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All Journal Jurnal Bioteknologi & Biosains Indonesia (JBBI) Journal of Medicine and Health
Siti Mahyuni
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Health Professions Medicine & Pharmacology Public Health

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MICROBIAL BIOCONVERSION TO PRODUCE NUTRACEUTICAL AND PHARMACEUTICAL BIOACTIVE COMPOUNDS Siti Mahyuni
Jurnal Bioteknologi dan Biosains Indonesia Vol. 9 No. 1 (2022)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

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Abstract

he bioconversions of bioactive health supporting compounds using certain microorganisms have long been known, however it has not been widely applied in industrial scale to produce nutraceutical and products of high economic value. This review article will discuss the group of steroids, carotenoids and statins which were produced by microbial bioconversion using the various substrates and conditions. The information presented in this article were collected from scientific books and articles in national and international journals which can be validated and traced back to their sources through many sites such as google.com, google scholar, NCBI and Science Direct. From the information compiled in this article, it can be concluded that the bioconversion of bioactive compounds by microorganisms has shown positive results and potential to be further optimized and applied in an industrial scale to produce natural bioactive compounds as basic ingredients for nutraceutical and pharmaceutical products with high economic value.
Uji Aktivitas Antibakteri Ekstrak Metanol, Ekstrak Fraksi N-Heksan dan Ekstrak N-Heksan Daun Filicium decipiens terhadap Bakteri Staphylococcus aureus dan Bakteri Bacillus subtilis Siti Mahyuni; Trirakhma Sofihidayati
Journal of Medicine and Health Vol 2 No 5 (2020)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v2i5.2004

Abstract

The previous study shows ethanol extract of Filicium decipiens leaf possesses a strong antibacterial activity against Staphylococcus aureus, but there have been no studies of the antibacterial activity with different solvents. The purpose of this study was to determine the antibacterial activities of methanol, n-hexane fraction of methanol and n-hexane extract of F. decipiens leaves against S. aureus and Bacillus subtilis bacteria. Extraction was carried out by soxletation method using methanol and n-hexane solvent. The antibacterial activity test was done by measuring the minimum inhibitory concentration (MIC) and Zone of Inhibition. The results showed that methanol extract did not have activity either against S. aureus bacteria or against B. subtilis. N-hexane extract which was fractionated from methanol extract had no activity against B. subtilis but showed moderate activity against S. aureus with 9 mm inhibition diameter at an extract concentration of 40%. N-hexane extract has very strong antibacterial activity against S. aureus with inhibition diameter reaching 21 mm at extract concentration of 30% and showing strong activity against B. subtilis bacteria with inhibition diameter of 10 mm at extract concentration of 30%. It can be concluded that n-hexane extract from F. decipiens has a potent as natural antibiotic material. Keywords: Filicium decipiens; Staphylococcus aureus; Bacillus subtilis; n-hexane extract; methanol extract
Co-Authors Anindita Aulya Pertiwi Fitria Dewi Sulistiyono Ike Yulia Wiendarlina Ivan Mahardika Putra Toyotatu Julmudia Nurul Annisa Maidatun Hasanah Nurul Safira Prasetyorini Djarot Trirakhma Sofihidayati Yulianita Zahriani