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All Journal Biogenesis: Jurnal Ilmiah Biologi BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) Jurnal MedScientiae
Sabini, Jasmine Harumi
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Journal : Jurnal MedScientiae

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Caenorhabditis elegans sebagai Model Hewan Penelitian Biologi dan Biomedis Susilowati, Rina Priastini; Santoso, Adit Widodo; Sabini, Jasmine Harumi
Jurnal MedScientiae Vol. 3 No. 3 (2024): Desember
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i3.3467

Abstract

Caenorhabditis elegans is a microscopic nematode, with a transparent body, short life span, self-fertilization ability. C. elegans is easy to be cultured and has been used as an animal model for molecular research, medicine, pharmacology, and toxicology. In addition, C. elegans was the first animal to have its genome completely sequenced and has played a major role in understanding apoptosis and RNA interference. The use of C. elegans as a biological model in environmental toxicology assessments has allowed for the determination of several endpoints. Some of these utilize effects on the biological functions of the nematode and others use molecular markers. Furthermore, C. elegans has enabled the assessment of neurotoxic effects for pesticides and heavy metals, since this nematode has a very well-defined nervous system. Overall, almost every known toxin has been tested in this animal model. In the near future, the knowledge available about the life cycle of C. elegans will allow for more studies on reproduction, transgenerational toxicity for newly developed chemicals and materials, and detailing the signaling pathways involved in the mechanisms of toxicity. C. elegans is an important animal model for research into the identification and understanding of the machinery of nuclear transport. This has helped elucidate biochemical pathways involved in diseases such as obesity, diabetes, and Alzheimer's disease. C. elegans is an excellent animal model for studying aging because of its short lifespan, susceptibility to oxidative stress, and similarity to the human aging process.
The Role of Flavonoids as Immunomodulatory Agents: Therapeutic Potential and Mechanisms of Action Sabini, Jasmine Harumi; Susilowati, Rina Priastini; Sari, Monica Puspa
Jurnal MedScientiae Vol. 4 No. 1 (2025): April
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jmedscientiae.v4i1.3710

Abstract

Flavonoids are a group of polyphenolic compounds widely found in plants and have long been recognized for their biological activities, including antioxidant and anti-inflammatory effects. In recent years, increasing attention has been given to the potential of flavonoids as immunomodulatory agents. This review article aims to summarize and evaluate scientific evidence regarding the role of flavonoids in modulating both innate and adaptive immune responses. Several flavonoids, such as apigenin, genistein, quercetin, and naringenin, have been shown to suppress the production of proinflammatory cytokines, inhibit macrophage activation, and influence the differentiation of T cell subpopulations such as Th1, Th2, Th17, and Treg. In addition, some flavonoids have been found to inhibit inflammasome activation and may promote macrophage polarization toward either the M1 or M2 phenotype depending on the pathological context. Although preclinical data demonstrate promising results, challenges such as low bioavailability remain a major barrier to therapeutic application. Therefore, further research is needed to optimize the clinical potential of flavonoids as effective and safe immunomodulatory agents.
Prevalensi dan Faktor Risiko Penyakit Pedikulosis Kapitis di Sekolah Dasar Negeri Duri Kepa 11, Jakarta Barat Monica Puspa Sari; Far-Far, Inggrid; Sabini, Jasmine Harumi
Jurnal MedScientiae Vol. 4 No. 3 (2025): Desember
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jmedscientiae.v4i3.3798

Abstract

Pediculosis capitis is a head lice disease because it causes discomfort to sufferers in the world. The disease can affect all ages and especially elementary school children. The purpose of this study was to determine the prevalence of pediculosis capitis and risk factors for infestation in children at SDN Duri Kepa 11, West Jakarta. The research method was observational analytic with a cross sectional approach conducted in November 2023. The sample size of the study was 323 samples with a total sampling technique. Head lice examination was carried out visually and using a lice comb. Samples responses were collected through questionnaires. Bivariate data analysis was carried out using SPSS 25. The prevalence of pediculosis capitis in children at SDN Duri Kepa 11 was 23,8%, higher in female students, certain classes and students with housewives. Factors related to pediculosis capitis infestation at SDN Duri Kepa 11 were gender (p value = 0,000), hair shape (p value = 0,004), frequency of hair washing (p value = 0,007) and use of shared combs and towels (p value = 0,000). The prevalence of pediculosis capitis in children aged 7-13 years at SDN Duri Kepa 11, west Jakarta is quite high so that prevention and treatment are needed so that the prevalence can be further reduced.
Co-Authors Far-Far, Inggrid Monica Puspa Sari Monica Puspa Sari Santoso, Adit Widodo Susilowati, Rina Priastini