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All Journal INJURITY: Journal of Interdisciplinary Studies Jurnal Info Kesehatan
Restalia, Fianda
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Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Public Health Social Sciences

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The Relationship between Antenatal Care Quality and Pregnancy Outcomes: Systematic Literature Review Panjarwanto, Dwi Andhika; Restalia, Fianda; Indrawan, I Wayan Agung; Utomo, Rudi Priyo; Permana, Adin Yan
JURNAL INFO KESEHATAN Vol 22 No 4 (2024): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol22.Iss4.1595

Abstract

This study investigates the correlation between the quality of prenatal care and pregnancy outcomes through a comprehensive literature review. The systematic literature review aims to elucidate the relationship between prenatal care quality and pregnancy outcomes while identifying key factors influencing care quality. Relevant studies were identified through an extensive search of databases, including Google Scholar, ScienceDirect, and PubMed, using specific keywords related to antenatal care quality, serum levels, and pregnancy outcomes. Articles published within the last ten years were screened based on inclusion criteria, resulting in 12 original studies selected for detailed analysis. The findings reveal a statistically significant correlation between prenatal care quality and pregnancy outcomes. Inadequate prenatal care was associated with a higher risk of preterm birth, low birth weight, and complications during delivery. Socioeconomic factors such as income level, education, and access to healthcare services were identified as critical determinants of prenatal care quality. This study highlights the urgent need to enhance the accessibility, continuity, and quality of prenatal care to reduce maternal and neonatal mortality and morbidity, particularly in resource-limited settings. Policy implications suggest the necessity of targeted interventions to address disparities in prenatal care, including improving healthcare infrastructure, training healthcare providers, and implementing community-based programs. In conclusion, the study underscores the pivotal role of high-quality antenatal care in ensuring favorable pregnancy outcomes. Tackling socioeconomic barriers and enhancing service delivery are crucial to reducing adverse outcomes and promoting maternal and child health. The findings call for policy reforms to strengthen antenatal care services, especially in underserved regions, to achieve better health outcomes for mothers and infants.
Investigating the Relationship Between Immunohistochemical Expression of CA 125 in Ovarian Epithelial Tumors and Serum Levels as Diagnostic Indicators Restalia, Fianda; Panjarwanto, Dwi Andhika; Sudarwantono, Johannes; Suseno, Daniel Alexander; Indrawan, I Wayan Agung
Interdiciplinary Journal and Hummanity (INJURITY) Vol. 4 No. 11 (2025): Injuruty: Interdiciplinary Journal and Humanity
Publisher : Pusat Publikasi Nusantara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58631/injurity.v4i11.1495

Abstract

This systematic literature review evaluates the relationship between CA-125 immunohistochemical expression in ovarian epithelial tumors and serum CA-125 levels as diagnostic indicators. Five studies meeting inclusion criteria from 20,500 initially identified articles consistently demonstrated significant positive correlations between tissue expression intensity and serum concentrations. Key findings reveal that elevated preoperative serum levels correspond directly with increased tissue expression intensity, while combined assessment improves diagnostic accuracy. Both parameters effectively predict early recurrence in advanced-stage (III/IV) disease and show distinct variation across histological subtypes, with mucinous carcinomas exhibiting the lowest expression levels. However, methodological limitations, including heterogeneous study designs, varying immunohistochemical techniques, and restricted sample sizes, affect generalizability. Clinical implications support integrating tissue immunohistochemistry with serum measurements and complementary biomarkers like HE4 for enhanced subtype differentiation. Future multicenter prospective studies with standardized protocols are recommended to establish definitive cut-off values and long-term prognostic significance. These findings underscore CA-125’s enduring clinical value while emphasizing that optimal diagnostic performance requires contextual interpretation alongside other markers, histological classification, and comprehensive patient assessment. The systematic PRISMA-guided approach ensured rigorous evidence synthesis, highlighting CA-125’s crucial role in addressing ovarian cancer’s significant global burden through improved early detection strategies.
Co-Authors I Wayan Agung Indrawan Panjarwanto, Dwi Andhika Permana, Adin Yan Sudarwantono, Johannes Suseno, Daniel Alexander Utomo, Rudi Priyo