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All Journal Jurnal Kedokteran Brawijaya Medical Journal of Indonesia Majalah Kesehatan FKUB Journal of Islamic Medicine CRJIM (Clinical and Research Journal in Internal Medicine) Jurnal Penyakit Dalam Indonesia
Sasiarini, Laksmi
Fakultas Kedokteran Universitas Brawijaya
Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Journal : Jurnal Penyakit Dalam Indonesia

 1 
Correlation of Ramadan Fasting with HbA1C and Lipid ProfileLevel Changes in The Risk Stratification of Complications inDiabetes Mellitus Patients Bramantya, Rinadhi Reza; Arsana, Putu Moda; Sasiarini, Laksmi
Jurnal Penyakit Dalam Indonesia Vol. 8, No. 1
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Introduction. Diabetic patients will still do Ramadan fasting, which could affect the levels of HbA1C and lipid change after Ramadan. This study aimed to identify the correlation between fasting of Ramadan risk stratification with HbA1C and lipid levels diabetic patients who run the fast of Ramadan. Methods. This was a survey research using pre - post test. Study was conducted among diabetes patients who meet the criteria: carry out routine controls before and after Ramadan fasting at dr. Saiful Anwar Malang Hospital, filling in the required data, and underwent examination laboratory. Patients were grouped into moderate, high, and very high-risk stratification. Then we analyzed the HbA1C and fat levels before (pre) and after (post) Ramadan fasting in each risk group. Results. There were 25 subjects included in this study. There was a decrease in HbA1C level in all subjects from 7.93% (SD 2.3) to 7.86% (SD 1.9) after Ramadan fasting (p = 0.563), only the moderate risk group increased by 0,37% (SB 0.27). In all subjects, total cholesterol levels increased from 196.4 (SD 48.7) mg/dl to 205.0 (SB 70.8) mg/dl (p = 0.397), with the highest change found in the very high-risk group with an increase 30,7 (SD 125.0) mg/dl. There was a decrease in HDL levels from 55.6 (SD 31.3) mg/dl to 47.8 (SD 10.5) mg/dl (p = 0.782), and the highest decrease occurred in the very high - risk group (27.7 (SD 66,9) mg / dl). There was an increase in the LDL from 115.9 (SD 45.8) mg/dl to 130.4 (SD 41.9) mg/dl (p = 0.133) which the highest increase found in the very high-risk group (55.0 (SD 74.7) mg/dl). Only triglycerides showed an improvement from 190.7 (SD 105.2) mg/dl to 188.8 (SD 79.6) mg/dl (p = 0.084), increasement only occur in the high risk group (13.2 (SD 213.4) mg/dl). Conclusion. There was a decrease in HbA1C levels, but the value of the statistics was not significant. There was a negative effect of fasting Ramadan against blood-fat levels, except for improvements in the levels of triglycerides though statistically not significant
A Case Series Hemichorea-Hemiballism Syndrome Related toNonketotic Hyperglycemia: A Challenge to Diagnostic Process Sasiarini, Laksmi; Budianto, Rahmad; Tarigan, Ricky C.
Jurnal Penyakit Dalam Indonesia Vol. 6, No. 1
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Diabetes mellitus is quite familiar to health-care personnel but occasionally presents with unusual manifestations. One of them is hemichorea-hemiballismus syndrome, a spectrum of involuntary, continuous non-patterned movement involving one side of the body which is related to nonketotic hyperglycemia in uncontrolled diabetes. Here we present two cases of nonketotic hyperglycemic diabetic patients who presented with the hemichorea-hemiballismus syndrome. First – a 57 years old woman was presented with involuntary, arrhythmic, and repetitive movement on the right arm and leg, accompanied by twitching on the right face for two weeks. She had an uncontrolled history of diabetes mellitus. The second- a 60 years old man was presented with recurrent general tonic-clonic seizure for about four days. The history of diabetes was unknown. Initial diagnosis on admission was general tonic-clonic seizure due to thrombotic cerebrovascular accident (CVA). Intravenous diazepam did not give any response to the seizures. Their brain CT scan imaging showed non-enhancing hyperdensities in the basal ganglia due to non-ketotic hyperglycemia, but the lesion was more extensive on the second patient. An involuntary movement was resolved after achieving blood glucose target by rehydration and continuous intravenous insulin therapy. Clinical response in these cases were reversible while the hyperdensities lesion will be persistent for a few months.
The Effect of Green Tea Extract Supplementation on PlasmaMalondialdehyde (MDA) in Human with Sub-Maximal PhysicalActivity, Double-Blind and Placebo-Controlled Trials Arsana, Putu Moda; Sasiarini, Laksmi; Nugraha, Bayu Eka
Jurnal Penyakit Dalam Indonesia Vol. 6, No. 1
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Introduction. Green Tea extract has been proven in vitro to have the ability as an antioxidant. Submaximal physical activity causes an increase in free radicals. The increase of MDA can detect the increase of free radicals. This study aimed to determine the effects of green tea extract supplementation against free radicals in submaximal physical activity by measuring plasma MDA. Methods. This double-blind controlled trial study was performed in 20 students of faculty of sports science with submaximal physical activity in the form of 1,500 meters running in 12 minutes using a treadmill. Subjects were divided into two groups: green tea extract group (250 mg) and the control group (placebo). Supplement/placebo was given as one caps a day for fourteen days before submaximal physical activity. The plasma MDA was taken before, 2 hours after, and 48 hours after the submaximal physical activity. Analysis of the results used ANOVA and post hoc Tukey. The study has been assessed by 24 | Jurnal Penyakit Dalam Indonesia | Vol. 6, No. 1 | Maret 2019 Putu Moda Arsana, Laksmi Sasiarini, Bayu Eka Nugraha Medical Research Ethical Committee at Medical Faculty of Universitas Brawijaya. Results. In the control group, the mean value of plasma MDA levels in basal conditions, 2 hours and 48 hours after submaximal physical activity were 52.43 nmol/ml (standard deviation [SD] 12.52 nmol/ml), 55.57 nmol/ml (SD 13.84 nmol/ml), and 63.86 nmol/ml (SD 12.17 nmol/ml), respectively. However, this result was not statistically significant (p = 0.158). In the treatment group, the mean value of plasma MDA level at 48 hours after submaximal physical activity was significantly decreased compared to basal condition with mean value in basal and 48 hours after submaximal physical activity were 36.14 nmol/ ml (SD 5.88 nmol/ml) and 19.86 nmol/ml (SD 8.92 nmol/ml), respectively (p <0.001). Further analysis showed a significant difference in plasma MDA levels between the two groups at basal, 2 hours, and 48 hours after submaximal physical activity (p values were 0.012; <0.001, and <0.001 respectively). Conclusion. Green tea extract can decrease the plasma level of MDA at basal, 2 hours, and 48 hours after submaximal physical activity.
Co-Authors Achmad Rudijanto Ahdi, Iwal Reza Arsana, Putu Moda Bayu Eka Nugraha Brahmantyo, Herwindo Pudjo Bramantya, Rinadhi Reza Budianto, Rahmad Cholid Tjahjono Chozin, Iin Noor Djoko Wahono Soeatmadji Indah Puji Lestari Iwal Reza Ahdi Novita Lavi Nugraha, Bayu Eka Nurshanty, Ade Puspitasari, Ika A Putu Moda Arsana Putu Moda Arsana Rahmad Budianto Ricky C. Tarigan Rinadhi Reza Bramantya Rulli Rosandi Santoso, Aktaruddin Arief Sartono, Teguh Rahayu Sasongko, Ardi Simatupang, Charisma Dian Sri Andarini Sri Sunarti Tarigan, Ricky C. Yudhanto, Hendy Setyo