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All Journal Jurnal Sehat Mandiri MEDALION JOURNAL: Medical Research, Nursing, Health and Midwife Participation
Muhammad Arsyad
Universitas Borneo Lestari
Dentistry Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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RELATIONSHIP BETWEEN WIDAL TITER WITH C-REACTIVE PROTEIN (CRP) LEVELS AND SEGMENTED NEUTROPHIL PERCENTAGE IN CHILDREN WITH TYPHOID FEVER AT GRAHA MEDIKA MARTAPURA CLINIC, BANJAR DISTRICT Eka Wahyuni; Puspawati; Muhammad Arsyad; Syihab Fayumi
MEDALION Journal: Medical Research, Nursing, Health and Midwife Participation Vol. 7 No. 2 (2026): June
Publisher : PT. Radja Intercontinental Publishing

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Abstract

Typhoid fever is an infectious disease that remains a public health problem in Indonesia, particularly among children. Infection with Salmonella typhi can trigger an inflammatory response characterized by elevated C-reactive protein (CRP) levels and changes in the percentage of segmented neutrophils. The Widal test is still widely used to aid in the diagnosis of typhoid fever because it is simple, rapid, and cost-effective. This study aimed to determine the relationship between Widal titers and CRP levels and the percentage of segmented neutrophils in pediatric typhoid fever patients at the Graha Medika Martapura Clinic, Banjar Regency. This study employed an observational analytical method with a cross-sectional design. The data used were secondary data from the medical records of pediatric typhoid fever patients from January 2025 to March 2026. The study sample consisted of 206 patients selected using total sampling. Data analysis was performed using the Spearman rank correlation test. The results showed that the majority of patients had a Widal titer of 1/640 (65.5%), elevated CRP levels (59.7%), and a normal percentage of segmented neutrophils (84.5%). The correlation test results showed no significant association between the Widal titer and CRP levels (r=0.073; p=0.296) or the percentage of segmented neutrophils (r=0.064; p=0.361). It was concluded that the Widal titer is not associated with CRP levels or the percentage of segmented neutrophils in pediatric patients with typhoid fever.
Perbandingan Jumlah Leukosit Menggunakan Ekstrak Buah Limau Kuit sebagai Reagensia Alternatif Muhammad Arsyad; Nurul Amalia; Nurbidayah Nurbidayah
Jurnal Sehat Mandiri Vol 20 No 1 (2025): Jurnal Sehat Mandiri, Volume 20 Nomor 1 Juni 2025
Publisher : Poltekkes Kemenkes Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33761/jsm.v20i1.1856

Abstract

Limau kuit (Citrus hystrix DC) is a fruit that has a distinctive sour taste. The sourness in limau kuit extract can be used to replace glacial acetic acid, which is one of the compounds found in reagents used to aid in the diagnosis of certain diseases. One of the reagents that contains acetic acid is Turk’s solution, which functions to stain leukocyte cells and lyse other cells except leukocytes, thus enabling leukocyte count analysis. The objective of this study was to count leukocytes using a modified Turk’s solution made from limau kuit extract and compare the results with those obtained using commercial Turk’s solution. The study design was a randomized post-test only controlled group design, using instruments such as a microscope, micropipette, test tubes, and an improved Neubauer chamber. The research was conducted in the pathology laboratory of Universitas Borneo Lestari in October 2024. Leukocyte count examinations were performed in 16 repetitions, followed by statistical data analysis using the Independent Sample T-Test. The results showed that the leukocyte counts obtained using the modified Turk’s solution from limau kuit extract did not show a significant difference. The difference in mean leukocyte count was 40.63 cells/mm³, with a median difference of 100 cells/mm³, a maximum difference of 150 cells/mm³, and a minimum difference of 200 cells/mm³. Microscopically, erythrocytes were completely lysed and leukocytes were clearly visible; however, bacterial contamination was still observed in the field of view. In conclusion, the modification of Turk’s reagent using limau kuit extract showed no significant difference between the control group (commercial Turk’s reagent) and the treatment group.
Co-Authors Eka Wahyuni Nurbidayah Nurul Amalia Puspawati Syihab Fayumi