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All Journal International Journal of Public Health Science (IJPHS) Medical and Health Science Journal CRJIM (Clinical and Research Journal in Internal Medicine) Unram Journal of Community Service (UJCS) Medicosphere
Santoso, Aktaruddin Arief
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Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Other

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The Impact of Subchronic Soybean Milk and Genistein Supplementation on Pancreatic Fatty Infiltrations of Sprague Dawley Male Mice Sasiarini, Laksmi; Soeatmadji, Djoko Wahono; Santoso, Aktaruddin Arief
Clinical and Research Journal in Internal Medicine Vol 1, No 2 (2020): New: The Second Issue is Coming!
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.crjim.2020.001.02.4

Abstract

Isoflavones (genistein, daidzein) on soybean milk have phytoestrogenic properties. In Asia, the blood phytoestrogen levels can reach 160 ng/ml (80 times higher than Western). This may potentially disrupt endocrine functions regarding its binding with estrogen receptors.. Since the function and distribution of adipose tissues are regulated by estrogen receptors, the reduction of estrogen receptor-α(ERα) results in ectopic fats distribution around visceral tissues, such as the pancreas. Aim: To investigate the impact of subchronic soybean milk and genistein supplementation on pancreatic fatty infiltrations in mice. Methods: The experiment used 35 Sprague dawley male mice under 7 treatment groups within 60 days: negative control with standard rationed food, 3 groups with a variable dose of soybean milk: 100 mg, 200 mg, and 400 mg, and 3 groups with a variable dose of genistein: 0.4 mg, 0.8 mg, and 1.6 mg. Histological measurements on the level of pancreatic fatty infiltrations were conducted after. Analyses used Kruskal-Wallis and post-hoc Mann-Whitney. Results: Medium to a high level of pancreatic fatty infiltrations were found at the control group while there is a decreasing trend on the level of pancreatic fatty infiltrations on groups with soybean milk and subchronic genistein compared with the control group, proportional to higher dosage supplementation. The reduction of pancreatic fatty infiltration levels on groups with soybean milk and subchronic genistein supplementation is not statistically significant compared to control. Conclusion:  Supplementation of soybean milk and subchronic genistein do not significantly reduce the levels of pancreatic fatty infiltrations in Sprague dawley male mice.
Irritable bowel syndrome following infectious COVID-19: East Java, Indonesia, 2023 Hanum, Aisyah Rizki Nirmala; Illahika, Anung Putri; Santoso, Aktaruddin Arief; Putra, Probo Yudha Pratama
International Journal of Public Health Science (IJPHS) Vol 13, No 2: June 2024
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v13i2.23547

Abstract

Irritable bowel syndrome (IBS) is a functional disorder that causes chronic abdominal pain without a known cause. It is a common, chronic gastrointestinal (GI) motility disorder with bothersome symptoms that often lower quality of life and activity. In addition, Patients and healthcare facilities also face significant financial costs. COVID-19 directly damages the digestive system and alters the complex interaction of physical, mental, and social factors that cause digestive problems. SARS-CoV-2 survivors in personal isolation will be examined for IBS prevalence. The dates of this descriptive cross-sectional study are January through April 2023. Rome IV criteria and an online questionnaire were used to confirm the diagnosis of IBS. The principal location where polls have been sent is East Java, Indonesia. The 96 COVID-19 survivors aged 18–60 of both genders was included during self-quarantine. There were 59 females (61.46%) and 37 males (38.54%). The prevalence of IBS was discovered to be 19 (19.79%) among a total of 96 patients. This could be because self-quarantined people have more stable living conditions than hospitalized people. Based on these findings, it is suggested that future research consider gender as the primary proxy for identifying irritable bowel syndrome (IBS).
Relationship Between Health-Related Quality of Life (HRQoL) Factors in Patients With Diabetes Mellitus : A Literature Review Satyafebrianti, Kendra Callista; Santoso, Aktaruddin Arief
Journal of Diverse Medical Research: Medicosphere Vol. 2 No. 3 (2025): J Divers Med Res 2025
Publisher : Faculty of Medical - UPN Veteran Jawa Timur

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Abstract

Background: Diabetes mellitus (DM) is a chronic disease that can significantly affect the quality of life of patients. Poor quality of life is often associated with poor disease control, complications, and psychosocial burden. A better understanding of the factors that affect the quality of life of DM patients is essential for designing effective interventions. Objective: This study aims to analyze the relationship between health-based quality of life factors and the condition of diabetes mellitus patients. Method: This study used a literature review method. Researchers collect data through database sources, such as PubMed, Google Scholar, and ScienceDirect. The articles used are in English. The keywords used in the article search are: "heart related quality of life" and "diabetes mellitus". The article search is limited to publications in the last 5 years (2019 to 2024). Results: The results showed that factors such as glycemic control, severity of complications, social support, and depression were significantly associated with the quality of life of patients. Patients with better glycemic control and higher social support reported better quality of life. Conclusion: Overall, the quality of life of diabetes mellitus patients is greatly influenced by various factors, including glycemic control, complications, social support, and psychosocial factors. To improve the quality of life of diabetes patients, it is important to provide a holistic approach that includes good medical management, emotional support, and social interventions that can improve their well-being.
Implementing a Dual Screening Protocol for Diabetes and Frailty in a Community-Dwelling Older Adults Ardian, Laurentius Johan; Santoso, Aktaruddin Arief; Fahma, Hilmia; Gusyono, Anoraga Mona Cinta Gadis Cantika; Verbimanto, Satria Fudi
Unram Journal of Community Service Vol. 6 No. 3 (2025): September
Publisher : Pascasarjana Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/ujcs.v6i3.1157

Abstract

Frailty, a significant geriatric syndrome, is a major complication of diabetes and is associated with adverse health outcomes. Indonesia, with its rapidly aging population, faces a substantial burden from these conditions. Community-based screening is essential for early detection and intervention. A community engagement program was conducted in Gunung Anyar District, Surabaya, involving 189 elderly participants. Simultaneous screenings for diabetes (via random blood glucose test) and frailty (using the validated FRAIL questionnaire) were performed. The study revealed a high dual burden of disease: 42.0% of participants had blood glucose levels indicative of diabetes, while 11.6% were classified as frail and 39.7% as pre-frail. About 30% of them were both unfit and poor glycemic control. This program demonstrates a high prevalence of diabetes and frailty among community-dwelling older adults in Surabaya, underscoring the urgent need for integrated geriatric care. The successful implementation of dual screening highlights the feasibility of incorporating these measures into primary care and the critical role of training community health workers to enable sustainable, early detection and management strategies.
Improving Diabetic Neuropathy Knowledge in an Urban Elderly Population: A Community-Based Intervention Study Ardian, Laurentius Johan; Santoso, Aktaruddin Arief; Fahma, Hilmia; Gusyono, Anoraga Mona Cinta Gadis Cantika; Verbimanto, Satria Fudi
Jurnal Ilmu Kesehatan dan Kesehatan Vol 9 No 2 (2025): AUGUST
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v9i2.7974

Abstract

Background: The global population is aging rapidly, with older adults increasingly affected by chronic conditions such as diabetes mellitus. In Indonesia, diabetes among the elderly poses a significant public health concern, often complicated by under-recognized conditions like diabetic neuropathy. Aim: This study aimed to assess the effectiveness of a community-based intervention focused on targeted health education on diabetic neuropathy among elderly residents in urban area. Methods: A pre- and post-test design was used to assess the intervention's effectiveness. In collaboration with local health cadres and facilities, participants completed identical questionnaires on diabetic neuropathy before and after the health education session to measure improvements in knowledge. Results: A total of 143 elderly participants (median age: 65 years) were enrolled, with 73.4% being female. Post-education test scores showed a statistically significant improvement compared to pre-test scores (p<0.001p<0.001, Wilcoxon test). Of the participants, 22.4% were newly identified as having diabetes, and another 22% fell into the prediabetes range. Despite some variations in learning outcomes, 84.6% showed improved scores, indicating high effectiveness of the health education session. Conclusion: This study demonstrates that a community-based approach combining early diabetes screening and health education significantly improves elderly participants' knowledge about diabetes and diabetic neuropathy.
Co-Authors Anung Putri Illahika Ardian, Laurentius Johan Djoko Wahono Soeatmadji Fahma, Hilmia Gusyono, Anoraga Mona Cinta Gadis Cantika Hanum, Aisyah Rizki Nirmala Putra, Probo Yudha Pratama Sasiarini, Laksmi Satyafebrianti, Kendra Callista Verbimanto, Satria Fudi