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All Journal Global Medical and Health Communication Jurnal Teknokes
Elmanar, Ryan
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Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Nursing Public Health

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Correlation between Length-to-width Ratio of Gallbladder and Gamma-glutamyl Transferase Value in Biliary Atresia Elmanar, Ryan; Violetta, Lenny; Setiawati, Rosy
Global Medical & Health Communication (GMHC) Vol 12, No 3 (2024)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v12i3.14170

Abstract

Biliary atresia represents one of the most prevalent etiologies for neonatal cholestasis. Unmanaged biliary atresia can be fatal. Ultrasonography is the primary diagnostic test because it's accurate, cost-effective, and available. Various ultrasound findings can assist in diagnosing biliary atresia; the length-to-width ratio of the gallbladder is a particularly advantageous method, offering a short examination time, objectivity, and ease of use, with an accuracy rate of 78.9%. In cases with unconventional ultrasound findings, gamma-glutamyl transferase is believed to be able to complete the diagnostic process with an accuracy rate of up to 80%. The optimal cut-off value differs between studies, making it challenging to use as a benchmark for biliary atresia detection. In this study, researchers aim to further investigate the relationship between length-to-width ratio and gamma-glutamyl transferase in cases of biliary atresia, compared to the liver biopsy results in these patients and the optimal cut-off. This study employed an observational analytic approach with a retrospective design. The sample population consisted of all patients with neonatal cholestasis who underwent laboratory and ultrasonographic examinations at Dr. Soetomo Academic General Hospital Surabaya between 2019 and 2023. The study population comprised 82 patients. A significant relationship (p-value<0.001) was observed between the length-to-width ratio of the gallbladder and biliary atresia, as well as between gamma-glutamyl transferase and biliary atresia (area under the curve: 0.7–0.8). However, the analysis between the length-to-width ratio of the gallbladder and the value of gamma-glutamyl transferase showed p-value=0.066, which means no significant relationship was observed between the length-to-width ratio and gamma-glutamyl transferase.
Correlation between Length-to-width Ratio of Gallbladder and Gamma-glutamyl Transferase Value in Biliary Atresia Elmanar, Ryan; Violetta, Lenny; Setiawati, Rosy
Global Medical & Health Communication (GMHC) Vol 12, No 3 (2024)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Biliary atresia represents one of the most prevalent etiologies for neonatal cholestasis. Unmanaged biliary atresia can be fatal. Ultrasonography is the primary diagnostic test because it's accurate, cost-effective, and available. Various ultrasound findings can assist in diagnosing biliary atresia; the length-to-width ratio of the gallbladder is a particularly advantageous method, offering a short examination time, objectivity, and ease of use, with an accuracy rate of 78.9%. In cases with unconventional ultrasound findings, gamma-glutamyl transferase is believed to be able to complete the diagnostic process with an accuracy rate of up to 80%. The optimal cut-off value differs between studies, making it challenging to use as a benchmark for biliary atresia detection. In this study, researchers aim to further investigate the relationship between length-to-width ratio and gamma-glutamyl transferase in cases of biliary atresia, compared to the liver biopsy results in these patients and the optimal cut-off. This study employed an observational analytic approach with a retrospective design. The sample population consisted of all patients with neonatal cholestasis who underwent laboratory and ultrasonographic examinations at Dr. Soetomo Academic General Hospital Surabaya between 2019 and 2023. The study population comprised 82 patients. A significant relationship (p-value<0.001) was observed between the length-to-width ratio of the gallbladder and biliary atresia, as well as between gamma-glutamyl transferase and biliary atresia (area under the curve: 0.7–0.8). However, the analysis between the length-to-width ratio of the gallbladder and the value of gamma-glutamyl transferase showed p-value=0.066, which means no significant relationship was observed between the length-to-width ratio and gamma-glutamyl transferase. DOI: https://doi.org/10.29313/gmhc.v12i3.14170
Early Detection of Biliary Atresia through Quantitative Ultrasound Imaging: A Retrospective Analysis of Key Diagnostic Features Violetta, Lenny; Nurhayati, Dian; Elmanar, Ryan
Jurnal Teknokes Vol. 18 No. 3 (2025): September
Publisher : Jurusan Teknik Elektromedik, Politeknik Kesehatan Kemenkes Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Biliary atresia (BA) is a progressive fibroinflammatory obstruction of the intra- and extrahepatic bile ducts, accounting for approximately 25–30% of neonatal cholestasis cases worldwide. Delayed diagnosis significantly increases the risk of liver failure and the need for transplantation. This study aimed to evaluate the diagnostic value of specific ultrasonographic parameters triangular cord sign, hepatic artery to portal vein (HAD/PV) ratio, and hepatic subcapsular flow (HSF) in the early detection of BA. A retrospective observational analytic study was conducted at Dr. Soetomo General Academic Hospital, involving 82 neonates with cholestasis between January 2019 and December 2023. Ultrasound images acquired using the GE LOGIQ Series E9 XDClear 2.0 were reviewed by blinded pediatric radiology consultants via the HOROS DICOM viewer. Statistical analysis revealed that both the triangular cord sign (p = 0.024; OR = 3.158) and hepatic subcapsular flow (p = 0.003; OR = 5.635) showed significant association with BA, while the HAD/PV ratio did not reach statistical significance (p = 0.087). Triangular cord sign and hepatic subcapsular flow are reliable sonographic markers that support early diagnosis of biliary atresia, whereas the HAD/PV ratio showed limited diagnostic relevance in this cohort. These findings reinforce the utility of non-invasive ultrasound imaging in differentiating BA from other causes of neonatal cholestasis. Incorporating these parameters into routine neonatal screening protocols may facilitate earlier surgical intervention and improve long-term outcomes
Co-Authors Dian Nurhayati, Dian Setiawati, Rosy Violetta, Lenny