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Indriani, Fenita
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Factors Affecting Mortality in People Living with HIV with Antiretroviral Therapy: A Meta-Analysis Anindita, Fauziah Shinta; Indriani, Fenita; Murti, Bhisma; Veibiani, Nindita Arum
Journal of Epidemiology and Public Health Vol. 9 No. 4 (2024)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/jepublichealth.2024.09.04.08

Abstract

Background: TB is the leading cause of death among people living with HIV. In 2020, an estimated 214,000 people living with HIV died from TB. People with AIDS have a severely damaged immune system. They are increasingly suffering from severe diseases, called opportunistic infections (OI). This study aims to analyze and estimate the influence of gender, TB Coinfection, Opportunistic Infection on mortality in ODHIV with Antiretroviral Therapy.Subjects and Method: Systematic review and meta-analysis using PRISMA flowchart and the PICO model. Population: ODHIV with ART. Intervention: Women, Co-infected TB, Opportunistic Infections. Comparison: Male, no co-infected TB, no Opportunistic Infection. Outcome: Mortality Article search using Google Scholar, PubMed and Science Direct databases. The keywods used include "HAART" or "HIV" or "HIV/AIDS" and "Gender" and "TB Coinfections" or "TB" and "Opportunistic Infections" and "Mortality" and "Antiretroviral Treatment". The 17 included articles are fulltext in English with a cohort design study from 2008 to 2023 and report on the Hazard Ratio in a multivariate analysis. Data analysis using the RevMan 5.3 application.Results: A total of 17 cohort studies involving 23,651 research subjects from Vietnam, China, Japan, Ethiopia, and South Africa. The data collected showed that female ODHIV had a mortality risk of 0.7 times compared to male ODHIV (aHR= 0.70; CI 95%=0.60 to 0.79; p<0.001). In ODHIV with coinfected TB has a mortality risk of 1.86 times compared to ODHIV without coinfected TB (aHR= 1.89; CI 95%=1.36 to 2.61; p<0.001). ODHIV with Opportunistic Infection has a 1.90-fold risk of mortality compared to ODHIV without Opportunistic Infection (aHR= 1.90; CI 95%=1.50 to 2.42; p<0.001).Conclusion: Female gender decreases the risk of mortality, while TB coinfection and Opportunistic infection increase the risk of mortality in ODHIV with Antiretroviral Therapy.
Factors Associated with Dyslipidemia among Workers: A Path Analysis Indriani, Fenita; Sumardiyono; Murti, Bhisma; Demartoto, Argyo
Journal of Epidemiology and Public Health Vol. 10 No. 1 (2025)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/jepublichealth.2025.10.05.02

Abstract

Background: The results of the 2023 Indonesian Health Survey show that 39.5% of the Indonesian population aged ≥ 15 years old have abnormal total cholesterol levels. Dyslipidemia or plasma lipid abnormalities play a major role in the pathogenesis of atherosclerosis on the walls of blood vessels which is the cause of coronary heart disease (CHD) and stroke. The purpose of the study was to analyze the factors that affect dyslipidemia in workers.Subjects and Method: This study uses an analytical observational design using a cross-sectional approach. The study was conducted at the Yogyakarta Labkesmas Center in October 2024 with a total of 150 worker study subjects. The sampling technique is non-probability sampling, namely total sampling. The independent variables in this study were BMI, glucose levels, stress, and depression while the dependent variables were total cholesterol levels. Data collection was carried out using secondary data and questionnaires, the data was analyzed by path analysis.Results: Each increase of one mg/dL of glucose level (b = 0.24; CI 95%= 0.09 to 0.39; p = 0.002) and one unit of depression (b = 0.16; CI 95%= 0.01 to 0.31; p= 0.043) will be followed by an increase in total cholesterol levels. Any increase in BMI through a mediator of glucose levels and stress through a mediator of depression will be followed by an increase in total cholesterol levels.Conclusion: Total cholesterol levels increase with increased glucose levels and depression levels. Total cholesterol levels are indirectly affected by BMI through glucose level mediators and stress levels through depression mediators.  
Factors Affecting Mortality in People Living with HIV with Antiretroviral Therapy: A Meta-Analysis Anindita, Fauziah Shinta; Indriani, Fenita; Murti, Bhisma; Veibiani, Nindita Arum
Journal of Epidemiology and Public Health Vol. 9 No. 4 (2024)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/jepublichealth.2024.09.04.08

Abstract

Background: TB is the leading cause of death among people living with HIV. In 2020, an estimated 214,000 people living with HIV died from TB. People with AIDS have a severely damaged immune system. They are increasingly suffering from severe diseases, called opportunistic infections (OI). This study aims to analyze and estimate the influence of gender, TB Coinfection, Opportunistic Infection on mortality in ODHIV with Antiretroviral Therapy.Subjects and Method: Systematic review and meta-analysis using PRISMA flowchart and the PICO model. Population: ODHIV with ART. Intervention: Women, Co-infected TB, Opportunistic Infections. Comparison: Male, no co-infected TB, no Opportunistic Infection. Outcome: Mortality Article search using Google Scholar, PubMed and Science Direct databases. The keywods used include "HAART" or "HIV" or "HIV/AIDS" and "Gender" and "TB Coinfections" or "TB" and "Opportunistic Infections" and "Mortality" and "Antiretroviral Treatment". The 17 included articles are fulltext in English with a cohort design study from 2008 to 2023 and report on the Hazard Ratio in a multivariate analysis. Data analysis using the RevMan 5.3 application.Results: A total of 17 cohort studies involving 23,651 research subjects from Vietnam, China, Japan, Ethiopia, and South Africa. The data collected showed that female ODHIV had a mortality risk of 0.7 times compared to male ODHIV (aHR= 0.70; CI 95%=0.60 to 0.79; p<0.001). In ODHIV with coinfected TB has a mortality risk of 1.86 times compared to ODHIV without coinfected TB (aHR= 1.89; CI 95%=1.36 to 2.61; p<0.001). ODHIV with Opportunistic Infection has a 1.90-fold risk of mortality compared to ODHIV without Opportunistic Infection (aHR= 1.90; CI 95%=1.50 to 2.42; p<0.001).Conclusion: Female gender decreases the risk of mortality, while TB coinfection and Opportunistic infection increase the risk of mortality in ODHIV with Antiretroviral Therapy.
Factors Associated with Dyslipidemia among Workers: A Path Analysis Indriani, Fenita; Sumardiyono; Murti, Bhisma; Demartoto, Argyo
Journal of Epidemiology and Public Health Vol. 10 No. 1 (2025)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/jepublichealth.2025.10.05.02

Abstract

Background: The results of the 2023 Indonesian Health Survey show that 39.5% of the Indonesian population aged ≥ 15 years old have abnormal total cholesterol levels. Dyslipidemia or plasma lipid abnormalities play a major role in the pathogenesis of atherosclerosis on the walls of blood vessels which is the cause of coronary heart disease (CHD) and stroke. The purpose of the study was to analyze the factors that affect dyslipidemia in workers.Subjects and Method: This study uses an analytical observational design using a cross-sectional approach. The study was conducted at the Yogyakarta Labkesmas Center in October 2024 with a total of 150 worker study subjects. The sampling technique is non-probability sampling, namely total sampling. The independent variables in this study were BMI, glucose levels, stress, and depression while the dependent variables were total cholesterol levels. Data collection was carried out using secondary data and questionnaires, the data was analyzed by path analysis.Results: Each increase of one mg/dL of glucose level (b = 0.24; CI 95%= 0.09 to 0.39; p = 0.002) and one unit of depression (b = 0.16; CI 95%= 0.01 to 0.31; p= 0.043) will be followed by an increase in total cholesterol levels. Any increase in BMI through a mediator of glucose levels and stress through a mediator of depression will be followed by an increase in total cholesterol levels.Conclusion: Total cholesterol levels increase with increased glucose levels and depression levels. Total cholesterol levels are indirectly affected by BMI through glucose level mediators and stress levels through depression mediators.  
Co-Authors Anindita, Fauziah Shinta Argyo Demartoto, Argyo Bhisma Murti Sumardiyono Veibiani, Nindita Arum