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All Journal Journal of Advances in Medicine and Pharmaceutical Sciences
Kongcharoen, Watis
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Biochemistry, Genetics & Molecular Biology Chemistry Medicine & Pharmacology Nursing Public Health

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Cissus quadrangularis in Bone Healing and Oxidative Stress Charoensup, Nathirat; Sangthong, Kittisak; Kongcharoen, Watis
Journal of Advances in Medicine and Pharmaceutical Sciences Vol 3 No 1: May 2024
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.jamaps-0301.585

Abstract

Cissus quadrangularis is a plant known for its traditional use in bone healing, has shown potential in modern pharmacological applications due to its bioactive compounds. This study investigates the therapeutic effects of Cissus quadrangularis extract on bone healing, antioxidant activity, and gastric protection. The primary objective was to evaluate its efficacy in accelerating bone regeneration, mitigating oxidative stress, and protecting the gastric mucosa from NSAID-induced damage. The methodology involved a series of in vivo experiments using rats, with treatment groups receiving the extract and control groups given a placebo. Bone healing was assessed radiographically, antioxidant activity was measured using the DPPH assay and SOD enzyme activity, and gastric protection was evaluated by counting gastric lesions. The findings revealed a 40% improvement in bone healing, a 25% increase in SOD activity, and a 60% reduction in gastric lesions in the treatment group compared to controls. These results suggest that Cissus quadrangularis has significant potential as a natural remedy for bone fractures, oxidative stress, and gastric ulcers. Future research should focus on human clinical trials, molecular mechanisms, and long-term safety to support its broader medical application.
Antihyperglycemic Effect of Gymnema inodorum in Type 2 Diabetes Management Kongcharoen, Watis; Jaturaporn, Ananya; Chavalit, Kittisak; Charoensup, Nathirat
Journal of Advances in Medicine and Pharmaceutical Sciences Vol 3 No 1: May 2024
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.jamaps-0301.686

Abstract

This study investigates the antihyperglycemic effects of Gymnema inodorum (Chiang Da), a traditional medicinal plant from northern Thailand, commonly used for managing blood glucose levels. The goal was to evaluate its pharmacological effects, including the inhibition of alpha-glucosidase and its ability to lower blood glucose levels in Type 2 diabetic rats. Ethanol maceration was used to extract bioactive compounds from Chiang Da leaves, yielding gymnemic acids, saponins, and flavonoids. The in vivo study involved administering Chiang Da tea to diabetic rats for 8 weeks, measuring fasting and postprandial blood glucose levels. Results showed a significant reduction in blood glucose levels in the Chiang Da-treated group, comparable to the synthetic drug metformin. In vitro tests also revealed the extract’s concentration-dependent inhibition of alpha-glucosidase, with an IC50 value of 45 µg/mL, indicating moderate potency in delaying glucose absorption. Descriptive and inferential statistics confirmed that Chiang Da tea significantly reduced blood glucose levels, though its effects were less pronounced than metformin’s. These findings support the potential of Chiang Da as a natural alternative for managing Type 2 diabetes, particularly for individuals seeking plant-based treatments. Future research should focus on clinical trials to further evaluate the efficacy and safety of Chiang Da for diabetes management, as well as explore its potential for combination therapy with conventional drugs to enhance therapeutic outcomes.
Co-Authors Charoensup, Nathirat Chavalit, Kittisak Jaturaporn, Ananya Sangthong, Kittisak