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All Journal HAYATI Journal of Biosciences Jurnal Veteriner dan Biomedis
Rayendra, Raendi
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Immunology & microbiology Medicine & Pharmacology Veterinary

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Potensi Tanaman Alpukat (Persea americana Mill) dalam Bidang Dermatologi Sebayang, Shalina; Rayendra, Raendi; Wientarsih, Ietje; Priosoeryanto, Bambang Pontjo
Jurnal Veteriner dan Biomedis Vol. 2 No. 2 (2024): September
Publisher : Sekolah Kedokteran Hewan dan Biomedis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jvetbiomed.2.2.79-85.

Abstract

Penggunaan obat tradisional yang berasal dari tanaman dapat menjadi alternatif untuk mengatasi masalah kulit. Tanaman alpukat (Persea americana Mill.) diketahui memiliki banyak khasiat karena mengandung flavonoid, saponin, tannin, alkaloid, steroid, dan fenol yang merupakan antioksidan yang berperan dalam menangkal radikal bebas, sehingga dapat digunakan sebagai alternatif terapi pada beberapa kelainan kulit, serta menjaga kualitas dan penampilan kulit. Metode yang digunakan oleh penulis adalah kajian literatur dari jurnal nasional maupun internasional. Artikel dan jurnal yang didapat dibaca, ditelaah dan dianalisis untuk memberikan informasi baru yang relevan. Hasil penelusuran didapatkan bahwa tanaman alpukat, baik dari daging buah, daun, biji dan kulit memiliki khasiat dalam bidang dermatologi, diantaranya yaitu sebagai antibakteri pada antijerawat, antijamur, tabir surya, agen pemutih, pelembab kulit, dan antiaging. Dapat disimpulkan bahwa tanaman alpukat dapat digunakan sebagai alternatif untuk mengatasi berbagai masalah kulit, walaupun masih harus dilakukan penelitian lebih lanjut untuk menggali lebih banyak manfaat lain dari tanaman alpukat dalam bidang dermatologi. Kata kunci: Alpukat, Persea americana Mill, dermatologi.
Cytotoxicity of Ethyl Acetate Extract of Avocado Seeds (Persea americana Mill.) on Mouse Melanoma B16F10 Cell Line Sebayang, Shalina; Mariya, Silmi; Rayendra, Raendi; Wientarsih, Ietje; Priosoeryanto, Bambang Pontjo
HAYATI Journal of Biosciences Vol. 32 No. 2 (2025): March 2025
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.32.2.405-413

Abstract

Artificial whitening agents available in the market can cause damage to melanocytes; therefore, a safe and naturally derived skin-whitening agent is needed. Avocado seeds (Persea americana Mill.) are often discarded as waste but possess numerous health benefits. One of the compounds in avocado seeds is catechin, a flavonoid metabolite. This compound has been reported to exhibit antioxidant activity and inhibit tyrosinase to prevent melanin formation, making it suitable for skin-whitening applications. This study aimed to conduct phytochemical screening, assess antioxidant activity using the DPPH method, analyze catechin content using HPLC, and perform cell viability tests using the MTT method from the ethyl acetate extract of avocado seeds. Phytochemical screening has revealed the presence of flavonoids, saponins, and steroids. The DPPH assay yielded an IC50 value of 89.47±0.73 ppm, indicating an intense antioxidant activity, and HPLC detected 0.09% catechin. The MTT test results yielded cell viability percentages ranging from 80-100% at test concentrations of 0.75-25 ppm, with an IC50 value of 61.7 ppm. In conclusion, our results indicate that the ethyl acetate extract from avocado seeds affects cell viability without toxicity, warranting further testing for tyrosinase inhibition in the mouse melanoma B16F10 cell line.
Evaluating the Cytotoxic Effects of Ethanol and n-Hexane Extracts from Black Cumin Seeds (Nigella sativa) on B16F10 Mouse Melanoma Cells : A Preliminary Investigation into Vitiligo Treatment Pratiwi, Dian; Mariya, Silmi; Rayendra, Raendi; Setiyono, Agus
HAYATI Journal of Biosciences Vol. 32 No. 1 (2025): January 2025
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.32.1.203-211

Abstract

Black cumin (Nigella sativa) is a herbal plant that has been cultivated locally in Indonesia and is traditionally used for various diseases. Thymoquinone, one of the main components, is rich in biological activity. In several countries, topical application of its oil on human skin with vitiligo can stimulate skin repigmentation with minimal side effects. This study aims to determine the viability of B16F10 melanoma mouse cells against ethanol and n-hexane extracts of black cumin seeds through the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The ethanol extract (EE) yield was 14.306%, and the n-hexane extract (NHE) was 7.442%. Phytochemical screening of EE detected flavonoids, alkaloids, saponins, and steroids, and High-performance liquid chromatography (HPLC) detected 0.040% thymoquinone. The MTT test showed cell viability was >100% from EE at all treatment concentrations, namely 0.75-100 ppm and only 0.75-6.25 ppm for NHE. In conclusion, this study indicates that 96% EE of Nigella sativa is less toxic than NHE on B16F10 mouse melanoma cells and has potential as an alternative treatment for vitiligo, which needs to be proven in further research.
Co-Authors Agus Setiyono Bambang Pontjo Priosoeryanto Dian Pratiwi IETJE WIENTARSIH Sebayang, Shalina SILMI MARIYA