish green in color, has a distinctive extract odor and is in semisolid form, homogeneous during storage, has a pH, stickiness, spreadability, and viscosity that meet the requirements for a good serum. The results of the drag power research were F1 of 7.68% mm, F2 of 11.52 mm and F3 of 16.68 mm. The statistical test results showed a significant effect on antibacterial activity, namely <0.05.

Serum Antibacterial Activity Test of Chinese Betel Extract (Peperomia Pellucida) Against Staphylococcus Aureus Bacteria Asri Satrianingrum; Gigih Kenanga Sari; Mingle A Pistanty
Pratama Medika : Jurnal Kesehatan Vol. 2 No. 1 (2023): Pratama Medika: Jurnal Kesehatan edisi Agustus - Oktober 2023
Publisher : Yayasan Citra Dharma Cindekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56480/pratamamedika.v2i1.938

Chinese betel is a weed plant that contains antibacterial compounds such as flavonoids, saponins, tannins, triterpenoids and alkaloids which are used as acne treatment therapy. The aim of the research is to obtain a serum with good inhibitory power from varying concentrations of 5%, 10% and 15%. , then a stability evaluation was carried out including organoleptic tests, homogeneity, pH, viscosity, spreadability and stickiness as well as testing for antibacterial activity against the growth of Staphyloccocus aureus. Data analysis was carried out using One-Way ANOVA. The results obtained from the stability test have good standards for organoleptics, homogeneity, pH, viscosity, spreadability and adhesion. Antibacterial testing showed that the diameter of the inhibition zone formed against Staphyloccocus aureus bacteria was 15.71 mm, 18.94 mm and 23.06 mm. Based on the results obtained, Chinese betel serum has good stability and all formulas can inhibit the growth of the acne-causing bacteria Staphyloccocus aureus as evidenced by the diameter of the inhibition zone formed which is in the very strong category

Antibacterial Activity Test of Cat's Whiskers Leaf Extract (Sauropus androgynus (L) Merr) Serum Preparation Against Propionibacterium acnes Bacteria Maulina Nur Riskiani; Gigih Kenanga Sari; Maulita Saraswati
Pratama Medika : Jurnal Kesehatan Vol. 2 No. 1 (2023): Pratama Medika: Jurnal Kesehatan edisi Agustus - Oktober 2023
Publisher : Yayasan Citra Dharma Cindekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56480/pratamamedika.v2i1.939

One of the inflammatory diseases that occurs in the pilosebaceous unit is acne. One of the bacteria that causes acne is Propionibacterium acnes. Katuk leaves contain flavonoids, saponins, tannins and alkaloids which can be used as an acne treatment. One of the pharmaceutical preparations that can be used to treat acne is serum. The aim of this research is to formulate katuk leaf extract into a serum preparation, determine the physical quality characteristics of the serum preparation and then determine the antibacterial activity against Propionibacterium acnes.The research method used is experimental. Katuk leaves were extracted by maceration method with 70% ethanol then serum preparations were made with various extract concentrations, namely FI 40%, FII 60% and FIII 80% on the basis of serum xanthan gum. The physical quality test of the serum preparation including organoleptic, pH, homogeneity, spreadability, adhesion and viscosity was carried out, then the antibacterial activity test of Propionibacterium acnes was carried out with positive control of clindamycin 10 µg/disk, negative control of 5% DMSO using disc diffusion method. The results of this study indicate that the formula has a semi-solid form, the color of FI is brownish green, FII is dark green and FIII is blackish green with a distinctive aroma of the extract, the formulation is homogeneous, has a pH, spreadability, adhesion and viscosity that meets the requirements of a good serum. The results of the antibacterial activity test showed that the negative control had no inhibition zone, the positive control showed a strong inhibition zone of 20.09 and the katuk leaf extract serum formulation had a moderate inhibition zone of FI 18.11, FII 19.21 and FIII 19.36 the greater the inhibition zone produced due to the higher concentration of the extract made. The results of statistical analysis of variations in extract concentrations showed significant differences in the inhibition zone based on One Way Anova statistical analysis (p<0.05).

Testing The Antibacterial Activitiy of A Facial Wash Preparation of Sweet Belimbing Leaf Extract (Averrhoa Carambola L.) Against The Bacteria Sthapyloccocus Epidermidi Dewi Rahayu Utami; Gigih Kenanga Sari; Mingle A Pistanty
Pratama Medika : Jurnal Kesehatan Vol. 2 No. 2 (2023): Pratama Medika: Jurnal Kesehatan edisi November 2023 - Januari 2024
Publisher : Yayasan Citra Dharma Cindekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56480/pratamamedika.v2i2.1035

Facial wash or what is usually called facial cleansing soap is the first step to preventing acne (Movita, 2013). This research aims to formulate a facial wash preparation of sweet starfruit leaf extract (Averrhoa carambola L.) with good physical quality evaluation and the potential to inhibit the growth of Staphylococcus epidermidis bacteria. Sweet starfruit leaf powder (Averrhoa carmbola L.) was extracted using the maceration method and with 70% ethanol solvent. The resulting thick extract is tested for chemical content, ethanol free and specific gravity of the extract. Next, an evaluation of the preparation was carried out and an antibacterial activity test was carried out on a facial wash preparation of sweet star fruit leaf extract (Averrhoa carambola L.) with an extract concentration of FI 30%, FII 40%, FIII 50%, using the diffusion method, paper discs, Mueller Hinton Agar media. The results of this research show that starfruit leaf extract (Averrhoa carmbola L.) can be made into a good facial wash preparation and contains alkaloids, flavonoids, saponins, tannins and triterpenoids, which can act as antibacterials. In facial wash preparations, sweet starfruit leaf extract (Averrhoa carmbola L.) produces good physical quality and can inhibit Staphylococcus epidermidi bacteria at FI of 13.503mm±0.580, FII of 38.026mm±4.34 and FIII of 42.51mm±3.178. This shows that the higher the concentration of sweet starfruit leaf extract, the higher the inhibitory power produced

Uji Aktivitas Antibakteri Serum Ekstrak Etanol 70% Daun Turi Putih (Sesbania grandiflora L) Terhadap Bakteri Staphylococcus Aureus Dita Purnama; Gigih Kenanga Sari; Maulita Saraswati
Pratama Medika : Jurnal Kesehatan Vol. 3 No. 1 (2024): Pratama Medika: Jurnal Kesehatan edisi Agustus - Oktober 2024
Publisher : Yayasan Citra Dharma Cindekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56480/pratamamedika.v3i1.1192

White turi is a plant that contains active substances that act as antibacterials, including saponins, flavonoids and tannins which can inhibit the growth of Staphylococcus aureus bacteria. Currently, the use of natural ingredients in cosmetic preparations has been developed. One of the cosmetic preparations that has developed recently is serum. This study aims to determine the antibacterial activity of serum 70% ethanol extract of white turi leaves (Sesbania grandiflora L) against Staphylococcus aureus bacteria. This research method is experimental research. White turi leaves were extracted using the maceration method with 70% ethanol solvent. The 70% ethanol extract of white turi leaves was made into serum with a concentration of 2%, 4%, 8% and the physical quality was evaluated including organoleptic tests, homogeneity, pH, spreadability, viscosity and the antibacterial activity of the serum was tested using the paper disk diffusion method. The results of the research on the formulation of the serum preparation are brownish yellow in color, have a distinctive odor of 70% ethanol extract of white turi leaves and are slightly thick, homogeneous, with a pH value = 5.65-5.86, spreadability = 5.3-6.33, viscosity = 341.66-466.46 and the inhibition zone for antibacterial activity of formula 1 is 9.48 mm (medium), formula 2 is 12.50 mm (strong) and formula 3 is 14.46 mm (strong). Based on the results obtained, it can be concluded that all serum formulas of 70% ethanol extract of white turi leaves can inhibit the growth of Staphylococcus aureus bacteria in the medium-strong category and the serum formula of 70% ethanol extract of white turi leaves (Sesbania grandiflora L) has the best activity on growth. Staphylococcus aureus bacteria is formula 3 with a concentration of 8% with an inhibition zone of 14.46 mm (strong).

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