Background: The escalating number of COVID-19-positive cases and mortality within the community has prompted the government to prioritize vaccination efforts. However, the vaccination target has not yet reached optimal, particularly in Palembang. This study aims to evaluate the implementation of the COVID-19 vaccination program at the Community Health Center in Palembang through a descriptive qualitative approach. Subjects and Method: The data were obtained through in-depth interviews, observations, and document reviews conducted at the Community Health Center between November 25, 2021, and December 30, 2021. A total of ten informants were selected using consecutive sampling. Results: The findings of this study indicate consistency in various aspects of the input component, including the vaccine team, funding sources, types of vaccines, storage facilities, other support systems, and planning methods. However, due to a lack of data integration among the data management entities, the Community Health Center and Health Office face challenges in accurately determining vaccine targets. The vaccination coverage in Palembang stood at 87.08% for the first dose and 68.52% for the second dose. Unfortunately, delays in achieving vaccine coverage, particularly among specific groups such as older people, have hindered the development of expected herd immunity. There have been no reports of severe adverse events following immunization (AEFIs) within the community. Conclusion: The COVID-19 vaccination program in Palembang was implemented well. However, data management entities must prioritize data integration to fulfill vaccination targets.