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Charoensup, Nathirat
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Biochemistry, Genetics & Molecular Biology Chemistry Medicine & Pharmacology Nursing Public Health

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Cissus quadrangularis in Bone Healing and Oxidative Stress Charoensup, Nathirat; Sangthong, Kittisak; Kongcharoen, Watis
Journal of Advances in Medicine and Pharmaceutical Sciences Vol 3 No 1: May 2024
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.jamaps-0301.585

Abstract

Cissus quadrangularis is a plant known for its traditional use in bone healing, has shown potential in modern pharmacological applications due to its bioactive compounds. This study investigates the therapeutic effects of Cissus quadrangularis extract on bone healing, antioxidant activity, and gastric protection. The primary objective was to evaluate its efficacy in accelerating bone regeneration, mitigating oxidative stress, and protecting the gastric mucosa from NSAID-induced damage. The methodology involved a series of in vivo experiments using rats, with treatment groups receiving the extract and control groups given a placebo. Bone healing was assessed radiographically, antioxidant activity was measured using the DPPH assay and SOD enzyme activity, and gastric protection was evaluated by counting gastric lesions. The findings revealed a 40% improvement in bone healing, a 25% increase in SOD activity, and a 60% reduction in gastric lesions in the treatment group compared to controls. These results suggest that Cissus quadrangularis has significant potential as a natural remedy for bone fractures, oxidative stress, and gastric ulcers. Future research should focus on human clinical trials, molecular mechanisms, and long-term safety to support its broader medical application.
Antihyperglycemic Effect of Gymnema inodorum in Type 2 Diabetes Management Kongcharoen, Watis; Jaturaporn, Ananya; Chavalit, Kittisak; Charoensup, Nathirat
Journal of Advances in Medicine and Pharmaceutical Sciences Vol 3 No 1: May 2024
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.jamaps-0301.686

Abstract

This study investigates the antihyperglycemic effects of Gymnema inodorum (Chiang Da), a traditional medicinal plant from northern Thailand, commonly used for managing blood glucose levels. The goal was to evaluate its pharmacological effects, including the inhibition of alpha-glucosidase and its ability to lower blood glucose levels in Type 2 diabetic rats. Ethanol maceration was used to extract bioactive compounds from Chiang Da leaves, yielding gymnemic acids, saponins, and flavonoids. The in vivo study involved administering Chiang Da tea to diabetic rats for 8 weeks, measuring fasting and postprandial blood glucose levels. Results showed a significant reduction in blood glucose levels in the Chiang Da-treated group, comparable to the synthetic drug metformin. In vitro tests also revealed the extract’s concentration-dependent inhibition of alpha-glucosidase, with an IC50 value of 45 µg/mL, indicating moderate potency in delaying glucose absorption. Descriptive and inferential statistics confirmed that Chiang Da tea significantly reduced blood glucose levels, though its effects were less pronounced than metformin’s. These findings support the potential of Chiang Da as a natural alternative for managing Type 2 diabetes, particularly for individuals seeking plant-based treatments. Future research should focus on clinical trials to further evaluate the efficacy and safety of Chiang Da for diabetes management, as well as explore its potential for combination therapy with conventional drugs to enhance therapeutic outcomes.
Evaluating the Effectiveness of Thai Basil Extract in Managing Type 2 Diabetes Charoensup, Nathirat; Ruksiriwanich, Loryuenyong; Juruwan, Maneeton
Journal of Advances in Medicine and Pharmaceutical Sciences Vol 3 No 2: November 2024
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.jamaps-0302.584

Abstract

This study investigated the potential of Ocimum basilicum var. thyrsiflora (Thai basil) extract as a natural adjunct therapy for the management of type 2 diabetes. The increasing prevalence of diabetes globally and the limitations of conventional therapies require alternative approaches, especially in regions where Thai basil is culturally accepted. The objective was to evaluate the effects of Thai basil on blood glucose levels and glycemic control in patients with type 2 diabetes. A randomized controlled trial was conducted in 2024 with 200 participants, aged 30–65 years, diagnosed with type 2 diabetes. Participants were assigned to either the Thai basil extract group (500 mg daily) or the placebo group, with clinical data collected at baseline, mid-intervention, and post-intervention. Findings showed that the intervention group experienced significant reductions in fasting blood glucose and HbA1c levels, indicating improved long-term glycemic control. In addition, lipid profiles, including cholesterol and triglyceride levels, were positively affected. However, no significant weight loss was observed. This review highlights the therapeutic potential of Thai basil bioactive compounds, including flavonoids and essential oils, which have antioxidant, anti-inflammatory, and antidiabetic properties. Limitations such as sample size and study duration are noted, indicating the need for further studies with larger, more diverse populations and longer duration. Future studies should explore the optimal dosage, formulation, and long-term effects of Thai basil. This study supports the inclusion of Thai basil in diabetes care, especially in regions where basil is widely available and culturally accepted.
Co-Authors Chavalit, Kittisak Jaturaporn, Ananya Juruwan, Maneeton Kongcharoen, Watis Ruksiriwanich, Loryuenyong Sangthong, Kittisak