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All Journal HAYATI Journal of Biosciences Bioscience Vektora : Jurnal Vektor dan Reservoir Penyakit Biogenesis: Jurnal Ilmiah Biologi Indonesian Journal of Tropical and Infectious Disease BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) Jurnal Biodjati YARSI Medical Journal Jurnal Pembelajaran dan Biologi Nukleus Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek) SERVIRISMA: Jurnal Pengabdian kepada Masyarakat Jurnal MedScientiae Jurnal MedScientiae Jurnal Kedokteran Meditek
Susilowati, Rina Priastini
Universitas Kristen Krida Wacana
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary Other

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Efektivitas Ekstrak Daun Maja (Aegle marmelos (L) Corr) sebagai Larvasida Aedes aegypti Priastini Susilowati, Rina; Puspa Sari, Monica
Jurnal Kedokteran YARSI Vol 27, No 1 (2019): JANUARI - APRIL 2019
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (156.943 KB) | DOI: 10.33476/jky.v27i1.797

Abstract

Tanaman maja (Aegle marmelos), dikenal dengan ”Bael atau Maja” dapat ditemukan disekitar kita, dapat dimanfaatkan sebagai larvasida alami karena ramah lingkungan dan relatif lebih  aman bila dibandingkan dengan pestisida kimiawi yang mulai menimbulkan resistensi bagi hewan targetnya. Kandungan beberapa senyawa kimia seperti alkaloid, terpenoid dan tannin  kemungkinan bersifat larvasida maka diperlukan untuk mengetahui apakah ekstrak daun maja menggunakan pelarut etil asetat dan etanol efektif dapat membunuh larva Aedes aegypti  dengan berbagai konsentrasi yaitu 1%; 2%; 4%, 8%; dan 16%, dengan satu kelompok kontrol  positif berupa temephos 1% dan kontrol negatif (tanpa paparan). Rancangan yang digunakan  adalah rancangan acak lengkap (RAL) dengan ulangan sebanyak empat kali. Penelitian ini dilakukan di laboratorium penelitian fakultas kedokteran Universitas Kristen Krida Wacana (UKRIDA) dengan populasi larva sebanyak 25 larva  per ulangan. Kematian larva Aedes aegypti diamati 24 jam setelah terpapar. Data yang diperoleh akan dianalisis menggunakan uji one way Anova dan dilanjutkan dengan uji beda  nyata terkecil (uji BNT) untuk mengetahui apakah ada perbedaan yang bermakna antara temephos 1% dengan ekstrak daun maja dosis bertingkat yang menggunakan pelarut etil  asetat maupun etanol dalam berbagai konsentrasi. Hasil penelitian menunjukkan nilai LC50  dan LC90 dari pelarut etil asetat sebesar 2,03% dan 3,04%. Sedangkan nilai LC50 dan LC90  menggunakan pelarut etanol sebesar 4,12% dan 10,82%. Dapat disimpulkan bahwa ekstrak  daun maja menggunakan pelarut etil asetat mempunyai aktivitas larvasida yang lebih tinggi  dibandingkan menggunakan pelarut etanol.
Efficacy of knockdown insecticide based on Permot (Passiflora foetida L.) leaf extract against mortality of German cockroach (Blattella germanica L.) Rina Priastini Susilowati; Flora Rumiati
Biogenesis: Jurnal Ilmiah Biologi Vol 9 No 2 (2021)
Publisher : Department of Biology, Faculty of Sci and Tech, Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/bio.v9i2.24100

Abstract

Chemical insecticides have a detrimental effect on not only the target species, but also on non-target species and the environment. Transfluthrin is a pyrethroid class II insecticide that is considered to be safe for humans. However, repeated use over an extended period of time can result in cockroach resistance. For this reason, this study sought out alternative materials, specifically Permot leaf (Passiflora foetida L.). This study aims to determine the neurotoxic efficacy of insecticides derived from Permot leaf extract on German cockroach knockdown time and death. A total of 120 German cockroaches and was replicated three times. After 1 h of exposure to insecticides containing transfluthrin 3000 ppm and Permot leaf extract up to a dose of 4000 ppm, knockdown time and cockroach death were observed. The probit test was used to determine the cockroach knockdown time. The study's findings indicated that when cockroaches were exposed to insecticides derived from Permot leaves at a dose of 4000 ppm, the knockdown efficacy was KT50 for 8 min and KT90 for 30 min. The blocking test on German cockroach spiracles established that exposure via cockroach spiracles was more effective than exposure via other cockroach organs in killing.
Histopathological Changes of Testes and Testosterone Level of Mice that are Exposed to Permot Leaf Mosquito Mat (Passiflora foetida) Rina Priastini Susilowati
Bioscience Vol 3, No 1 (2019): Biology
Publisher : UNIVERSITAS NEGERI PADANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (663.005 KB) | DOI: 10.24036/0201931103791-0-00

Abstract

In this study, mice testicular degeneration was influenced by exposure to the mosquito mat made from transfluthrin 3000 ppm and permot leaf mosquito mat which were evaluated based on observations on testicular histopathological changes and testosterone level. Fifteen Balb C male mice aged 2-3 months with a body weight of 25-30 g were divided into five groups, namely A, B, C, D, and E, with each group consisting of 3 replications. Group A was the negative control group (without exposure), group B was the exposure group for the mosquito mat made from transfluthrin 3000 ppm, group C, D, and E were the exposure groups of mosquito mat with permot leaves doses of 1000 ppm, 2000 ppm and 3000 ppm. Each exposure group was given treatment 8 hours per day from 18.00 - 04.00 for 3 months. The results showed a significant decrease in testicular weight between the control group and the treatment group. There were also significant differences in the testosterone level observed in the treatment group, as well as observations on the spermatogenic index (IS). For histopathological observation of testicular mice, there was a reduction in epithelial cell spermatogenic and diameter of seminiferous tubule. The results of the Kruskall Wallis test showed a significant difference between the control group and the treatment group of the mosquito mat made from transflutrin 3000 ppm. The conclusion is that exposure to mosquito mat made of permot peaves up to a 3000 ppm dose is safe to use and can kill the Aedes aegypti mosquito effectively.
EFEKTIVITAS INFUSA UMBI BAWANG MERAH (Allium cepa) DAN KULIT JERUK LIMAU (Citrus amblycarpa) TERHADAP LARVA Aedes aegypti Monica Puspa Sari; Rina Priastini Susilowati
Vektora : Jurnal Vektor dan Reservoir Penyakit Vol 12 No 2 (2020): Vektora : Jurnal Vektor dan Reservoir Penyakit
Publisher : Balai Besar Penelitian dan Pengembangan Vektor dan Reservoir Penyakit (B2P2VRP) Salatiga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/vk.v12i2.2410

Abstract

The use of active chemical compounds contained in plants is needed to control the Ae. aegypti mosquito vector which is resistant to many chemical insecticides. These plants are shallot bulbs and lime peels. The use of natural larvacides is expected to have no side effects on humans, the environment, or resistance. This study aims to determine the effectiveness of shallot tuber infusion, and lime peel on Ae. aegypti larvae in various concentrations. This study used a completely randomized design with positive control treatments in the form of temephos 1%, negative control (without exposure), infusion of shallots, and lime peels with water solvent and concentrations of 1%,2%4%,8%, and 16% with 4 repetitions. In this study Ae. aegypti larvae instar III were used as many as 25 larvae per replications, and observation of Ae. aegypti larvae are done within 24 hours. The data obtained were analyzed using the one-way ANOVA test, if the results were very significant (p < 0.01) then it would be followed by the smallest real difference test. The LC50 and LC90 probits tests were used to determine the effective dose of the two plants. The results showed that the LC50 value for the infusion of shallots and lime peels was 3,04%; 3,42% and d LC90 of 6,49%; 6,98%. The study concludes that the infusion of shallots and lime peel can be used as larvacide Ae. aegypti which is natural because the mortality rate is close to 90%. Abstrak Pemanfaatan senyawa kimia aktif yang terkandung dalam tanaman sangat diperlukan untuk mengendalikan vektor nyamuk Ae. aegypti yang telah resisten terhadap insektisida kimia. Tanaman yang akan dimanfaatkan adalah umbi bawang merah dan kulit jeruk limau. Penggunaan larvasida alami diharapkan tidak mempunyai efek samping terhadap manusia, lingkungan maupun kejadian resistensi. Penelitian ini bertujuan untuk mengetahui efektivitas infusa umbi bawang merah dan kulit jeruk limau terhadap larva Ae. aegypti dalam berbagai konsentrasi. Penelitian ini menggunakan rancangan acak lengkap dengan perlakuan kontrol positif berupa temephos 1%, kontrol negatif (tanpa paparan), infusa umbi bawang merah dan kulit jeruk limau dengan pelarut air dan konsentrasi bertingkat 1%, 2%, 4%, 8% dan 16% dengan ulangan sebanyak 4 kali. Dalam penelitian ini digunakan larva Ae. aegypti instar III sebanyak 25 ekor larva per ulangan, dan pengamatan larva Ae. aegypti dilakukan dalam waktu 24 jam. Data yang diperoleh dianalisis menggunakan uji One-Way Anova, apabila hasilnya berbeda sangat bermakna (p< 0.01) maka akan dilanjutkan dengan uji beda nyata terkecil. Uji probit LC50 dan LC90 digunakan untuk mengetahui dosis efektif dari kedua tanaman tersebut. Hasil penelitian diperoleh nilai LC50 infusa umbi bawang merah dan kulit jeruk limau sebesar 3,04%; 3,42% dan LC90 sebesar 6,49%; 6,98%. Kesimpulan penelitian ini adalah infusa umbi bawang merah dan kulit jeruk limau dapat digunakan sebagai larvasida Ae. aegypti yang bersifat alami karena nilai mortalitasnya yang mendekati 90%.
Uji Toksisitas Obat Nyamuk Bakar Herbal Berbahan Ekstrak Daun Permot (Passiflora Foetida) : Kajian Histopatologis Hati dan Ginjal Mencit Rina Priastini Susilowati
Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek) 2016: Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1081.13 KB)

Abstract

Aedes aegypti adalah nyamuk yang berperan sebagai vector penyakit demam berdarah dengue (DBD). Salah satu upaya untuk mengendalikan populasi Aedes aegypti menurunkan angka kematian karena penyakit DBD melalui pemanfaatan bioinsektisida. Ekstrak biji krisan yaitu piretrin telah banyak digunakan sebagai bahan dasar obat nyamuk bakar, sedangkan ekstrak daun permot (Passiflora foetida) belum banyak diteliti dan dimanfaatkan sebagai salah satu bahan aktif obat nyamuk. Uji toksisitas obat nyamuk bakar berbahan ekstrak daun permot (Passiflora foetida) dilakukan pada hewan mencit jantan (Mus musculus). Penelitian ini dilakukan untuk mengetahui efek organ hati dan ginjal mencit jantan yang diberi paparan obat nyamuk bakar berbahan ekstrakdaun permot. Satu kelompok kontrol (tanpa paparan obat nyamuk bakar) dan lima kelompok perlakuan paparan obat nyamuk bakar berbahan ekstrak daun permot dengan dosis 500 ppm, 1000 ppm, 2000 ppm, 3000 ppm dan 4000 ppm. Sediaan hati dan ginjal dibaca dan dianalisis dengan menggunakan mikroskop cahaya pembesaran 400x untuk melihat perubahan gambaran histopatologisnya. Data dianalisis dengan uji Anova dilanjutkan dengan uji Post Hoc bila berdistribusi normal atau dengan uji Kruskal Wallis yang dilanjutkan dengan uji Mann Whitney bila tidak berdistribusi normal. Tidak ada mencit yang mati maupun menunjukkan gejala toksikseperti hiperagresifitas maupun kepasifan setelah paparan obat nyamuk bakar berbahan ekstrak daun permot. Secara histopatologis pemberian paparan obat nyamuk bakar berbahan ekstrak daun permot dosis 500 ppm hingga 3000 ppm tidak menunjukkan kerusakan jaringan di hati maupun ginjal seperti halnya kelompok kontrol, sedangkan dosis 4000 ppm menyebabkan hati dan ginjalmencit jantan mengalami nekrosis sel parenkim.
Effects of Passiflora foetida on the Number of Purkinje Cells in the Cerebellum of Albino Rats Rina Priastini Susilowati; Budiman Hartono
Jurnal Biodjati Vol 7, No 2 (2022): November
Publisher : UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/biodjati.v7i2.14298

Abstract

 Permot (Passiflora foetida) is one type of plant that has been used as a mosquito coil. Besides being effective at killing Aedes aegypti mosquitoes, mosquito coils made from permot leaf extract are also effective at killing German cockroaches and house flies. Until now there have been no reports stating the side effects of using permot leaf extract in humans. This study was designed to demonstrate the harmful side effects of inhalation of smoked mosquito coils made from permot leaf extract on the cerebellar cortex of adult male rats. Thirty-five adult male rats were used in this study. Rats were divided into 7 groups, namely group 1 as a negative control (without exposure), group 2 as a positive control (transfluthrin exposure 3000 ppm), groups 3 to 7 were treatment groups of permot leaf extract with graded doses (500 ppm, 1000 ppm, 2000 ppm, 3000 ppm, and 4000 ppm), and was treated for 12 weeks. All rats were sacrificed in a timely manner and cerebellar specimens were taken, prepared and observed using a light microscope. Previously, rats were weighed periodically to determine the effect of toxicity. The results showed that exposure to mosquito coil smoke made from 3000 ppm Transflutrin and 4000 ppm permot leaf extract caused weight loss in rats. Likewise on the weight of the rat cerebellum. The effect of decreasing the number of Purkinje cells also occurred in the group exposed to mosquito coils made from Transflutrin 3000 ppm and permot leaf extract 4000 ppm. Therefore, the safe and effective dose of mosquito coils made from permot leaves is less than 4000 ppm, because exposure to doses of more than 4000 ppm can cause degenerative changes in the cerebellar cortex.
Pengaruh Aktivitas Fisik Dan Kualitas Tidur Terhadap Prestasi Akademik Peserta Didik Fakultas Kedokteran UKRIDA Angkatan 2019 maria caecaelia botoor; Rina Priastini Susilowati; Jodie Josephine
Jurnal MedScientiae Volume 1 No 01 : Mei - Agustus 2022
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Ukrida

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (334.67 KB) | DOI: 10.36452/jmedscientiae.vi.2439

Abstract

Background: Sleep is an active behavior that is carried out by humans continuously where the quality of sleep is a benchmark for a person to be able to enjoy sleep and maintain the stability of his body. Physical activity that is carried out consistently and regularly can have a great influence on a person's physical condition. Academic achievement is the result of a student's learning which is the most important part of education. This study used a quantitative descriptive study method, cross-sectional by taking data through a questionnaire. The study showed that the Class of 2019 students had good sleep quality and did sufficient physical activity. Where physical activity has a significant effect on the level of academic achievement of the students of the Faculty of Medicine Ukrida Batch 2019. Based on a partial test with a significance value of 0.406 (> 0.05) which shows that there is an influence between physical activity on academic achievement. . Based the partial test with a significance value of 0.220 (> 0.05) which indicates the influence of sleep quality on academic achievement. The F test is a joint test of the regression coefficients by comparing the p-value with a certain level of significance.
Perubahan Histopatologis Sel Epitel Midgut Larva Nyamuk Aedes aegypti Akibat Paparan Insektisida Nabati Dwi Anggraini; Monica Puspa; Rina Priastini Susilowati
Jurnal MedScientiae Volume 1 No 01 : Mei - Agustus 2022
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Ukrida

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (305.069 KB) | DOI: 10.36452/jmedscientiae.vi.2440

Abstract

Aedes aegypti mosquitoes are the main vector of Dengue Hemorrhagic Fever (DHF). Various prevention efforts were carried out to reduce their population. One of them is the use of synthetic or bioinsecticides. Bioinsecticides are safer for humans, animals and the environment so they had been used widely as an alternative nowadays. Larvicide is one of the insecticides product that attacks mosquito breeding sites in the water. Larvicide has various mechanisms that can attack some target organs including larvae’s midgut. Based on several trial results, plant insecticides have been cause epithelial cells in larvae’s midgut to lyses, change shape, vacuolize and detach from the basal membrane. Peritrophic membrane, microvilli and brush border are partially or completely damage. Histopathological changes in the midgut epithelial cells of Ae. aegypti larvae were caused by metabolite compounds, either singly or in combination that contained in plant extracts
Literature Review: Pengaruh Kebiasaan Jajan dan Higienitas Jajanan terhadap Kejadian Diare pada Anak SD Rina Priastini Susilowati; Budiman Hartono; Bryan Reyes Stephen
Jurnal MedScientiae Volume 1 No 01 : Mei - Agustus 2022
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Ukrida

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (695.517 KB) | DOI: 10.36452/jmedscientiae.vi.2447

Abstract

Consuming street food is a habit common among elementary school students. Snacking habits can be influenced by parents and friends, and various other factors. The hygiene of the snacks in school environment is also a consideration. This study aims to determine the effect of snacking habits and snacks hygiene on incidence of diarrhea among elementary school students. The study was conducted by comparing available data from six journals. The results showed conflicting data on the effect of snacking habits on incidence of diarrhea with two sources showing significant (p < 0.05) and insignificant (p > 0.05) impact. Hand washing habits (p < 0.05), carrying meals (p < 0.05), and knowledge (p < 0.05) had a significant influence on snacking habits and incidence of diarrhea. For snack hygiene, food quality (p < 0.05); storage (p < 0.05); and processing (p < 0.05); sanitation facilities (p < 0.05); and food handlers’ hygiene (p < 0.05) had a significant effect on E.coli contamination. Apart from hygiene, some snacks were found to contain harmful food additives. In conclusion, it is necessary to conduct an educational program for healthy snacks as well as monitor and maintain canteen hygiene on a regular basis.
Larvicidal Activity of Ethyl Acetate Leaf Extract of Aegle marmelos (L.) Correa Against Aedes aegypti Monica Puspa Sari; Rina Priastini Susilowati; Kris Herawan Timotius
HAYATI Journal of Biosciences Vol. 30 No. 4 (2023): July 2023
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.30.4.643-652

Abstract

Aegle marmelos leaf contains secondary metabolites that have bioinsecticidal effects. This study aimed to analyze phytoconstituents of the ethyl acetate extract of Aegle marmelos leaves, its larvicidal activity, and its effects on histopathological changes of the midgut of Aedes aegypti larvae. The ethyl acetate extract was obtained from the concentrated maceration of the leaf powder and analyzed with GCMS. The instar III or IV larvae were used and divided into six groups where each group was exposed to an extract with a concentration of 1%; 4%; 8% and 16%, and one other control group without exposure to such extract. The histopathology of larval midgut was prepared, stained with Hematoxyllin-Eosin, and observed using light microscopy. GC-MS analysis revealed that the extracts contain 8 compounds, Oleic acid, 9-Hexadecenoic acid, Cis-1,3-Eicosenoic acid, Dasycarpidan-1-methanol, acetate (ester), Digitoxin, Z-(13,14-epoxy)tetradeg-11-en-ol acetate; 2,3-dimethyl-5-trifluoromethyl-1-phen-1,4-diol, ethyl iso-allocholate. Probit test revealed that the LC50 value of ethyl acetate extract of Aegle marmelos leaves was 3.917% and histopathological results are damage to brush borders, nucleus and nucleolus, epithelial cells, and hypertrophy of the gastric caeca. The leaf ethyl acetate extract from Aegle marmerlos can be considered as a probable natural insecticide to kill Aedes aegypti. Aegle marmelos can be applied as natural insecticide to eradicate the population of Ae. aegypti.
Co-Authors Alexander Anna Maria Dewajanti Beatrix Clarissa Gunarta Bryan Reyes Stephen Budiman Hartono Budiman Hartono Budiman Hartono Dwi Anggraini Ernawaty Tamba Flora Rumiati Flora Rumiati Flora Rumiati Henricho Himawan Hidajat, Joshua Jean Michael Indah Pratiwi Inggrid Osya Farfar Inneke Kusumawati Susanto Jodie Josephine Kris Herawan Timotius Liauw Djai Yen Marcel Antoni maria caecaelia botoor Michelle Amelia Tanian Monica Puspa Monica Puspa Sari Monica Puspa Sari Monica Puspa Sari Monica Puspa Sari Monica Puspa Sari Monica Puspa Sari Monica Puspa Sari Nainggolan, Edward Anderson Nanik Siti Aminah Pratanu, Lydia Puspa Sari, Monica Putri, Dyah Ayu Adella Sabini, Jasmine Harumi Sancia Nathania Legenie Banuang Santoso, Adit Widodo Win Darmanto Yanto Hindrawan