Article Per Year (5 Year)
p-Index From 2021 - 2026
0.444
P-Index
This Author published in this journals
All Journal JPSCR : Journal of Pharmaceutical Science and Clinical Research Indonesian Journal of Chemical Science
Hess, Aurelina Yunita
Unknown Affiliation
Chemistry Environmental Science Physics Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
In Silico Study of Active Compounds in Guava Leaves (Psidium guajava L.) toward Angiotensin Converting Enzyme (ACE) as target for hypertension Hess, Aurelina Yunita; Ramadhani, Siti Zhahira; Andhryanti, Rifa Nurfadila; Zhafirah, Noor; Muljono, Fajar Oktavian; Fardhan, Firghi Muhammad; Novitasari, Dhania
Indonesian Journal of Chemical Science Vol. 13 No. 3 (2024): Indonesian Journal of Chemical Science
Publisher : Prodi Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/ijcs.v13i3.8648

Abstract

Hipertensi adalah suatu kondisi medis kronis yang terjadi ketika tekanan darah melebihi batas normal sehingga dapat meningkatkan risiko komplikasi penyakit lainnya seperti penyakit jantung. Pengobatan hipertensi saat ini sebagian besar menggunakan obat golongan Angiotensin Converting Enzyme (ACE) inhibitors. Salah satu bahan alam yang memiliki potensi menurunkan tekanan darah ialah daun jambu biji. Tujuan penelitian ini adalah mengevaluasi senyawa aktif yang terdapat pada daun jambu biji terhadap interaksi secara molekuler pada protein ACE dengan pendekatan studi in silico. Metode yang digunakan dalam pengujian ini meliputi karakteristik drug likeness berdasarkan kaidah Lipinski, prediksi profil ADMET, penapisan farmakofor, dan penambatan molekul. Hasil pengujian menunjukkan senyawa asam klorogenat dan luteolin yang terkandung pada daun jambu biji memiliki interaksi baik dengan protein target ACE berdasarkan energi ikatannya. Oleh karena itu, daun biji dapat dikembangkan lebih lanjut sebagai kandidat berbasis bahan alam untuk membantu dalam terapi hipertensi.
Formulation of Calcium-Protein Capsule Supplements for Stunting Toddlers by Utilizing Leftover Milkfish Bones Production Nurhaliza, Sarah Raisya; Anggi, Joseph Fide; Christella, Angel; Hess, Aurelina Yunita; Nadhira, Mazaya Salwa; Sopyan, Iyan
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 10, No 1 (2025)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v10i1.90769

Abstract

Stunting is a health problem in children due to chronic malnutrition. Stunting is characterized by failure of growth and development in children. If stunting occurs during the Golden Period (age 0-5 years), it can impact the child's brain cells, causing them not to grow optimally. Indonesia has a stunting prevalence of 36% and has not reached the WHO's expected level of below 20%. Milkfish bones (Chanos chanos) are the remaining processed products of the fishing industry that have not been maximally utilized and will generally be disposed of into the environment or reprocessed and used as animal feed. With the presence of calcium and protein in the milkfish's bones, the milkfish's bones can be utilized as capsule supplements to address stunting in toddlers. This research was conducted to determine milkfish bones' calcium and protein content and obtain the most suitable capsule supplement formulation for stunting. This research was carried out through several stages, such as making milkfish bone powder, formulating and making stunting capsule supplements, evaluating the preparation, and analyzing and concluding the research results. The calculation of the consumption capsule supplement dose uses the percentage of calcium and protein content determined by AAS and Kjeldahl, which is then multiplied by the total weight of the capsule. The capsule consumption frequency is determined to fulfill the calcium requirement. The dose analysis and calculation results indicate that toddlers aged 1-3 years can consume two capsules daily, which is equivalent to 264.96 mg calcium and 88.32 mg protein, while toddlers aged 4-8 can consume three capsules daily, which is equivalent to 397.44 mg calcium and 32.48 mg protein. The dosage is determined based on the daily calcium needs of toddlers, which is 700 mg for children aged 1-3 years and 1000 mg for children aged 4-8 years. Therefore, developing milkfish bones with their calcium and protein content into capsule supplements could address toddler stunting.
Co-Authors Andhryanti, Rifa Nurfadila Anggi, Joseph Fide Christella, Angel Dhania Novitasari Fardhan, Firghi Muhammad Iyan Sopyan Muljono, Fajar Oktavian Nadhira, Mazaya Salwa Nurhaliza, Sarah Raisya Ramadhani, Siti Zhahira Zhafirah, Noor