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All Journal Journal of Food and Pharmaceutical Science Journal of Food and Pharmaceutical Sciences
Sudarma, I Wayan Ari
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience

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SARS-CoV-2 Oral Vaccine Design Based on Nanoparticle Encapsulation with a Combination of Chitosan and Alginate Cista Dewi, Ni Putu Fiona; Amelia Putri, Ni Luh Dian Saptari; Sudarma, I Wayan Ari; Sang Ayu Putu Chika Iswari Anjani; Saputra, Gusti Nyoman Oka; Yowani, Sagung Chandra
Journal of Food and Pharmaceutical Sciences Vol 12, No 3 (2024): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.15290

Abstract

Vaccination is the most effective intervention in reducing mortality rates due to COVID-19. Oral vaccines provide a more convenient process with a dual immune response (systemic and mucosal). Encapsulation is a strategic method that can be used to enhance the efficiency of oral vaccines. The combination of chitosan and alginate can protect the drug from gastrointestinal disturbances. Our research aims to nanoencapsulate the intravenous vaccine "Inavac" using chitosan and alginate polymers into a vaccine that can be consumed orally. The optimal formulation obtained is a formula with 1.75% chitosan; 0.1% NaTPP; and 0.05% alginate, with a stirring speed of 1150 rpm and a duration of 60 minutes. Characterization results show that the nanoencapsulated COVID-19 vaccine formula is nanometer-sized with homogeneous distribution and system stability correlated with good mucoadhesive power. Good design stability is indicated by the absence of significant changes in the formula levels (p-value = 0.69), appropriate functional groups, spherical surface morphology, and the highest vaccine release in the intestine (Simulated Intestine Fluid media). Optimum Formula Oral SARS-CoV-2 vaccine with chitosan and alginate polymers has great potential to be developed so that it can be an alternative choice for the community.
SARS-CoV-2 Oral Vaccine Design Based on Nanoparticle Encapsulation with a Combination of Chitosan and Alginate Cista Dewi, Ni Putu Fiona; Amelia Putri, Ni Luh Dian Saptari; Sudarma, I Wayan Ari; Sang Ayu Putu Chika Iswari Anjani; Saputra, Gusti Nyoman Oka; Yowani, Sagung Chandra
Journal of Food and Pharmaceutical Sciences Vol 12, No 3 (2024): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.15290

Abstract

Vaccination is the most effective intervention in reducing mortality rates due to COVID-19. Oral vaccines provide a more convenient process with a dual immune response (systemic and mucosal). Encapsulation is a strategic method that can be used to enhance the efficiency of oral vaccines. The combination of chitosan and alginate can protect the drug from gastrointestinal disturbances. Our research aims to nanoencapsulate the intravenous vaccine "Inavac" using chitosan and alginate polymers into a vaccine that can be consumed orally. The optimal formulation obtained is a formula with 1.75% chitosan; 0.1% NaTPP; and 0.05% alginate, with a stirring speed of 1150 rpm and a duration of 60 minutes. Characterization results show that the nanoencapsulated COVID-19 vaccine formula is nanometer-sized with homogeneous distribution and system stability correlated with good mucoadhesive power. Good design stability is indicated by the absence of significant changes in the formula levels (p-value = 0.69), appropriate functional groups, spherical surface morphology, and the highest vaccine release in the intestine (Simulated Intestine Fluid media). Optimum Formula Oral SARS-CoV-2 vaccine with chitosan and alginate polymers has great potential to be developed so that it can be an alternative choice for the community.
Co-Authors Amelia Putri, Ni Luh Dian Saptari Cista Dewi, Ni Putu Fiona Sagun Chandra Yowani Sang Ayu Putu Chika Iswari Anjani Saputra, Gusti Nyoman Oka